ID E9HNY7_DAPPU Unreviewed; 1964 AA.
AC E9HNY7;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Down syndrome cell adhesion molecule-like protein Dscam2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=DAPPUDRAFT_331991 {ECO:0000313|EMBL:EFX66551.1};
OS Daphnia pulex (Water flea).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX66551.1, ECO:0000313|Proteomes:UP000000305};
RN [1] {ECO:0000313|EMBL:EFX66551.1, ECO:0000313|Proteomes:UP000000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21292972; DOI=10.1126/science.1197761;
RA Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT "The ecoresponsive genome of Daphnia pulex.";
RL Science 331:555-561(2011).
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DR EMBL; GL732700; EFX66551.1; -; Genomic_DNA.
DR STRING; 6669.E9HNY7; -.
DR EnsemblMetazoa; EFX66551; EFX66551; DAPPUDRAFT_331991.
DR KEGG; dpx:DAPPUDRAFT_331991; -.
DR eggNOG; KOG3510; Eukaryota.
DR HOGENOM; CLU_001038_4_0_1; -.
DR InParanoid; E9HNY7; -.
DR OMA; SRECKLR; -.
DR PhylomeDB; E9HNY7; -.
DR Proteomes; UP000000305; Unassembled WGS sequence.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0098632; F:cell-cell adhesion mediator activity; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR GO; GO:0070593; P:dendrite self-avoidance; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IBA:GO_Central.
DR CDD; cd00063; FN3; 5.
DR CDD; cd00096; Ig; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 14.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44170:SF48; MYOPALLADIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 5.
DR Pfam; PF07679; I-set; 6.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00409; IG; 9.
DR SMART; SM00408; IGc2; 9.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 8.
DR PROSITE; PS50853; FN3; 5.
DR PROSITE; PS50835; IG_LIKE; 8.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000305};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1855..1879
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 399..490
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 504..580
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 604..689
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 723..808
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 814..904
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 909..999
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1004..1101
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1106..1198
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1203..1307
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1312..1421
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1422..1520
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1508..1612
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1616..1717
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1290..1309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1916..1937
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..54
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1964 AA; 215394 MW; AAF7B6A672AEC7D2 CRC64;
MTGRRGRPPS VTSLTNNKRG TTVHHMSTRK KSVPSSSSKK KRACDTEQQE GNKNNETESE
LQSESSTSTS LPLSVGAVPQ RSTNTQTLDA SCHSRYSSSS SHTSTSSRHS VPQDVLTDGH
VKRLAYPLSF FEYHGPSQKE GNSLYICTVK GCKRGDKPFS TVNNSRGNLR SHVKSCHKKK
LEEFNAACRD LDLKKAMATG LPISTNNSAK DDQNQLEGND ETQQKSFTQQ KIHFSDVHSA
EYRCLASTAT GALLSPPIII RSAVIGALQV YASDAYTLPG NPAVLPCLVM LPVEQAWAVE
VTHWTASSGP NNQHLVDSHS IPQPGSKYVV IGGHLHVSDV TLEDTLMSYR CFARHRLNLA
QKAVNNYSSP PARIVFTHQQ QQQQQLPMAP QLVAFVHRPS TTSLRIRHVR LAQDDVYMTC
TVLAYPPAKI RWFKVNPSNG AAVALVTDGR RITTGGDWFR IGQPAGDDAG RYRCQAANSQ
GQMESEFQLN VHGPLRARLE PQRQPAELTC NVSGLLSPGL TTPSIRWTRN GLDIAVDGGR
FYLPQANVLR VNRAAVTDSG MYQCFVRVDT SGQVQQQSVT AHALAGSYQQ VQASAELIVR
DTAPSRLTDV FNEQMVYPGR PAYLQCSLAS NFSPSPPSIA WTVDSLTIPY TSRRVSISSH
LLDNNGIIRS YLNISSSEVE DGGLYCCSII YPGLGAGQMD HLDTILAASQ EQHCARLNVY
GVPAIRWAGN KTAVAGQDYY LDCPFAGYPV QSISWLRGGQ LIRDTDAKYK PFTNGTLRIS
TMEPGVDNGE YTCLVKGSGS SMAKKALFIE IIRPPVIEPF GFPIQVQDSG RTQVTCSISS
GDLPIKVSWT KDGRPIANNL NVEMQTGEFH SLLIFKKLRG EHSGIYTCTA RNLAKAASHS
ATLLVQVPPK WIIEPQDIAL LENYPASIPC QVHGMPTPIV RWFRIEGENN IPVHSSSKIG
LLADGSLRFS KMAKNDEGLF QCRAGNNIGN AVSKTIRISV NAAAKVRIHT SGAIFPTGSE
AVLRCEASGD PPMTVHWKRF DQLIESHQQM DRFQLSSVAS DGRDFLDLNI SRVEADDGGM
YVCQAANLYG SDATDIRLIV QELPRAPGQL QLTSVQSRSA ELQWLDEDID PLLEYRVQLT
RPGTIGWTFN QTIEARGRSL VTLPHLHPFT VYEVQVNAIN SAGIGPPSAP LQFQTHEEVP
SGPVRHVQAE SKSSRSALVS WLPPSEETWN GRLVTFTVTC LETNGNGQIV QRSVAYTTTD
FRPVRRVQVT VEELRPAIVY AVTVRALNRM GAGPESDPPV SLTTPEAPPS SSPVNLHCVT
LSADAIQLTW AHPTVANHHG HLQGFRIFYK VFSSNNRHRI VLADEVSSFL RPESKRVGPN
VLDSVLYGLQ AYQNYSIQIA ALNRAGSGPL SVPVVCQTDE TVPVAVHEVK AASLSSSSIL
MTWRRSTPPS GRIAHYVIQI KDTVTQDVKR FMHHESDNAL EHQIGQLVEN RPYEISVTAK
GRAGESRPSR TLTISPAAKN GAKILEFSRT IWIEEEHRTD KIILPCPTAG TNPVEKSWTF
AGQPLSSNPH LNYRWDKDGA IQLLDVDRNT EGDYTCTVRN QHGRDAVVFT VHLLRPPEVP
QLSVTPTSTS SIRLWWNKPS SSNSRLGTLL AVLEYIVLYR PAFSGSAVQE KSVDGSEDGT
VLDGLLCGTQ YELQVQARNQ IGLGQKSPLL RAMTRGSGPA NWPELSSLFG FSAAMPATLF
LHLDHWPTGG CRINSFQVEK EGPVLSSPSA DHSHGSWNTL ASNLNPDEQP MLKVSDFIED
ETYHLKLTAS SDSGVHHASY TVRRMSGKKV EYNGTAFEVL PMMASAGQSI SYESLIVIAS
MSISGTMLLF SLAAITYVVH KRKEYQANAA SAVAAAGMSG KSEYSLRTVA EQLDNQPVDD
NNHQYQPQQH GRSLPRANGV NGSIYSLRKQ IDFGTFQFEF PAFN
//
