ID E9HMB1_DAPPU Unreviewed; 584 AA.
AC E9HMB1;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=VWFD domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=DAPPUDRAFT_64092 {ECO:0000313|EMBL:EFX67110.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX67110.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX67110.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
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DR EMBL; GL732685; EFX67110.1; -; Genomic_DNA.
DR AlphaFoldDB; E9HMB1; -.
DR STRING; 6669.E9HMB1; -.
DR EnsemblMetazoa; EFX67110; EFX67110; DAPPUDRAFT_64092.
DR KEGG; dpx:DAPPUDRAFT_64092; -.
DR eggNOG; KOG1216; Eukaryota.
DR HOGENOM; CLU_018024_2_0_1; -.
DR InParanoid; E9HMB1; -.
DR OMA; NNETWNL; -.
DR PhylomeDB; E9HMB1; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR GO; GO:0036122; F:BMP binding; IBA:GO_Central.
DR GO; GO:0030513; P:positive regulation of BMP signaling pathway; IBA:GO_Central.
DR Gene3D; 6.20.200.20; -; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 2.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR46698; CROSSVEINLESS 2; 1.
DR PANTHER; PTHR46698:SF4; CROSSVEINLESS 2; 1.
DR Pfam; PF08742; C8; 1.
DR Pfam; PF00093; VWC; 1.
DR Pfam; PF00094; VWD; 1.
DR SMART; SM00832; C8; 1.
DR SMART; SM00214; VWC; 2.
DR SMART; SM00215; VWC_out; 1.
DR SMART; SM00216; VWD; 1.
DR SUPFAM; SSF57603; FnI-like domain; 3.
DR PROSITE; PS50184; VWFC_2; 2.
DR PROSITE; PS51233; VWFD; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000305};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 58..130
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 221..292
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 296..468
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT REGION 20..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 565..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 584 AA; 62501 MW; 3884525E16B43ACB CRC64;
MTCQGGVVTL SRQTCRWNWP ADGRQTASSG SEPTSSSQDG TCHHLLPPRT GECCPRCKTC
KWNGGGGGRN VTADHQGGPV SPDPQKEPCT QCQCLPNGQG MTCTRQTCPV LPCPANKALL
QPGACCPVCQ GVRKEIVPSP PSAISSSNCH IGKKTFELGA KFRPDPCTNC TCQANSTTVC
RQQEASSSSI PAGGAGAGKS IGAAALAAAM APTALPASRP LTCAYRGVTY QDGAGWSLDP
CTQCSCAQGE VRCAVQQCPP TLPTLQGGGS SQPCPPGRHP VKEPGQCCPK CVEDDAVCTV
FGDPHYRTFD GRVFNFQGAC KYLLTSDCRN DTFSVRVTND ARSSRSFSWT KTVTLTIEDL
KVTLGQNMKV KVNHKRVSLP FVSLGVLSVV QEGYSVVVRT NLGVKLLWDG ESFLEVTVPP
AFKRRLCGLC GNFNGRRRDD LRMRSGQLAQ TVEQFGASWK VGGPKSCSSA TSISTPAEEP
LCQRQWHIRI RAVRECSVLK AATFAQCHPQ VSPVRFFKSC LLDMCECPSG KQCYCEALTA
YAHECARHGV TQIDPKWREV TACTGHHHHS SSPSSSTTSA VTQL
//
