ID E9PMJ1_HUMAN Unreviewed; 168 AA.
AC E9PMJ1;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=RAB30, member RAS oncogene family {ECO:0000313|Ensembl:ENSP00000434953.1};
DE Flags: Fragment;
GN Name=RAB30 {ECO:0000313|Ensembl:ENSP00000434953.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000434953.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000434953.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [3] {ECO:0000313|Ensembl:ENSP00000434953.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004423}; Lipid-
CC anchor {ECO:0000256|ARBA:ARBA00004423}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004423}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000256|ARBA:ARBA00006270}.
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DR EMBL; AP000893; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP001767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; E9PMJ1; -.
DR SMR; E9PMJ1; -.
DR MassIVE; E9PMJ1; -.
DR MaxQB; E9PMJ1; -.
DR PeptideAtlas; E9PMJ1; -.
DR ProteomicsDB; 22130; -.
DR Antibodypedia; 31346; 352 antibodies from 26 providers.
DR Ensembl; ENST00000531021.5; ENSP00000434953.1; ENSG00000137502.10.
DR UCSC; uc058fzr.1; human.
DR HGNC; HGNC:9770; RAB30.
DR VEuPathDB; HostDB:ENSG00000137502; -.
DR GeneTree; ENSGT00940000156875; -.
DR HOGENOM; CLU_041217_10_6_1; -.
DR OMA; VYDVSCQ; -.
DR ChiTaRS; RAB30; human.
DR Proteomes; UP000005640; Chromosome 11.
DR Bgee; ENSG00000137502; Expressed in medial globus pallidus and 179 other cell types or tissues.
DR ExpressionAtlas; E9PMJ1; baseline and differential.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0032482; P:Rab protein signal transduction; IEA:InterPro.
DR CDD; cd04114; Rab30; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041820; Rab30.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR47977; RAS-RELATED PROTEIN RAB; 1.
DR PANTHER; PTHR47977:SF64; RAS-RELATED PROTEIN RAB-30; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00176; RAN; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
DR PROSITE; PS51420; RHO; 1.
PE 1: Evidence at protein level;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0007829|EPD:E9PMJ1,
KW ECO:0007829|MaxQB:E9PMJ1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT NON_TER 168
FT /evidence="ECO:0000313|Ensembl:ENSP00000434953.1"
SQ SEQUENCE 168 AA; 19250 MW; FCFDA6DB1D004E61 CRC64;
MSMEDYDFLF KIVLIGNAGV GKTCLVRRFT QGLFPPGQGA TIGVDFMIKT VEINGEKVKL
QIWDTAGQER FRSITQSYYR SANALILTYD ITCEESFRCL PEWLREIEQY ASNKVITVLV
GNKIDLAERR EVSQQRAEEF SEAQDMYYLE TSAKESDNVE KLFLDLAC
//
