ID EDAR_ORYLA Reviewed; 514 AA.
AC Q90VY2; Q90Z36;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 24-JAN-2024, entry version 124.
DE RecName: Full=Tumor necrosis factor receptor superfamily member EDAR;
DE AltName: Full=Ectodysplasin-A receptor;
DE AltName: Full=Protein reduced scale-3;
DE Short=RS-3;
DE Flags: Precursor;
GN Name=edar; Synonyms=rs3;
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=AA2, and HNI;
RX PubMed=11516953; DOI=10.1016/s0960-9822(01)00324-4;
RA Kondo S., Kuwahara Y., Kondo M., Naruse K., Mitani H., Wakamatsu Y.,
RA Ozato K., Asakawa S., Shimizu N., Shima A.;
RT "The medaka rs-3 locus required for scale development encodes
RT ectodysplasin-A receptor.";
RL Curr. Biol. 11:1202-1206(2001).
CC -!- FUNCTION: Receptor for EDA (By similarity). May mediate the activation
CC of NF-kappa-B and JNK. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Barely detectable on the body surface of 8 and 15
CC day old fish. In 30 day old fish, when scale development has started,
CC expression is high in patches of epithelial cell clusters and at the
CC posterior margins of growing scales.
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DR EMBL; AF364814; AAK83297.1; -; mRNA.
DR EMBL; AF364815; AAK83298.1; -; mRNA.
DR EMBL; AF364816; AAK83299.1; -; mRNA.
DR RefSeq; NP_001098229.1; NM_001104759.1.
DR RefSeq; XP_011487841.1; XM_011489539.1.
DR AlphaFoldDB; Q90VY2; -.
DR SMR; Q90VY2; -.
DR STRING; 8090.ENSORLP00000033496; -.
DR GlyCosmos; Q90VY2; 2 sites, No reported glycans.
DR Ensembl; ENSORLT00000032421.1; ENSORLP00000033496.1; ENSORLG00000015897.2.
DR GeneID; 100049352; -.
DR KEGG; ola:100049352; -.
DR CTD; 10913; -.
DR eggNOG; ENOG502QRV5; Eukaryota.
DR GeneTree; ENSGT00940000153259; -.
DR HOGENOM; CLU_039634_0_0_1; -.
DR InParanoid; Q90VY2; -.
DR OMA; CGENEYH; -.
DR OrthoDB; 5405444at2759; -.
DR TreeFam; TF331385; -.
DR Proteomes; UP000001038; Chromosome 21.
DR Proteomes; UP000265180; Unplaced.
DR Proteomes; UP000265200; Unplaced.
DR Bgee; ENSORLG00000015897; Expressed in pharyngeal gill and 3 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0061972; P:dermal bone morphogenesis; IEA:Ensembl.
DR GO; GO:0007631; P:feeding behavior; IEA:Ensembl.
DR GO; GO:0033333; P:fin development; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IBA:GO_Central.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IBA:GO_Central.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR047526; TNR19/27/EDAR.
DR PANTHER; PTHR12120; TNFR-CYS DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12120:SF9; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER EDAR; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Developmental protein; Differentiation; Disulfide bond;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Repeat; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..514
FT /note="Tumor necrosis factor receptor superfamily member
FT EDAR"
FT /id="PRO_0000034610"
FT TOPO_DOM 28..183
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 205..514
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 31..72
FT /note="TNFR-Cys 1"
FT REPEAT 74..114
FT /note="TNFR-Cys 2"
FT REPEAT 116..149
FT /note="TNFR-Cys 3"
FT DOMAIN 403..476
FT /note="Death"
FT REGION 254..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..292
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 39
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 58
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 32..45
FT /evidence="ECO:0000250"
FT DISULFID 48..61
FT /evidence="ECO:0000250"
FT DISULFID 51..72
FT /evidence="ECO:0000250"
FT DISULFID 75..88
FT /evidence="ECO:0000250"
FT DISULFID 94..114
FT /evidence="ECO:0000250"
FT DISULFID 117..136
FT /evidence="ECO:0000250"
FT DISULFID 139..149
FT /evidence="ECO:0000250"
FT VARIANT 13
FT /note="M -> V (in strain: HNI)"
FT VARIANT 155
FT /note="A -> P (in strain: HNI)"
FT VARIANT 353
FT /note="S -> T (in strain: HNI)"
SQ SEQUENCE 514 AA; 56066 MW; 82C7F0661EECFB48 CRC64;
MKMWKRRGQK KSMFLSSLLV CCMFASAEYS SCGEYEFFNQ TSNSCQACPQ CRPGQEPNMS
CGHGMKDEGF ACVPCPQGKY SKGKYEICRR HKDCNALYKA TVREPGTAEK DAECGPCLPG
YYMLENRARN LYAMVCHSCQ NAPLNTKECK KTTEAIIKPP INPGSTTVLP HPGSPGQGHL
ATALIIAMST IFIMAIAIVL IIMFYILKAK PNGQACCSGQ VVKAVEAQTN KLEDKKDVPD
NVVIFPEKEE YDKLKASPQK TVKSENDASS ENEQLLSRSI DSDEEPTSDK LRSSEATNHN
LCQANVGYKP DLCLLSLGLL DHRVVCNGTP ASAGSQANNT QAPNHITSSN VSSMNAINNN
NKTPGMLQSR RKKILDLYAR TCHVTEGLSP TELPFDCLEK ASRMLSSSYS SDAAVVKTWR
HLAESFGLKR DEIGGMSDGL QLFERVSTAG YSIPDLLARL VQIERLDAVE SLCADVLGSN
EIVALVGRQS VNSFHSQLVC PSPCTSPSPR CASV
//
