ID E9Q4T9_MOUSE Unreviewed; 335 AA.
AC E9Q4T9;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Transmembrane protease, serine 4 {ECO:0000313|Ensembl:ENSMUSP00000131890.2};
GN Name=Tmprss4 {ECO:0000313|Ensembl:ENSMUSP00000131890.2,
GN ECO:0000313|MGI:MGI:2384877};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000131890.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000131890.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000131890.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000131890.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000131890.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
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DR AlphaFoldDB; E9Q4T9; -.
DR SMR; E9Q4T9; -.
DR MaxQB; E9Q4T9; -.
DR PeptideAtlas; E9Q4T9; -.
DR ProteomicsDB; 371359; -.
DR Antibodypedia; 1732; 352 antibodies from 32 providers.
DR Ensembl; ENSMUST00000165263.9; ENSMUSP00000131890.2; ENSMUSG00000032091.16.
DR AGR; MGI:2384877; -.
DR MGI; MGI:2384877; Tmprss4.
DR VEuPathDB; HostDB:ENSMUSG00000032091; -.
DR GeneTree; ENSGT01020000230389; -.
DR OMA; GNWASAC; -.
DR ChiTaRS; Tmprss4; mouse.
DR Proteomes; UP000000589; Chromosome 9.
DR Bgee; ENSMUSG00000032091; Expressed in right colon and 92 other cell types or tissues.
DR ExpressionAtlas; E9Q4T9; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00112; LDLa; 1.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 3.10.250.10; SRCR-like domain; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR PANTHER; PTHR24252:SF8; ACROSIN; 1.
DR PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR Pfam; PF15494; SRCR_2; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00202; SR; 1.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF56487; SRCR-like; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50287; SRCR_2; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Proteomics identification {ECO:0007829|MaxQB:E9Q4T9,
KW ECO:0007829|PeptideAtlas:E9Q4T9};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 30..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 102..142
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 203..335
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
SQ SEQUENCE 335 AA; 36747 MW; BCB065764A56776C CRC64;
MESDSGQPLN NRDIVPFRKP RRPQETFKKV GIPIIAVLLS LIALVIVALL IKVILDKYYF
ICGSPLTFIQ RGQLCDGHLD CASGEDEEHC VKDFPEKPGV AVRLSKDRST LQVLDAATGT
WASVCFDNFT EALAKTACRQ MGYDSQPAFR AVEIRPDQNL PVAQVTGNSQ ELQVQNGSRS
CLSGSLVSLR CLDCGKSLKT PRVVGGVEAP VDSWPWQVSI QYNKQHVCGG SILDPHWILT
AAHCFRKYLD VSSWKVRAGS NILGNSPSLP VAKIFIAEPN PLYPKEKDIA LVKLQMPLTF
SGSVRPICLP FSDEVLVPAT PVWVIGWGFT EENGG
//
