ID EAF_DROSE Reviewed; 503 AA.
AC B4HQT6;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Ell-associated factor Eaf {ECO:0000250|UniProtKB:Q7JRJ1};
GN Name=Eaf {ECO:0000250|UniProtKB:Q7JRJ1}; ORFNames=GM20800;
OS Drosophila sechellia (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7238;
RN [1] {ECO:0000312|EMBL:EDW46746.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rob3c / Tucson 14021-0248.25 {ECO:0000312|EMBL:EDW46746.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Promotes transcriptional elongation by Su(Tpl)/ELL. Essential
CC for development (By similarity). {ECO:0000250|UniProtKB:Q7JRJ1}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96JC9}.
CC -!- SIMILARITY: Belongs to the EAF family. {ECO:0000255}.
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DR EMBL; CH480816; EDW46746.1; -; Genomic_DNA.
DR RefSeq; XP_002032733.1; XM_002032697.1.
DR AlphaFoldDB; B4HQT6; -.
DR SMR; B4HQT6; -.
DR STRING; 7238.B4HQT6; -.
DR EnsemblMetazoa; FBtr0203785; FBpp0202277; FBgn0175681.
DR GeneID; 6607985; -.
DR KEGG; dse:6607985; -.
DR HOGENOM; CLU_025755_2_1_1; -.
DR OMA; SSHMGKQ; -.
DR OrthoDB; 318263at2759; -.
DR PhylomeDB; B4HQT6; -.
DR Proteomes; UP000001292; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR GO; GO:0032783; C:super elongation complex; IEA:EnsemblMetazoa.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; ISS:UniProtKB.
DR InterPro; IPR027093; EAF_fam.
DR InterPro; IPR019194; Tscrpt_elong_fac_Eaf_N.
DR PANTHER; PTHR15970; ELL-ASSOCIATED FACTOR EAF; 1.
DR PANTHER; PTHR15970:SF2; ELL-ASSOCIATED FACTOR EAF; 1.
DR Pfam; PF09816; EAF; 1.
PE 3: Inferred from homology;
KW Activator; Developmental protein; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..503
FT /note="Ell-associated factor Eaf"
FT /id="PRO_0000386604"
FT REGION 119..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 372..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 196
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7JRJ1"
SQ SEQUENCE 503 AA; 54937 MW; A7EEDFE830B0109F CRC64;
MMMTKQKNSL AERLNIGEEA RELKLGATFN PKNTSTAFHT IKYDFKPASV DTSRMASVDV
GSNNQVTVTV PNSESSGVPH TVYKGNQREY AKECLMIYDK ETGAITIEKL NHNIQVKKTR
NEVSNKSVQL PGQNMGQGQP HNQGANGAGP APTSVPGQGS GTAPKMENST MRISTKTKVS
TGSRRNNIID FKPRNSPMQQ NSPSRPVPVH RSPQSAPAWD ANNAQQTLPS IPLITDDDDF
GLRAALHNSG HANRSGSAAG QPDFVSTSSS THIGKQRQAP PHGHGKRQQM HQRLSPPMAQ
QQQQHPSNYG RGYNGGHNHA QQQQQQQRNS PPRQRPSAYG HDNTMDVDSS REHELTSQSV
AQAAAALEQQ IGGVLSASSS SSESDSSDSD SGSDSDDSTE DDRSTQGQQQ DHQQQPHQVY
QNHNHTQQQV TQQHHNQLPN LGLGSISPAY GSNHQQQHQQ QMLQHQQKQK QQSGIYASNG
GFPNDFLQND LQLSSNSSDD DDD
//
