ID E9PXZ3_MOUSE Unreviewed; 1166 AA.
AC E9PXZ3;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Integrin, alpha 10 {ECO:0000313|Ensembl:ENSMUSP00000112393.2};
GN Name=Itga10 {ECO:0000313|Ensembl:ENSMUSP00000112393.2,
GN ECO:0000313|MGI:MGI:2153482};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000112393.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000112393.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000112393.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000112393.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000112393.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR RefSeq; NP_001289400.1; NM_001302471.1.
DR AlphaFoldDB; E9PXZ3; -.
DR SMR; E9PXZ3; -.
DR STRING; 10090.ENSMUSP00000112393; -.
DR PeptideAtlas; E9PXZ3; -.
DR ProteomicsDB; 346662; -.
DR DNASU; 213119; -.
DR Ensembl; ENSMUST00000119365.8; ENSMUSP00000112393.2; ENSMUSG00000090210.8.
DR GeneID; 213119; -.
DR KEGG; mmu:213119; -.
DR UCSC; uc012ctz.1; mouse.
DR AGR; MGI:2153482; -.
DR CTD; 8515; -.
DR MGI; MGI:2153482; Itga10.
DR VEuPathDB; HostDB:ENSMUSG00000090210; -.
DR GeneTree; ENSGT00940000158423; -.
DR HOGENOM; CLU_004111_2_0_1; -.
DR OMA; SRNITRY; -.
DR OrthoDB; 3816176at2759; -.
DR BioGRID-ORCS; 213119; 5 hits in 61 CRISPR screens.
DR ChiTaRS; Itga10; mouse.
DR Proteomes; UP000000589; Chromosome 3.
DR Bgee; ENSMUSG00000090210; Expressed in humerus cartilage element and 132 other cell types or tissues.
DR ExpressionAtlas; E9PXZ3; baseline and differential.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0034680; C:integrin alpha10-beta1 complex; ISO:MGI.
DR GO; GO:0008305; C:integrin complex; IBA:GO_Central.
DR GO; GO:0098639; F:collagen binding involved in cell-matrix adhesion; ISO:MGI.
DR GO; GO:0005178; F:integrin binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0033627; P:cell adhesion mediated by integrin; IBA:GO_Central.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0007160; P:cell-matrix adhesion; ISO:MGI.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; ISO:MGI.
DR CDD; cd01469; vWA_integrins_alpha_subunit; 1.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 2.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF26; INTEGRIN ALPHA-10; 1.
DR Pfam; PF01839; FG-GAP; 1.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 5.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 1: Evidence at protein level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Proteomics identification {ECO:0007829|ProteomicsDB:E9PXZ3};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 23..1166
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5001424267"
FT TRANSMEM 1120..1144
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 24..85
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 167..350
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 472..534
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 535..593
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 597..657
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1166 AA; 127764 MW; F921BF67850BFD72 CRC64;
MESLSIPHLL LPLALLTGLC SSFNLDEHHP RLFTGPPEAE FGYSVLQHVG GGQRWMLVGA
PWDGPSGDRR GDVYRCSIGG FHSAPCTKGH LGDYQLGNSS QPAVNMHLGM SLLETDADGG
FMACAPLWSR ACGSSVFSSG ICARVDASFR PQGSLAPTAQ RCPTYMDVVI VLDGSNSIYP
WSEVQTFLRR LVGRLFIDPE QIQVGLVQYG ENPVHEWSLG DFRTKEEVVR AARNLSRREG
RETRTAQAIM VACTEGFSQS RGGRPEAARL LVVVTDGESH DGEELPAALK ACEAGRVTRY
GIAVLGHYLR RQRDPSSFLR EIRAIASDPD ERFFFNVTDE AALTDIVDAL GDRIFGLEGS
RGENESSFGL EMSEIGFSIH RLQDGILFGM VGAYDWGGSV LWLEEGRRLF PPQAALEDEF
PPALQNHAAY LGYSVSSMLL PGGRRLFLSG APRFRHRGKV IAFQLKKDGV VRVAQSLQGD
QIGSYFGSEL CPLDTDKDGI TNILLVAAPM FLGPQNKETG RVYVYMVGQQ NLLMLQGTLQ
PDRSQDSRFG FAMAALPDLN HDGFTDVAVG APLEDGHRGA LYLYHGTQTG IRPHPTQRIA
AVSMPQALRY FGRSVDGRLD LDGDDLVDVA VGAHGAAVLF SSQPIIHLIP TLDVMPPHIS
VVQKDCKRRG QEAACLTAAL CFQVVSQTPG RWDRRFYIRF SASLDEWTAG ARAVFDGSGQ
RLSPRQLQLS VGNVTCEQLH FHALDTSDYL RPVALTVTFA LDNTTKPGPV LAEGSSTTIR
KLIPFSKDCG PDNECVTDLV LQADMDIRGS RKSPFVVQGG RQKVLVSATL ENKKENAYNT
SLSLSFSRNL HLASLTPQAK SVKVECAVPS PHTRLCTVGH PVFQTGAKVS FLLEFEFSCT
FLLSQVFVRL TASSSSLEMN ETLQDNTAQT SAYIRYEPHL VFSSESTLHR YEVHPYRTLP
MGPGPEFKTT LRVQNLGCHV VSGLVISALL PAVAHGGNYF LSLSQVISGN ASCTVQNLTE
PPGFPVHPEE LQHASRLNGS NSRCQVVRCH LGLLAKGTEI SVRLLRLVHN EFFRRAKFKS
VTVVSTFKLG TEEGSVLLLN EASRSSESHL EVIQTHPTLI SLWILVGSVL GGLLLLALLV
FCLWKLGFFT RKKIPKEEES EEKLEQ
//
