ID E9Q6H0_MOUSE Unreviewed; 809 AA.
AC E9Q6H0;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN Name=Gucy1b2 {ECO:0000313|Ensembl:ENSMUSP00000128114.2,
GN ECO:0000313|MGI:MGI:2660873};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000128114.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000128114.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000128114.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000128114.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000128114.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; NP_001191269.1; NM_001204340.1.
DR AlphaFoldDB; E9Q6H0; -.
DR SMR; E9Q6H0; -.
DR ProteomicsDB; 322136; -.
DR DNASU; 239134; -.
DR Ensembl; ENSMUST00000165651.8; ENSMUSP00000128114.2; ENSMUSG00000021933.12.
DR GeneID; 239134; -.
DR KEGG; mmu:239134; -.
DR UCSC; uc011znh.2; mouse.
DR AGR; MGI:2660873; -.
DR CTD; 2974; -.
DR MGI; MGI:2660873; Gucy1b2.
DR VEuPathDB; HostDB:ENSMUSG00000021933; -.
DR GeneTree; ENSGT00940000162114; -.
DR HOGENOM; CLU_011614_4_0_1; -.
DR OrthoDB; 2898719at2759; -.
DR BioGRID-ORCS; 239134; 2 hits in 76 CRISPR screens.
DR ChiTaRS; Gucy1b2; mouse.
DR Proteomes; UP000000589; Chromosome 14.
DR Bgee; ENSMUSG00000021933; Expressed in ventricular zone and 13 other cell types or tissues.
DR ExpressionAtlas; E9Q6H0; baseline and differential.
DR GO; GO:0008074; C:guanylate cyclase complex, soluble; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004383; F:guanylate cyclase activity; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0043167; F:ion binding; ISO:MGI.
DR GO; GO:0019934; P:cGMP-mediated signaling; IBA:GO_Central.
DR GO; GO:0070482; P:response to oxygen levels; IBA:GO_Central.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.90.1520.10; H-NOX domain; 1.
DR Gene3D; 3.30.450.260; Haem NO binding associated domain; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR038158; H-NOX_domain_sf.
DR InterPro; IPR011644; Heme_NO-bd.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR042463; HNOB_dom_associated_sf.
DR InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR PANTHER; PTHR45655:SF17; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07700; HNOB; 1.
DR Pfam; PF07701; HNOBA; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF111126; Ligand-binding domain in the NO signalling and Golgi transport; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 534..662
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 756..795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 468..502
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 778..795
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 809 AA; 90461 MW; 68702CF3A1989947 CRC64;
MVMSEVLCAE YTLKVKMSDT ADGVLYEPLR AEFRSKRTHL QGSAEGRGQF LASLQSTSTA
FQRFGKTPGV QLRPGDTTLD TMYGFINTCL QSLVTEKFGE ETWEKLKASA EVQDVFMTYT
VYDDTITVKL IQEACKALDV SMEAILKLFG EYFFKFCKMS GYDRMLRTLG GNLTEFIENL
DALHSYLALS YQEMNAPSFR VEGGADGAMR LHYYSDRRGL CHIVPGIIEA VAKDFFDTDV
AMSILDMNEE VERTGKKEHV VFLVVQKARR QIRGAKSLQG TLLRKKERYL SIPVCPGEKS
HSAVVRASVL LGKGPLGDTF QPVFPERLWI EEEVFCNAFP FHVVFDEALR VKQAGVNIQK
YVPGILTQKF GLDEYFSIVH PQVTFNISSI CKFINSQFIL KTRREMMPEA WKSQPTLKLR
GQMIWMESLK CMVFMCSPKL RSLQELEESK MHLSDIAPHD TTRDLILLNQ QRLAEMELSC
QLEKKKEELR VLSNHLAIEK KKTETLLYAM LPEHVANQLK EGKKVAAGEF ETCTILFSDV
VTFTNICAAC EPIQIVNMLN SMYSKFDRLT NIHDVYKVET IGDAYMVVGG VPVPVESHAQ
RVANFALGMR ISAKEVMNPV TGEPIQIRVG IHTGPVLAGV VGDKMPRYCL FGDTVNTASR
MESHGLPNKV HLSPTAHRAL ENKGFEIVTR GEIEVKGKGK MTTYFLIRNL NATEVEIMGR
PSALADGKEA STPRNQVKKP RAVLSNMDHH QQQVYNSDPA DASDEVTLAG SPVAGRDDTD
AVNSQSSPDE TKTSAFASDP VLSAFCAVL
//