ID E9GNX1_DAPPU Unreviewed; 890 AA.
AC E9GNX1;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EFX78827.1};
GN ORFNames=DAPPUDRAFT_245715 {ECO:0000313|EMBL:EFX78827.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX78827.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX78827.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
CC -!- SIMILARITY: Belongs to the GcvT family.
CC {ECO:0000256|ARBA:ARBA00008609}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GL732555; EFX78827.1; -; Genomic_DNA.
DR AlphaFoldDB; E9GNX1; -.
DR STRING; 6669.E9GNX1; -.
DR EnsemblMetazoa; EFX78827; EFX78827; DAPPUDRAFT_245715.
DR KEGG; dpx:DAPPUDRAFT_245715; -.
DR eggNOG; KOG2844; Eukaryota.
DR HOGENOM; CLU_007884_11_0_1; -.
DR InParanoid; E9GNX1; -.
DR OMA; TKFPDRE; -.
DR PhylomeDB; E9GNX1; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005759; C:mitochondrial matrix; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR Gene3D; 2.40.30.110; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.70.1400; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR006076; FAD-dep_OxRdtase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR032503; FAO_M.
DR InterPro; IPR028896; GCST/YgfZ/DmdA.
DR InterPro; IPR013977; GCV_T_C.
DR InterPro; IPR006222; GCV_T_N.
DR InterPro; IPR029043; GcvT/YgfZ_C.
DR InterPro; IPR027266; TrmE/GcvT_dom1.
DR PANTHER; PTHR43757; AMINOMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR43757:SF9; SARCOSINE DEHYDROGENASE; 1.
DR Pfam; PF01266; DAO; 1.
DR Pfam; PF16350; FAO_M; 1.
DR Pfam; PF01571; GCV_T; 1.
DR Pfam; PF08669; GCV_T_C; 1.
DR SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF103025; Folate-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000305}.
FT DOMAIN 19..386
FT /note="FAD dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF01266"
FT DOMAIN 389..444
FT /note="FAD dependent oxidoreductase central"
FT /evidence="ECO:0000259|Pfam:PF16350"
FT DOMAIN 449..748
FT /note="Aminomethyltransferase folate-binding"
FT /evidence="ECO:0000259|Pfam:PF01571"
FT DOMAIN 775..864
FT /note="Glycine cleavage T-protein C-terminal barrel"
FT /evidence="ECO:0000259|Pfam:PF08669"
SQ SEQUENCE 890 AA; 100160 MW; C37B1B412DC8671F CRC64;
MYERSYSFTT AEALPSHAKV VICGGGVQGA ALGYFLAQHG WGQDTLILDQ GKIGRATPWH
MSGLIGIFKP TSTETRITEE SIKLYDELAR MGYDTGFKQC GSLLLARTRD RMTHFRRMKS
HAVCRKIECY LLTNEEIAKR YPYINTQDLQ GGLWIPIDAV ADPHKICESL ATLAAAKGVR
MFEHIQVNRV LTSQNKVAAI ETDRGTIKCD FFVNCAGFWA RSLGKKTEPL VKVPVQAVEH
YYLHTKPVKD IDENMPVVRD LDGHVYFRVQ NGCVLAGGFE PLAKPVFEDG ALPLSVEDSR
LEVDWDHFAP MLEQMVWQII ELVFNEYPLC ETLFSINSAT DQKASLLIVN GFWARASEVD
NYFVATGMKS LGIASAGGVA KHLSEWIVTG KPPYPLNELN VQRFVPLHNN RQFLLERMRE
VPGVHYQLPY PFSEFRTGRR LRVSPVFPRL KAAGAVFGQT MGYERPAYYE PKPYQDSDIE
DLTSRSTGGT SQNVEAPFRV AYTNTFMKPH WFESVRNEYR ACRESVAIAD YSSFTKLDLT
SPGSEVVDFL QYVCSNDVDV PIGAILHTGM HNENGGYESD CSLARLSDNH YMMIAPIIQQ
TRCQAWLRRQ QQKFAGGNNA SVNISDVTSL YTALCVMGPL SRAVLSELTE ADLSPKSFPF
FTVKEMDMGS ASGIRAMNLT HTGEMGWVLY IPNEAALHVY DKIMEHGRKY AIHHAGYLAT
RSLRVERFYA YWGQDIDAST TPLECGRGFR VKLNSDINFI GREALLKQKK EGVQRMYVQF
QLDDHDPEID PWPWGSEPIY RNGEFAGMVT TAGFGFTLNR QVCLGYVQNY DVTGTVHRLT
PDYVTSGQYE VDIAGLRYNA RVSLRSPTLP TKFRETYGDH YVATRHGGGA
//
