ID   ERFD_KLULA              Reviewed;         258 AA.
AC   Q6CXK4;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   24-JAN-2024, entry version 81.
DE   RecName: Full=Ras modification protein ERF4;
GN   Name=ERF4; OrderedLocusNames=KLLA0A07535g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: The ERF2-ERF4 complex is a palmitoyltransferase specific for
CC       Ras proteins. Palmitoylates RAS2, which is required for its proper
CC       plasma membrane localization (By similarity).
CC       {ECO:0000250|UniProtKB:P41912}.
CC   -!- SUBUNIT: Interacts with ERF2. {ECO:0000250|UniProtKB:P41912}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:P41912}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:P41912}.
CC   -!- SIMILARITY: Belongs to the ERF4 family. {ECO:0000305}.
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DR   EMBL; CR382121; CAH02923.1; -; Genomic_DNA.
DR   RefSeq; XP_451335.1; XM_451335.1.
DR   AlphaFoldDB; Q6CXK4; -.
DR   STRING; 284590.Q6CXK4; -.
DR   PaxDb; 284590-Q6CXK4; -.
DR   GeneID; 2896443; -.
DR   KEGG; kla:KLLA0_A07535g; -.
DR   eggNOG; ENOG502S30T; Eukaryota.
DR   HOGENOM; CLU_087349_0_0_1; -.
DR   InParanoid; Q6CXK4; -.
DR   OMA; CITHFPN; -.
DR   Proteomes; UP000000598; Chromosome A.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019383; Golgin_A_7/ERF4.
DR   PANTHER; PTHR13254:SF0; ERF4 DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR13254; GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7; 1.
DR   Pfam; PF10256; Erf4; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome.
FT   CHAIN           1..258
FT                   /note="Ras modification protein ERF4"
FT                   /id="PRO_0000213985"
SQ   SEQUENCE   258 AA;  29308 MW;  AE582AD6EE9E431F CRC64;
     MVSLVLADTA DSSDLSKAAI TVEESTSAQQ PKFFNYHEFV ITKYRALDEE SCEEHGPENP
     ICITHFPNIY VPEESDEFRT TRVVRIPRRF ESSTEFPNFS TQLPGSEPAA LPDTHNKEFV
     PAGEFEGQWY GETSVSPLSN YLDQAEWTEI VTRINSLLEA AYNPITRRNF VNVILDLLTL
     NLWSIIEPYL FVNPLQSVED YVSEINRSES FRLKGIKIIP PRESSYLSVC IDSPAWIKPC
     TAINEPLLTH CDTLIVLL
//