ID E9FZ87_DAPPU Unreviewed; 910 AA.
AC E9FZ87;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Protein kinase domain-containing protein {ECO:0000259|PROSITE:PS50011};
GN ORFNames=DAPPUDRAFT_312503 {ECO:0000313|EMBL:EFX87308.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX87308.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX87308.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
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DR EMBL; GL732528; EFX87308.1; -; Genomic_DNA.
DR AlphaFoldDB; E9FZ87; -.
DR STRING; 6669.E9FZ87; -.
DR EnsemblMetazoa; EFX87308; EFX87308; DAPPUDRAFT_312503.
DR KEGG; dpx:DAPPUDRAFT_312503; -.
DR eggNOG; KOG0504; Eukaryota.
DR eggNOG; KOG1027; Eukaryota.
DR HOGENOM; CLU_319398_0_0_1; -.
DR InParanoid; E9FZ87; -.
DR OMA; NVNINCK; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:1990604; C:IRE1-TRAF2-ASK1 complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0004521; F:RNA endonuclease activity; IBA:GO_Central.
DR GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IBA:GO_Central.
DR GO; GO:0036498; P:IRE1-mediated unfolded protein response; IBA:GO_Central.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 5.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR045133; IRE1/2-like.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR13954; IRE1-RELATED; 1.
DR PANTHER; PTHR13954:SF6; NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE; 1.
DR Pfam; PF12796; Ank_2; 4.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00248; ANK; 15.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000000305}.
FT DOMAIN 3..275
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 30
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 910 AA; 104404 MW; 1E461DBEEBADCD17 CRC64;
MELDKDEILG SGGYGVVFAG TYDGNPVAIK RIQLTDDLTE LLREEDALKK LNHPNVVKLY
SITSNDDFKF FILERCKASL KDLFEKPEKY KGQIKLPFNH DIMFQLAKGL DYIHSQKIVH
RDIKPANVLV SVDDQSRQVT MKWTDFGLSK TVNERETFSI SGVKGTMDWF APEVFASETN
QDSENKMRGT TKSDVFSEGC VFGYLLLDGQ HPFGSTDAEN EIQSNILKEN FVNLKQMKTR
GTPYAGLIIN RMITKNPGDR ITSGQVVRLL EDVQFKSKIQ DRESVLTRLC KQHNQHPDLA
EMEYFFKEIT DVSFGGPAGE RMEPLVFICQ RYSQENLIDI VRALIERDID ANSKNDDGFN
ALLVLCLNYR HDNLIEIVRV LIDKDVDVNW TADGWNALLF LCRYYPHKNL VDVVQILVDK
GIDVNYCDGD GWNALLFLCR YYQQDNLIEI LQILIRMNVD VNSSDTDGWN ALLFLSQFYP
HDNLVEIVKI LIDSGIDVNL KTNLGWNAMH LLSQFYPHQN LIEIVQIFIA KGVDINLNTS
GGWNACLLLS RNYSQENLID IIKIFIDGNV NINCKKNGWN ALLFLCQHYS NRNLIEIVQF
LVENEINVSC KNEDGWNALL LLCRHYSQDN LIDLIQILID KEINLNYRND GWNALLLLSR
YYPHDNLPAI IQILTERDID VNCRHDNGWN ALPILCQYYK HENLIEIVKT LIDKNINVNA
KNDQGWNALL LLLRDYKHNN LIAIVNLLIS NGIDVHCKNS DGCNALYVLC QNYSHNNSLE
IARVLIEKNV DVNSKHKNGN NALLLLCWGS RLLENVTSII RLLIENNINI HLKDQDGFNA
FLVWCTFCRQ EDLMEILKML AEQNVDITCK NYEGLNGLQI LTKRFSKTVV DMVVNLLTEH
GYNMDSISLL
//
