ID E9PVL3_MOUSE Unreviewed; 393 AA.
AC E9PVL3;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Interferon activated gene 214 {ECO:0000313|Ensembl:ENSMUSP00000087888.6};
DE SubName: Full=p214 {ECO:0000313|EMBL:AEK98514.1};
GN Name=Ifi214 {ECO:0000313|EMBL:AEK98514.1,
GN ECO:0000313|Ensembl:ENSMUSP00000087888.6,
GN ECO:0000313|MGI:MGI:3584522};
GN Synonyms=BC094916 {ECO:0000313|MGI:MGI:3584522};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000087888.6, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000087888.6, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000087888.6,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|EMBL:AEK98514.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AEK98514.1};
RC TISSUE=Spleen {ECO:0000313|EMBL:AEK98514.1};
RA Stacey K.J., Cridland J.A.;
RT "The IFI200 gene family.";
RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000087888.6}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000087888.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the HIN-200 family.
CC {ECO:0000256|ARBA:ARBA00008647}.
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DR EMBL; JN200820; AEK98514.1; -; mRNA.
DR ProteomicsDB; 337109; -.
DR Ensembl; ENSMUST00000090406.6; ENSMUSP00000087888.6; ENSMUSG00000070501.15.
DR AGR; MGI:3584522; -.
DR MGI; MGI:3584522; Ifi214.
DR VEuPathDB; HostDB:ENSMUSG00000070501; -.
DR GeneTree; ENSGT00390000013296; -.
DR HOGENOM; CLU_020123_2_0_1; -.
DR Proteomes; UP000000589; Chromosome 1.
DR Bgee; ENSMUSG00000070501; Expressed in spleen and 12 other cell types or tissues.
DR GO; GO:0002218; P:activation of innate immune response; IEA:InterPro.
DR GO; GO:0035458; P:cellular response to interferon-beta; IEA:InterPro.
DR CDD; cd08305; Pyrin; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 2.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR040205; HIN-200.
DR InterPro; IPR004021; HIN200/IF120x.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR PANTHER; PTHR12200:SF24; INTERFERON-ACTIVABLE PROTEIN 203-RELATED; 1.
DR PANTHER; PTHR12200; INTERFERON-INDUCIBLE PROTEIN AIM2 FAMILY MEMBER; 1.
DR Pfam; PF02760; HIN; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF159141; HIN-2000 domain-like; 2.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50834; HIN_200; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 1..87
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 219..393
FT /note="HIN-200"
FT /evidence="ECO:0000259|PROSITE:PS50834"
FT REGION 82..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..99
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 393 AA; 43809 MW; 563C417BF9378BE3 CRC64;
MVNEYKRIVL LTGLMGINDH DFRMVKSLLS KELKLNKMQD EYDRVKIADL MEDKFPKDAG
VVQLIKLYKQ IPGLGDIANK LKNEKAKAKR KGKGKRKTAA KRQRQEEPST SQPMSTTNED
AEPESGRSTP DTQVAQLSLP TASRRNQAIQ ISPTIASSSG QTSSRSSETL QSIIQSPETP
TRSSSRILDP PVSPGTAYSS AQALGVLLAT PAKRQRLKNV PKEPSEENGY QQGSKKVMVL
KVTEPFAYDM KGEKMFHATV ATETEFFRVK VFDIVLKEKF IPNKVLTISN YVGCNGFINI
YSASSVSEVN DGEPMNIPLS LRKSANRTPK INYLCSKRRG IFVNGVFTVC KKEERGYYIC
YEIGDDTGMM EVEVYGRLTN IACNPGDKLR LML
//
