ID E9PWJ0_MOUSE Unreviewed; 3538 AA.
AC E9PWJ0;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=CUB and Sushi multiple domains 3 {ECO:0000313|Ensembl:ENSMUSP00000124753.2};
GN Name=Csmd3 {ECO:0000313|Ensembl:ENSMUSP00000124753.2,
GN ECO:0000313|MGI:MGI:2386403};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000124753.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000124753.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000124753.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000124753.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000124753.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR SMR; E9PWJ0; -.
DR PeptideAtlas; E9PWJ0; -.
DR ProteomicsDB; 312598; -.
DR Antibodypedia; 26636; 120 antibodies from 22 providers.
DR Ensembl; ENSMUST00000160658.8; ENSMUSP00000124753.2; ENSMUSG00000022311.16.
DR AGR; MGI:2386403; -.
DR MGI; MGI:2386403; Csmd3.
DR VEuPathDB; HostDB:ENSMUSG00000022311; -.
DR GeneTree; ENSGT00940000155549; -.
DR HOGENOM; CLU_000277_0_0_1; -.
DR ChiTaRS; Csmd3; mouse.
DR Proteomes; UP000000589; Chromosome 15.
DR Bgee; ENSMUSG00000022311; Expressed in lumbar subsegment of spinal cord and 106 other cell types or tissues.
DR ExpressionAtlas; E9PWJ0; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 27.
DR CDD; cd00041; CUB; 14.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 27.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 14.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR45656:SF4; PROTEIN BETA CHAIN, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR45656; PROTEIN CBR-CLEC-78; 1.
DR Pfam; PF00431; CUB; 14.
DR Pfam; PF00084; Sushi; 27.
DR SMART; SM00032; CCP; 27.
DR SMART; SM00042; CUB; 14.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 27.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 14.
DR PROSITE; PS01180; CUB; 14.
DR PROSITE; PS50923; SUSHI; 27.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|MaxQB:E9PWJ0,
KW ECO:0007829|ProteomicsDB:E9PWJ0};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 44..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3462..3483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 65..173
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 176..237
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 241..345
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 380..441
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 444..555
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 558..615
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 617..725
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 728..789
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 791..899
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 904..961
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 963..1073
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1076..1135
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1137..1245
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1248..1308
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1310..1419
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1422..1482
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1484..1592
