ID E9FIN3_9STRE Unreviewed; 443 AA.
AC E9FIN3;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=CBS domain protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF0849_01558 {ECO:0000313|EMBL:EFX56154.1};
OS Streptococcus sp. C300.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=563036 {ECO:0000313|EMBL:EFX56154.1, ECO:0000313|Proteomes:UP000003809};
RN [1] {ECO:0000313|EMBL:EFX56154.1, ECO:0000313|Proteomes:UP000003809}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C300 {ECO:0000313|EMBL:EFX56154.1,
RC ECO:0000313|Proteomes:UP000003809};
RG The Broad Institute Genome Sequencing Platform;
RA Ward D., Earl A., Feldgarden M., Gevers D., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A.M., Borenstein D., Chapman S.B., Chen Z., Engels R.,
RA Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E.R.,
RA Heiman D.I., Hepburn T.A., Howarth C., Jen D., Larson L., Mehta T.,
RA Park D., Pearson M., Richards J., Roberts A., Saif S., Shea T.D.,
RA Shenoy N., Sisk P., Stolte C., Sykes S.N., Walk T., White J., Yandava C.,
RA Sibley C.D., Field T.R., Grinwis M., Eshaghurshan C.S., Surette M.G.,
RA Haas B., Nusbaum C., Birren B.;
RT "The Genome Sequence of Streptococcus sp. C300.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the UPF0053 family.
CC {ECO:0000256|ARBA:ARBA00006337}.
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DR EMBL; GL732469; EFX56154.1; -; Genomic_DNA.
DR RefSeq; WP_000390015.1; NZ_GL732469.1.
DR AlphaFoldDB; E9FIN3; -.
DR HOGENOM; CLU_015237_4_0_9; -.
DR Proteomes; UP000003809; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR InterPro; IPR005170; Transptr-assoc_dom.
DR PANTHER; PTHR43099:SF5; INTEGRAL MEMBRANE PROTEIN-RELATED; 1.
DR PANTHER; PTHR43099; UPF0053 PROTEIN YRKA; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF01595; CNNM; 1.
DR Pfam; PF03471; CorC_HlyC; 1.
DR SMART; SM01091; CorC_HlyC; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR PROSITE; PS51371; CBS; 2.
DR PROSITE; PS51846; CNNM; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW ProRule:PRU00703}; Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 64..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 102..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5..203
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT DOMAIN 220..280
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 286..343
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT COILED 299..346
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 443 AA; 49840 MW; 8E0CEC8050466905 CRC64;
MEDPSSQNLL LQFVLLFILT LLNAFFSATE MAMVSLNRSR VEQKAEEGDK RYIRLLKVLE
NPNHFLSTIQ VGITLITILS GASLADTLGR EIASWIGNSE TAYAIASFLS LAFLTYISIV
FGELYPKRIA LNLKDTLAIR TAPVIIGLGK IVSPFVWLLS ASTNLLSRLT PMTFDDADEK
MTRDEIEYML TKSEETLDAD EIEMLQGIFS LDELMAREVM VPRTDAFMVD IQDDSQTIIQ
SILKQNFSRI PVYDGDKDNV IGLIHTKRLL NAAYADGFEN IVWKKILQDP LFVPETIFVD
DLLKELRNTQ RQMAILLDEY GGMAGLVTLE DLLEEIVGEI DDETDRAEIE VHQIGEDTYI
AQGTMNLNDF NNYFGVELES DDVDTIAGYY LTGVGTIPTT EKISYQLVSQ NKQVVLTNDK
VKNGRVTKVK VQITELEPEE ETE
//
