ID E9QQ21_MOUSE Unreviewed; 358 AA.
AC E9QQ21;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=Complement component 5a receptor 2 {ECO:0000313|Ensembl:ENSMUSP00000096389.4};
GN Name=C5ar2 {ECO:0000313|Ensembl:ENSMUSP00000096389.4,
GN ECO:0000313|MGI:MGI:2442013};
GN Synonyms=Gpr77 {ECO:0000313|MGI:MGI:2442013};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000096389.4, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0007829|PubMed:17242355}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000096389.4, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000096389.4,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000096389.4}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000096389.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the chemokine-like receptor (CMKLR) family.
CC {ECO:0000256|ARBA:ARBA00025736}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; NP_001139477.1; NM_001146005.1.
DR AlphaFoldDB; E9QQ21; -.
DR SMR; E9QQ21; -.
DR MaxQB; E9QQ21; -.
DR Antibodypedia; 2937; 456 antibodies from 37 providers.
DR DNASU; 319430; -.
DR Ensembl; ENSMUST00000098792.10; ENSMUSP00000096389.4; ENSMUSG00000074361.12.
DR GeneID; 319430; -.
DR KEGG; mmu:319430; -.
DR UCSC; uc012fae.1; mouse.
DR AGR; MGI:2442013; -.
DR CTD; 27202; -.
DR MGI; MGI:2442013; C5ar2.
DR VEuPathDB; HostDB:ENSMUSG00000074361; -.
DR GeneTree; ENSGT01100000263564; -.
DR HOGENOM; CLU_009579_8_0_1; -.
DR OMA; HRWPLGM; -.
DR OrthoDB; 4264357at2759; -.
DR PhylomeDB; E9QQ21; -.
DR BioGRID-ORCS; 319430; 1 hit in 76 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 7.
DR Bgee; ENSMUSG00000074361; Expressed in granulocyte and 26 other cell types or tissues.
DR ExpressionAtlas; E9QQ21; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004875; F:complement receptor activity; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0006935; P:chemotaxis; IEA:InterPro.
DR CDD; cd15114; 7tmA_C5aR; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR002234; Anphylx_rcpt_C3a/C5a1-2.
DR InterPro; IPR000826; Formyl_rcpt-rel.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24225:SF1; C5A ANAPHYLATOXIN CHEMOTACTIC RECEPTOR 2; 1.
DR PANTHER; PTHR24225; CHEMOTACTIC RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00426; C5ANPHYLTXNR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transducer {ECO:0000256|ARBA:ARBA00023040};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 54..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 93..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 135..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 225..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 255..276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 72..311
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 358 AA; 39857 MW; 9F80650B30438334 CRC64;
MRGREQRSRC LGARMMNHTT SEYYDYEYDH EHYSDLPDVP VDCPAGTCFT SDVYLIVLLV
LYAAVFLVGV PGNTLVAWVT WKESRHRLGA SWFLHLTMAD LLCCVSLPFL AVPIAQKGHW
PYGAAGCWLL SSITILSMYA SVLLLTGLSG DLFLLAFRPS WKGADHRTFG VRVVQASSWM
LGLLLTVPSA VYRRLLQEHY PPRLVCGIDY GGSVSAEVAI TTVRFLFGFL GPLVFMAGCH
GILQRQMARR HWPLGTAVVV GFFICWTPYH VLRVIIAAAP PHSLLLARVL EAEPLFNGLA
LAHSALNPIM FLYFGRKQLC KSLQAACHWA LRDPQDEESA VTKVSISTSH EMVSEMPV
//