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1595..1656
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1658..1766
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1772..1833
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1835..1943
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1946..2005
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2007..2115
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2118..2177
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2179..2290
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2289..2350
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2352..2463
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2463..2525
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2526..2587
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2588..2645
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2646..2703
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2704..2761
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2762..2823
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2824..2881
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2885..2942
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2943..3001
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3002..3061
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3062..3119
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3120..3177
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3181..3239
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3240..3299
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2883..2902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 586..613
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 932..959
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1310..1337
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 2616..2643
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2674..2701
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2732..2759
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2794..2821
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2852..2879
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2913..2940
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2972..2999
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3090..3117
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3148..3175
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3210..3237
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 3538 AA; 387182 MW; C2523C55308DD2A0 CRC64;
MKGSRKGESR AKESKPREPG TRRCAKCGRL DFILKKKMGI KSGFTFWNLV FLLTLSCVKG
FIYTCGGTLK GLNGTIESPG FPYGYPNGAN CTWVIIAEER NRIQIVFQSF ALEEEYDYLS
LYDGHPHPTN FRTRLTGFHL PPPVTSTKSV FSLRLTSDFA VSAHGFKVYY EELQSSSCGN
PGVPPKGVLY GTRFDVGDKI RYSCVTGYIL DGHPQLTCIA NSVNTASWDF PVPICRAEDA
CGGTMRGSSG IISSPGFPNE YHNNADCTWT IVAEPGDTIS LIFTDFQMEE KYDYLEIEGS
EPPTIWLSGM NIPPPIISNK NWLRLHFVTD SNHRYRGFSA PYQVKKAIDF KSRGFKLFPG
KDNSNKFSLL NEGGIKTASN LCPDPGEPEN GKRFGSDFSL GSTVQFSCDE DYVLQGAKSI
TCQRIAEVFA AWSDHRPVCK VKTCGSNLQG PSGTFTSPNF PFQYDSNAQC VWVITAVNTN
KVIQINFEEF DLEIGYDTLT IGDGGEVGDP RTVLQVLTGS FVPDLIVSMR SQMWLHLQTD
ESVGSVGFKV NYKEIEKESC GDPGTPLYGI REGDGFSNRD VLRFECQFGF ELIGEKSIVC
QENNQWSANI PICIFPCLSN FTAPMGTVLS PDYPEGYGNN LNCIWTIISD PGSRIHLSFN
