ID E9FLR1_9STRE Unreviewed; 2077 AA.
AC E9FLR1;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Helicase C-terminal domain protein {ECO:0000313|EMBL:EFX59420.1};
GN ORFNames=HMPREF0851_00394 {ECO:0000313|EMBL:EFX59420.1};
OS Streptococcus sp. M334.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=563038 {ECO:0000313|EMBL:EFX59420.1, ECO:0000313|Proteomes:UP000003840};
RN [1] {ECO:0000313|EMBL:EFX59420.1, ECO:0000313|Proteomes:UP000003840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M334 {ECO:0000313|EMBL:EFX59420.1,
RC ECO:0000313|Proteomes:UP000003840};
RG The Broad Institute Genome Sequencing Platform;
RA Ward D., Earl A., Feldgarden M., Gevers D., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A.M., Borenstein D., Chapman S.B., Chen Z., Engels R.,
RA Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E.R.,
RA Heiman D.I., Hepburn T.A., Howarth C., Jen D., Larson L., Mehta T.,
RA Park D., Pearson M., Richards J., Roberts A., Saif S., Shea T.D.,
RA Shenoy N., Sisk P., Stolte C., Sykes S.N., Walk T., White J., Yandava C.,
RA Sibley C.D., Field T.R., Grinwis M., Eshaghurshan C.S., Surette M.G.,
RA Haas B., Nusbaum C., Birren B.;
RT "The Genome Sequence of Streptococcus sp. M334.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL732486; EFX59420.1; -; Genomic_DNA.
DR eggNOG; COG0553; Bacteria.
DR eggNOG; COG0827; Bacteria.
DR eggNOG; COG4646; Bacteria.
DR HOGENOM; CLU_000181_7_0_9; -.
DR OrthoDB; 9815272at2; -.
DR Proteomes; UP000003840; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR41313; ADENINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR41313:SF1; DNA METHYLASE ADENINE-SPECIFIC DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000313|EMBL:EFX59420.1};
KW Helicase {ECO:0000313|EMBL:EFX59420.1};
KW Hydrolase {ECO:0000313|EMBL:EFX59420.1};
KW Nucleotide-binding {ECO:0000313|EMBL:EFX59420.1}.
FT DOMAIN 1645..1829
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 243..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2077 AA; 239528 MW; 3B8F39D49AD91C42 CRC64;
MKGASMEVVQ LLAMFRGTIP KDREKMDLFL RYQAQHFDEK WQDLVESFLA EEGKIEEIPH
VYSFYQDIVS FLEASSENND QDLESYTRTF GQAGLDKLSQ LSNFEKNLVL EVAIYNLSTR
FYIQSEKKKL EPLSELVCHQ NKDVNLVNVY RVANNLSDRI SRDIEEFLLM VDSKELKKEV
LEIHFEEKEG DVLAYLGSEL MATLDTVTDL VHHEENYTQL PLTQKLKIIT HFDEVKAIRE
KSNQVEESLS PSSDIEQETE ETNSFSNVDK IVEEALREYP IGSQVSYKGQ VFQLVSIENA
QLNDLVRLEL FSDSNQLFEE NPILYLNSLE EIEQVLSHVE LEKDDSEIEI DPSSESQEID
LFSYLEEDNE KEKDKETKPL ISGIEETDVT VQDFVFPDDL EDFYPKTNRE KIETNIAAIK
LVKRLEKEGR QANPEEQELL AKYVGWGGLA NEFFDELNPK YESERLTLRS LVSKSEYSTM
KQSSLTAYYT DPMIIRQIWQ KLLDDGFEGG RILDPSMGTG NFFAAMPRSI RERSELYGVE
LDSVTGAIAK QLHPNTHIEV RGFEEVPYQN NSFDLVLTNV PFGNFRIADK NYDKPYMIHD
YFVKHSLDLV RDGGQVSIIS SIGTMDKRTD NVLQEIKTNT HFLGGVRLPD TAFKKIAGTR
VTTDLLFFQK DQAKNLNEEE LVFSGSIPFE EDKRVWINPY FDGKYNTQVL GQYEVRNFNG
GTLNVKRVSE TLATDIMKAF ENVEAPRPID NSLKAPVFIQ EEVDNSIPSR IREDLALYSF
GYEGKQIYYR DTHGIRKSSK VDEISYYVDE KGDFKAWDSS LSEHKIDRFV QLHLTDEEAL
DVYKSEEASK RGKYKGLFKK TVFYESPLSN KDISRIKGMV DLRETYQALI EIQRHQDYSR
TDFQVLLSKL NHDYDRFVSQ FGYLNASVNR NLFDSDDKYS LLASLEDEYI DSKDQKVKYK
KSLAFEKALV RPERVITRVS TALDALNSSL SDGRGVDLDY MVSIYPEHSQ AAILDELGDQ
VLMDPESYLR GEKKYLSKNQ FLSGDILNKI EVVQLLVEEN NQECDWSHAL DLLESVRPPR
IHLADIEFKI GSRWIPQSVY GKFAFECFTN REFELSSPDV EQVIEVNPVD GQVHLRTSFA
YRYPSAKDSS LGVNGSRYDT GRKIFENLLN SNQPTITMTV TEGEKKKTIT DLEKTSVLRA
KEQHLQELFQ DFVSRYPEVQ QVIEESYNRL YNRTVSREYD GSHLVIDGLA QNISFRPHQE
NAIQRIVEEK RALLAHEVGS GKTLTMLGAG FKLKELGMVH KPLYVVPSSL SAQFGQEIMK
FFPTKKVFVT TKKDFVKARR KQFVSRIITG DYDAIVIGDS QFEKIPVSKE RQMNYIEDKL
NELREIKTHS ENKYTVKEAE QSISGLEKQL EELQRFNRDS FIDFENLGID FLFVDEAHHF
KNIRPITGLG NVAGITNTTS KKNVDMEMKV RQIQEEHDFK NIVFATGTPV SNSISELYTM
MNYIQPDILK RYQVDYFDSW VGAFGEIQNS MELAPTGDKY QPKKRFKKFV NLPELMKIYK
ETADIQTQDM LDLPVPEAHL IPIESELTEN QKLYLEELVM RSDAVKCGTV DPSQDNMLKI
TGEARKLAID MRLLDSSYSL ADNHKLLQVV DNVERIYREG MGNKATQMIF SDIGTPKKKD
NGFDVYSEIK ALLVDRGIPS KEIAFVHDAN SDEKKNSLSR KVNAGEVRIL LASTEKGGTG
LNVQSKMKAV HHLDVPWRPS DIQQRNGRII RQGNENKEVD IYHYITKGSF DNYLWATQEN
KLRYIKQIMT SKEPIRAAED IDEQTMTASD FKALATGNPY LKYKMELEND LTLLENQRRA
FQRSKDHYRH TISYCEENMP ILEKRLSKYE GDIQQSEMSK DQAFSMTVGK QAFDQRSEAG
ESLHRLIRHN QADSKEFRTL ASYRGFDIKM LSLPINQPLP ETFSVKIVGE NQYSVSLDLY
SPLGTIQRLQ HTIDHIKEDQ VKTQNLLDEL QDKLTTAKVE IEKNFPKEED YQTKKAEYDV
LSPLIETETD LDIIDQALRQ FHEKGKERQE QLSFELD
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