ID E9FYR1_DAPPU Unreviewed; 1088 AA.
AC E9FYR1;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=RING-type domain-containing protein {ECO:0000259|PROSITE:PS50089};
GN ORFNames=DAPPUDRAFT_312065 {ECO:0000313|EMBL:EFX87578.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX87578.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX87578.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
CC -!- SUBCELLULAR LOCATION: Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004492}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004492}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004492}.
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DR EMBL; GL732527; EFX87578.1; -; Genomic_DNA.
DR AlphaFoldDB; E9FYR1; -.
DR STRING; 6669.E9FYR1; -.
DR EnsemblMetazoa; EFX87578; EFX87578; DAPPUDRAFT_312065.
DR KEGG; dpx:DAPPUDRAFT_312065; -.
DR eggNOG; KOG2114; Eukaryota.
DR HOGENOM; CLU_001287_0_1_1; -.
DR InParanoid; E9FYR1; -.
DR OMA; ENECPAC; -.
DR PhylomeDB; E9FYR1; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0030897; C:HOPS complex; IBA:GO_Central.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR GO; GO:0007032; P:endosome organization; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0048284; P:organelle fusion; IBA:GO_Central.
DR GO; GO:0007033; P:vacuole organization; IBA:GO_Central.
DR GO; GO:0006904; P:vesicle docking involved in exocytosis; IBA:GO_Central.
DR CDD; cd16688; RING-H2_Vps11; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR024763; VPS11_C.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR23323; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR23323:SF24; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG; 1.
DR Pfam; PF00637; Clathrin; 1.
DR Pfam; PF12451; VPS11_C; 1.
DR Pfam; PF13923; zf-C3HC4_2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50236; CHCR; 2.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000305};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 784..823
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 887..919
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 962..984
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1027..1088
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 741..775
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1088 AA; 122815 MW; 7681B9C9C69FED4D CRC64;
MAFFQWRRFN FFELLKETDS GNLERSFKDV TITSSSSGRG HIVLGDNLGL VHLFDRQYQR
ESFKAYNVNT SHVLQLKQSP FLGTVGEDDP GVNPVIKIWN LEKKDIHGCP VCVHLVRALP
GNRPVPVTAF TIDEQMHLMA AGFADGSVVL YRGDLSRERH SKQKFLQPGT SLIAGLSLRT
NQKLSHLYVA TTTAVLTYAI ASKDKEKYAE LDRVGCSLGC VAFADSKQGQ HFMIARNDAV
YCYSVEGRGP CYAFEGEKLD LHWFRGYLVI VSKVVGKGDV DSDKTTVTIF DVNNKFIAFT
APIANAYRVI SEWGSLLVLT KDKKVHQLME KDLHTKLDIL FKKNLYDVAI RVAKSQQYDI
EGLVEIFKLY GDHLYAKGNH SGAMEQYLKT IGRLEPSYVI KKFLDAQRIH QLTAYLQELH
KQGLASEDHT TLLLNCYTKL RDTERLNQFL NTKDQRSEFD VETAIRVCRQ AGYFEQALRL
SQDREKHEWH LKILLEDLSD YRQALEYIKK LPPDLAKENL LEYGNALVEE LPDDTTKLLL
ELCCNKSSTS EVCDPQEFLL LFINHNEKLV EFLENVLQVH PNSQSSLHFA LLEQYLLMWT
KNIADPELEK KITLLLQHSS VLSAADRALF LCQTHKFRPG ILFIFEKTKL YEEILHFYAS
ENNFENVIAT CRRFGQQEPS LWVKALTLST SNDKVTPGCL AEILASIEKL KLLPALRVIE
MLCRSPSATL GLARDYLIRT LQSDQSNISE DERLIQQYRQ ETEAVREKIK DIKTSALVFQ
GSKCNVCNQP LELPSVHFLC LHSFHQHCFD SYADNENECP ACHTENKRIL DIVRAQEQSK
DLHEAFHGQL EKADDPFTVL ADYFGRGVFN SLPSWESAIS GHQGVRSELP SVSWGPQNAG
PGSEAKLRKN EGKNTISSTG FANEGRMRLQ ESASVRPTRD VTEGRLRNAE VIGAAERVAS
SAAATTTSEA RHRLQEGTTK KNYQTASVEI PRQTVASQSA TSVPNYVGPR AICVPAVSDL
STSLRKPEVN KLPPSKTCAN KISVGPENPF KDDNYDETKN PFADEKPTNP FGDDDDDDYN
DSLNPFAE
//