DFDLESQFDF LAVKDGDSPD SPILGTFTGA EVPSHLTSNS HILRLEFQAD HSMSGRGFNI
TYNTFGHNEC PDPGIPINAR RFGDNFQLGS SISVICEEGF IKTQGTETIT CILMDGKVMW
SGPIPRCGAP CGGHFSAPSG VILSPGWPGY YKDSLNCEWV IEAEPGHSIK ITFERFQTEL
NYDVLEVHDG PNLLSPLLGS YNGTQVPQFL FSSSNFIYLL FTTDNSRSNN GFKIHYESVT
VNTYSCLDPG IPVHGRRYGH DFSIGSTVSF SCDPGYRLSH EEPLLCEKNH WWSHPLPTCD
ALCGGDVRGP SGTILSPGYP EFYPNSLNCT WTVDVTHGKG VQFNFHTFHL EDHHDYLLIT
ENGSFTQPLA RLTGSELPST INAGLYGNFR AQLRFISDFS ISYEGFNITF SEYNLEPCED
PGIPQYGSRV GFSFGVGDTL TFSCSLGYRL EGSSEIICLG GGRRVWSAPL PRCVAECGAS
ATNNEGILLS PNYPLNYENN HECIYSLQVQ AGKGINISAR TFHLAQGDVL KIYDGKDKTT
HLLGAFTGAS MRGLTLSSTS NQLWLEFNSD SEGTDEGFQL VYTSFELSHC EDPGIPQFGY
KISDQGHFAG STIIYGCNPG YTLHGSSLLK CMTGERRAWD YPLPSCIAEC GGRFKGESSG
RILSPGYPFP YDNNLRCMWM IEVDPGNIVS LQFLAFDTEA SHDILRVWDG PPENEMLLKE
VSGSLIPDGI HSTLNIVTIQ FDTDFYISKS GFAIQFSSSV ATACRDPGVP MNGTRNGDGR
EPGDTVVFQC DPGYELQGQE RITCIQVENR YFWQPSPPVC IAPCGGNLTG SSGFILSPNF
PHPYPHSRDC DWTISVNTDY VISLAFISFS IEPNYDFLYI YDGPDSNSPL IGSFQDSKLP
ERIESSSNTM HLAFRSDGSV SYTGFHLEYK AKLRESCFDP GNIMNGTRLG MDYKLGSTVT
YYCDAGYVLQ GYSTLTCIMG DDGRPGWNRV LPSCHAPCGS RSTGSEGTVL SPNYPKNYSV
DHNCVYSIAV PKEFVVFGQF VFFQTSLHDV VEVFDGPTQQ SPLLSSLSGS HSGESLPLSS
GNQITIRFTS VGPITAKGFH FVYQAVPRTS STQCSSVPEP RFGRRIGNDF AVGSLVLFEC
NPGYILHGSR AIRCETVPNS LAQWNDSLPT CIVPCGGILT KRKGTILSPG YPEPYDNNLN
CVWKITVPEG AGIQVQVVSF ATEHNWDSLD FYDGGDNNAP RLGSYSGTTI PHLLNSTSNN
LYLNFQSDIS VSAAGFHLEY TAIGLDSCPE PQTPSSGIKV GDRYMVGDVV SFQCDQGYSL
QGHSHITCMP GPVRRWNYPI PICLAQCGGA MSDFSGVILS PGFPGNYPSS LDCTWTIKLP
IGFGVHLQFV NFSTETIHDY LEVRSGSSEI STVIGRLSGP QIPSSLFSTT HETSLYFHSD
YSQNKQGFHI VYQAYQLQSC PDPRPFRNGF VIGNDFTVGQ TISFECFPGY TLIGNSALTC
LHGVSRNWNH PLPRCEALCG GNITAMNGTI YSPGYPDEYP NFQDCFWLVR VPPGNGIYIN
FTVLQTEPIY DFITVWDGPD QNSPQIGQFS GNTALESVYS TSNQILIKFH SDFTTSGFFV
LSYHAYQLRV CQPPPPVPNA EILTEDDEFE IGDIIRYQCL PGFTLVGNAI LTCRLGERLQ
MDGAPPVCQV LCPANELRLD STGVILSPGY PDSYPNLQMC AWSISVEKGY NISMFVEFFQ
TEKEFDVLQV YDGPNIQSPV LISLSGDYSA AFNVTSNGHE VFLQWSADHG NNKKGFRIRY
IAFYCSTPES PPHGYIISQT GGQLNSVVRW ACDRGFRLVG KSSAVCRKSS YGYHSWDAPV
PACQAISCGI PKAPTNGGIL TTDYLVGTRV TYFCNDGYRL SSKELTTATC QSDGTWSNHN
KTPRCVVISC GELPTPPNGN KIGTQTSYGS TAIFTCDLGF MLVGSAVREC LSSGLWSGSE
TRCLAGHCGI PELIVNGQVI GENYGYRDTV VYQCNPGFRL IGSSVRICQQ DHNWSGQLPS
CVPVSCGHPG SPIYGRTSGN GFNFNDVVTF SCNIGYLMQG PTKAQCQANR QWSHPPPVCK
VVNCSDPGIP ANSKRESKIE HGNFTYGTVV FYDCNPGYFL FGSSVLICQP NGQWDKPLPE
CIMIDCGHPG IPPNAVLSGE KYTFGSTVHY SCTGKRSLLG QASRTCQLNG HWSGSQPHCS
GDTTGTCGDP GTPGHGSRQE SDFRTKSTVR FACDTGYILY GSEERTCLSN GSWTGRQPEC
KAVQCGNPGT TANGKVFRID GTTFSSSVIY SCLEGYILSG PSVRQCTANG TWSGSLPNCT
IISCGDPGIP ANGLRYGDDF VVGQNVSYMC QPGYTIELNG SRVRTCTTNG TWSGVMPTCR
AVTCSTPPQI SNGRLEGTNF DWGFSISYIC SAGYELSFPA VLTCVGNGTW SGEVPQCLPK
FCGDPGIPSQ GKREGKSFIY QSEVSFSCNS PFILVGSSTR LCQTDGTWSG SSPHCIEPTR
TSCENPGVPR HGSQNNTFGF QVGSVVQFHC KKGHLLQGST TRTCLPDLTW SGIQPECIPH
SCKQPESPAH ANVVGMDLPS HGYTLIYTCQ PGFFLAGGTE HRVCRSDNTW TGKVPVCEAG
SKILVKDPRP ALGTPSPKLS VPDDVFAQNY IWKGSYNFKG RKQPMTLTVT SFNASTGRVN
ATLSNSDMEL LLSGVYKSQE ARLMLHIYLI KVPAHASVKK MKEENWAMDG FVSAEPDGAT
YVFQGFIKGK DYGQFGLQRL GLNTSEGSNS SNQPHGTNSS SVAIAILVPF FALIFAGFGF
YLYKQRTAPK TQYTGCSVHE NNNGQAAFEN PMYDTNAKSV EGKAVRFDPN LNTVCTMV
//
