ID E9NRZ8_PIG Unreviewed; 1368 AA.
AC E9NRZ8;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Bromodomain-containing protein 4 {ECO:0000313|EMBL:ADW77216.1};
DE EC=3.1.1.31 {ECO:0000313|EMBL:ADW77216.1};
GN Name=BRD4 {ECO:0000313|EMBL:ADW77216.1};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|EMBL:ADW77216.1};
RN [1] {ECO:0000313|EMBL:ADW77216.1}
RP NUCLEOTIDE SEQUENCE.
RA Dawson H.D., Chen C.T.;
RT "Global Gene Expression Profiling of Alveolar Macrophages by Deep
RT Sequencing.";
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; HQ700701; ADW77216.1; -; mRNA.
DR RefSeq; NP_001191701.1; NM_001204772.1.
DR SMR; E9NRZ8; -.
DR GeneID; 100533540; -.
DR KEGG; ssc:100533540; -.
DR CTD; 23476; -.
DR OrthoDB; 152619at2759; -.
DR Genevisible; E9NRZ8; SS.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0017057; F:6-phosphogluconolactonase activity; IEA:UniProtKB-EC.
DR CDD; cd05497; Bromo_Brdt_I_like; 1.
DR CDD; cd05498; Bromo_Brdt_II_like; 1.
DR Gene3D; 1.20.1270.220; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 2.
DR InterPro; IPR031354; BRD4_CDT.
DR InterPro; IPR043508; Bromo_Brdt_I.
DR InterPro; IPR043509; Bromo_Brdt_II.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR027353; NET_dom.
DR InterPro; IPR038336; NET_sf.
DR PANTHER; PTHR22880:SF143; BROMODOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR22880; FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS; 1.
DR Pfam; PF17035; BET; 1.
DR Pfam; PF17105; BRD4_CDT; 1.
DR Pfam; PF00439; Bromodomain; 2.
DR PRINTS; PR00503; BROMODOMAIN.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SMART; SM00297; BROMO; 2.
DR SUPFAM; SSF47370; Bromodomain; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 2.
DR PROSITE; PS51525; NET; 1.
PE 2: Evidence at transcript level;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Hydrolase {ECO:0000313|EMBL:ADW77216.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 75..147
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 368..440
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 600..682
FT /note="NET"
FT /evidence="ECO:0000259|PROSITE:PS51525"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 242..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 463..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 673..1108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1123..1345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..224
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..274
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..340
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..517
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..573
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..588
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..614
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 694..708
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..745
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..791
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 834..851
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 852..879
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 889..912
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 931..946
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 952..971
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 979..1044
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1077..1101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1183..1199
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1211..1231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1232..1294
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1295..1310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1331..1345
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1368 AA; 152724 MW; 8010ED689760F246 CRC64;
MSAESGPGTR LRNLPVMGDG LETTQMSTTQ AQAQPQQANT ASTNPPPPET SNPNKPKRQT
NQLQYLLKVV LKTLWKHQFA WPFQQPVDAV KLNLPDYYKI IKTPMDMGTI KKRLENNYYW
NAQECIQDFN TMFTNCYIYN KPGDDIVLMA EALEKLFLQK INELPTEETE IMIVQAKGRG
RGRKEAVSAK PGVSTVPNTT QASTPPQTQT PQQNPPPVQA TPHPFPAVTP DLIVQTPVMT
VVPPQPLQTP PPVPPQPLPP PAPAPQPVQS HPPIIAATPQ PVKTKKGVKR KADTTTPTTI
DPIHEPPSLP PEPKTTKLGP RRESSRPVKP PKKDVPDSQQ HPAPDKSSKV SEQLKCCSGI
LKEMFAKKHA AYAWPFYKPV DVEALGLHDY CDIIKHPMDM STIKSKLEAR EYRDAQEFGA
DVRLMFSNCY KYNPPDHEVV AMARKLQDVF EMRFAKMPDE PEEPVVAVSS PAVPPPTKVV
APPSSSDSSS DSSSDSDSST DDSEEERAQR LAELQEQLKA VHEQLAALSQ PQQNKPKKKE
KDKKEKKKEK HKKKEEVEEN KKSKAKELPP KKTKKNNSSN SNTSKKEPAP LKNKPPPAYE
SEEEDKCRPM SYDEKRQLSL DINKLPGEKL GRVVHIIQSR EPSLKNSNPD EIEIDFETLK
PSTLRELERY VTSCLRKKRK PQAEKVDVIA GSSKMKGFSS SESESTSESS SSDSEDSETE
MAPKSKKKGH PGREQKKHHH HHHQQMQQAP APMPQPPPPP PPQQPPPPPP PPQQPPPQQP
PAPPPPPSMP QQAASAMKSS PPPFIAAQVP VLEPQLPGSV FDPIGHFTQP ILHLPQPELP
PHLPQPPEHS TPPHLNQHSV VSPPALHNAL PQQPSRPSNR AAALPPKTAR PPAVSPALAQ
PPLIPQPPMA QPPQVLLQED EDPPAPPLTS MQMQLYLQQL QKVQPPTPLL PSVKVQSQPP
PPLPPPPHPS VQQLQQQQQQ QPPPPPPQPQ PPPQQQHQPP PRPVHMQPMQ FPTHIQQPPP
PPGQQPPHPP TGQQPPPPQP AKPQQVIQHH PSPRHHKSDP YSTGHLREAP SPLMIHSPQM
PQFQSLTHQS PPQQNVQPKK QELRAASVVQ PQPLVVVKEE KIHSPIIRSE PFSPSLRPEP
PKHPESIKAP VHLPQRPEMK PVDVGRPVIR PPEQNAPPPG APDKDKQKQE PKTPVAPKKD
LKIKNMGSWA SLVQKHPTTP SSTAKSSSDS FEQFRRAARE KEEREKALKA QAEHAEKEKE
RLRQERMRSR EDEDALEQAR RAHEEARRRQ EQQQQQRQEQ QQQQQQAAAV AAAAAPQARS
SQPQSMLDQQ RELARKQEQE RRRREAMAAT IDMNFQSDLL SIFEENLF
//
