ID E9G379_DAPPU Unreviewed; 238 AA.
AC E9G379;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Spaetzle domain-containing protein {ECO:0000259|Pfam:PF16077};
GN ORFNames=DAPPUDRAFT_98286 {ECO:0000313|EMBL:EFX85727.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX85727.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX85727.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GL732531; EFX85727.1; -; Genomic_DNA.
DR AlphaFoldDB; E9G379; -.
DR STRING; 6669.E9G379; -.
DR EnsemblMetazoa; EFX85727; EFX85727; DAPPUDRAFT_98286.
DR KEGG; dpx:DAPPUDRAFT_98286; -.
DR eggNOG; ENOG502RZ0W; Eukaryota.
DR HOGENOM; CLU_092569_0_0_1; -.
DR InParanoid; E9G379; -.
DR PhylomeDB; E9G379; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IEA:UniProt.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0005121; F:Toll binding; IBA:GO_Central.
DR GO; GO:0021556; P:central nervous system formation; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR032104; Spaetzle.
DR PANTHER; PTHR23199:SF12; NEUROTROPHIN 1-RELATED; 1.
DR PANTHER; PTHR23199; UNCHARACTERIZED; 1.
DR Pfam; PF16077; Spaetzle; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000305};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..238
FT /note="Spaetzle domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003236609"
FT DOMAIN 138..234
FT /note="Spaetzle"
FT /evidence="ECO:0000259|Pfam:PF16077"
SQ SEQUENCE 238 AA; 26755 MW; 294ECE3F392E4BBD CRC64;
MKIALLCLAS VMMGVFAEPE PEAEAAFDPT NYPKSSYPAD YAKKYTGEND YCHPRKAPTC
SKNGTLTFCV KDPEYPGKEV KYAIDYDPLV LKKYAEITDQ SADNLVDGLT SLSEKHFDYS
EYQGKTFEKG NWVGGEGYIC PSDVVYARPL RAVNVDGEWR VIVQDIAWPG YTQTHRVEKC
LFPGAACRTL APCFGSKCLQ KYVYQRMLSF DPCDPQKGIF IDIYKLPSAC SCHIPRKL
//
