ID E9F4D8_METRA Unreviewed; 576 AA.
AC E9F4D8;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 2.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Choline dehydrogenase {ECO:0000313|EMBL:EFY97495.2};
GN ORFNames=MAA_07137 {ECO:0000313|EMBL:EFY97495.2};
OS Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium
OS anisopliae (strain ARSEF 23)).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=655844 {ECO:0000313|EMBL:EFY97495.2, ECO:0000313|Proteomes:UP000002498};
RN [1] {ECO:0000313|EMBL:EFY97495.2, ECO:0000313|Proteomes:UP000002498}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA Wang C.;
RT "Genome sequencing and comparative transcriptomics of the model
RT entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL PLoS Genet. 7:E1001264-E1001264(2011).
RN [2] {ECO:0000313|EMBL:EFY97495.2, ECO:0000313|Proteomes:UP000002498}
RP GENOME REANNOTATION.
RC STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA St Leger R.J., Wang C.;
RT "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT adaptation.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFY97495.2}.
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DR EMBL; ADNJ02000002; EFY97495.2; -; Genomic_DNA.
DR RefSeq; XP_007823326.2; XM_007825135.2.
DR AlphaFoldDB; E9F4D8; -.
DR GeneID; 19261423; -.
DR KEGG; maj:MAA_07137; -.
DR HOGENOM; CLU_002865_7_2_1; -.
DR OrthoDB; 3382025at2759; -.
DR Proteomes; UP000002498; Unassembled WGS sequence.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.30.560.10; Glucose Oxidase, domain 3; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR PANTHER; PTHR11552:SF219; GMC_OXRDTASE_N DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00624; GMC_OXRED_2; 1.
PE 3: Inferred from homology;
FT DOMAIN 269..283
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00624"
FT ACT_SITE 512
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-1"
FT ACT_SITE 555
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-1"
SQ SEQUENCE 576 AA; 63064 MW; C7741FED45A1A202 CRC64;
MWPFDSQYPC KRLQDIADQA YDYIIVGGGT AGCALASKLS ESPETTVLML EKGPIKDSYQ
SRIPLASVAN GIYTKRQNSS LGSRPVPILS AETLGGNSRI NAMIYTRGTP AYYNQWARTH
PDWSWVNVEP YFRKVENSIN LCQNRELESN IYPFLRKSAS ALGLPLGHDI NRPDSPAMGY
FDLHLTVDSK QHRHSAVRAY LPKEVAVRRR ARLHICTGVV ASRLHLDAST GLVKGVFVQS
SQAKQTDSKT SPRKPTLVKA RREVILAAGA IGTPKILQLS GVGPRLVLER VGIPVVRHLP
GVGSNLGDHC LFPVHVQVPV HETLQQLQAS ILKRAKHAVL YAVAGKGWLR SAVDRAILLC
TSHFDEEKGA VLATEAADDG ETLPDVEIMV VPIGSLPELY PGKSMITLQT CLIQPKSTGT
IEITSPDPGV DARIQLNILS DPSDWQVARK ACRFALALAE HFIHQSGYPS EARVFAGPGS
VGAREWKEGD WRVVSDQEID TYIGMYVGSG FHLTSSCRMG REEDGGVVDS QLRVHGFKNL
RIADASVLPC VPPGHPMAPT YMISERCADF IKDGRN
//
