ID E9HBP3_DAPPU Unreviewed; 370 AA.
AC E9HBP3;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Calcineurin-like phosphoesterase domain-containing protein {ECO:0000259|Pfam:PF00149};
GN ORFNames=DAPPUDRAFT_60800 {ECO:0000313|EMBL:EFX70884.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX70884.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX70884.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the metallophosphoesterase superfamily. MPPE1
CC family. {ECO:0000256|ARBA:ARBA00008895}.
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DR EMBL; GL732616; EFX70884.1; -; Genomic_DNA.
DR AlphaFoldDB; E9HBP3; -.
DR STRING; 6669.E9HBP3; -.
DR EnsemblMetazoa; EFX70884; EFX70884; DAPPUDRAFT_60800.
DR KEGG; dpx:DAPPUDRAFT_60800; -.
DR eggNOG; KOG3662; Eukaryota.
DR HOGENOM; CLU_047168_2_0_1; -.
DR InParanoid; E9HBP3; -.
DR OMA; AVPAMTW; -.
DR PhylomeDB; E9HBP3; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:InterPro.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR033308; PGAP5/Cdc1/Ted1.
DR PANTHER; PTHR13315; METALLO PHOSPHOESTERASE RELATED; 1.
DR PANTHER; PTHR13315:SF0; METALLOPHOSPHOESTERASE 1; 1.
DR Pfam; PF00149; Metallophos; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000305};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 71..289
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
SQ SEQUENCE 370 AA; 43095 MW; 96F7DB10285EEC85 CRC64;
MGIFNAESPI VKLSQHVENN IPKQKMNRYI FLITFFICLV FFFCEYLIYF IVQFQCDWPA
LSQNNQSHQL RALILADTHL LGPYRGHWFD KLRREWQMSV SWSAAITLHS PKAVFFLGDI
FDEGKWANQN QYEDYVERFT QLFPSNSPHY VLVGNHDVGF HYMMDAIKLN RFYQTFNLSS
SDIFRVGGIP FVTVNSMAME GDGCHICKEA EKRITSIASG LKANEKPVLL QHFPLFRKSD
ESCQGEDSAP DEEKVVNFRP KFDCLSKTSS NWLLRNLKPR VVFSGHTHHS CVYNHSGVTE
FSVPSFSWRN RNNPSYLLVI ISTDEYAVYK CFMPKESTVI RIYVIFVIVL MISSIFFGYK
RFRARHVKTL
//
