ID E9FL29_9STRE Unreviewed; 752 AA.
AC E9FL29;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Negative regulator of genetic competence ClpC/MecB {ECO:0000313|EMBL:EFX59188.1};
GN Name=clpC {ECO:0000313|EMBL:EFX59188.1};
GN ORFNames=HMPREF0851_00160 {ECO:0000313|EMBL:EFX59188.1};
OS Streptococcus sp. M334.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=563038 {ECO:0000313|EMBL:EFX59188.1, ECO:0000313|Proteomes:UP000003840};
RN [1] {ECO:0000313|EMBL:EFX59188.1, ECO:0000313|Proteomes:UP000003840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M334 {ECO:0000313|EMBL:EFX59188.1,
RC ECO:0000313|Proteomes:UP000003840};
RG The Broad Institute Genome Sequencing Platform;
RA Ward D., Earl A., Feldgarden M., Gevers D., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A.M., Borenstein D., Chapman S.B., Chen Z., Engels R.,
RA Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E.R.,
RA Heiman D.I., Hepburn T.A., Howarth C., Jen D., Larson L., Mehta T.,
RA Park D., Pearson M., Richards J., Roberts A., Saif S., Shea T.D.,
RA Shenoy N., Sisk P., Stolte C., Sykes S.N., Walk T., White J., Yandava C.,
RA Sibley C.D., Field T.R., Grinwis M., Eshaghurshan C.S., Surette M.G.,
RA Haas B., Nusbaum C., Birren B.;
RT "The Genome Sequence of Streptococcus sp. M334.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC {ECO:0000256|RuleBase:RU004432}.
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DR EMBL; GL732486; EFX59188.1; -; Genomic_DNA.
DR RefSeq; WP_000882536.1; NZ_GL732486.1.
DR AlphaFoldDB; E9FL29; -.
DR eggNOG; COG0542; Bacteria.
DR HOGENOM; CLU_005070_4_0_9; -.
DR OrthoDB; 9803641at2; -.
DR Proteomes; UP000003840; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001943; UVR_dom.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF193; CHAPERONE PROTEIN CLPB; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS00871; CLPAB_2; 1.
DR PROSITE; PS50151; UVR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004432}.
FT DOMAIN 365..400
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT REGION 67..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 752 AA; 83763 MW; 3CCB4C55D3D223E9 CRC64;
MLCQNCKIND STIHLYTNLN GKQKQIDLCQ NCYKIIKTDP NNSLFKGMTD LNNRDFDPFG
DFFNDLNNFR PSSNTPPTPP TQSGGGYGGN GGYGSQNRGP AQTPPPSQEK GLLEEFGINV
TEIARRGDID PVIGRDDEII RVIEILNRRT KNNPVLIGEP GVGKTAVVEG LAQKIVDGDV
PHKLQGKQVI RLDVVSLVQG TGIRGQFEER MQKLMEEIRK REDIILFIDE IHEIVGAGSA
GDGNMDAGNI LKPALARGEL QLVGATTLNE YRIIEKDAAL ERRMQPVKVD EPTVEETITI
LKGIQKKYED YHHVQYTDAA IEAAATLSNR YIQDRFLPDK AIDLLDEAGS KMNLTLNFVD
PKVIDQRLIE AENLKSQATR EEDFEKAAYF RDQIAKYKEM QKKKVTDQDT PIISEKTIEH
IIEQKTNIPV GDLKEKEQSQ LIHLAEDLKS HVIGQDDAVD KIAKAIRRNR VGLGTPNRPI
GSFLFVGPTG VGKTELSKQL AIELFGSADS MIRFDMSEYM EKHSVAKLVG APPGYVGYDE
AGQLTEKVRR NPYSLILLDE VEKAHPDVMH MFLQVLDDGR LTDGQGRTVS FKDAIIIMTS
NAGTGKAEAS VGFGAAREGR TNSVLGELGN FFSPEFMNRF DGIIEFKALS KDNLLQIVEL
MLADVNKRLS SNNIHLDVTD KVKEKLVDLG YDPKMGARPL RRTIQDYIED AITDYYLENP
SEKDLKAVMT SKGNIQIKSA KKTEVKTSEK EV
//
