ID F0FDR2_STRSA Unreviewed; 806 AA.
AC F0FDR2;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE SubName: Full=Pilin isopeptide linkage domain protein {ECO:0000313|EMBL:EGC22747.1};
GN ORFNames=HMPREF9388_0844 {ECO:0000313|EMBL:EGC22747.1};
OS Streptococcus sanguinis SK353.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=888815 {ECO:0000313|EMBL:EGC22747.1, ECO:0000313|Proteomes:UP000004185};
RN [1] {ECO:0000313|EMBL:EGC22747.1, ECO:0000313|Proteomes:UP000004185}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK353 {ECO:0000313|EMBL:EGC22747.1,
RC ECO:0000313|Proteomes:UP000004185};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC {ECO:0000256|ARBA:ARBA00004168}; Peptidoglycan-anchor
CC {ECO:0000256|ARBA:ARBA00004168}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGC22747.1}.
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DR EMBL; AEWY01000004; EGC22747.1; -; Genomic_DNA.
DR RefSeq; WP_002897703.1; NZ_GL872307.1.
DR AlphaFoldDB; F0FDR2; -.
DR PATRIC; fig|888815.3.peg.825; -.
DR HOGENOM; CLU_349805_0_0_9; -.
DR Proteomes; UP000004185; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005518; F:collagen binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR Gene3D; 2.60.40.1280; -; 1.
DR Gene3D; 2.60.40.3050; -; 2.
DR Gene3D; 2.60.40.740; -; 1.
DR InterPro; IPR008966; Adhesion_dom_sf.
DR InterPro; IPR008456; Collagen-bd_dom.
DR InterPro; IPR011252; Fibrogen-bd_dom1.
DR InterPro; IPR019931; LPXTG_anchor.
DR InterPro; IPR041171; SDR_Ig.
DR InterPro; IPR041030; SHIRT.
DR InterPro; IPR022464; Strep_pil_isopept_link.
DR InterPro; IPR038174; Strep_pil_link_sf.
DR NCBIfam; TIGR01167; LPXTG_anchor; 1.
DR NCBIfam; TIGR03786; strep_pil_rpt; 2.
DR Pfam; PF17961; Big_8; 1.
DR Pfam; PF05737; Collagen_bind; 1.
DR Pfam; PF12892; FctA; 2.
DR Pfam; PF00746; Gram_pos_anchor; 1.
DR Pfam; PF18655; SHIRT; 2.
DR SUPFAM; SSF49401; Bacterial adhesins; 2.
DR PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
PE 4: Predicted;
KW Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Peptidoglycan-anchor {ECO:0000256|ARBA:ARBA00023088};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..806
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003250610"
FT TRANSMEM 782..800
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 774..806
FT /note="Gram-positive cocci surface proteins LPxTG"
FT /evidence="ECO:0000259|PROSITE:PS50847"
FT REGION 718..775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..755
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 806 AA; 88219 MW; FB3D466DE36E9EEE CRC64;
MKQTYHKVSH ALMTLLLLVS TFLPLLSSSP RVSAAELGES DYQLTTDVTI NTNPLKDTGY
GEGKFYVAPT YTFADSKVLN NGDTMVYRVP SQFKIERTLE ENISAPDGTV VAKLVTDPVT
NTATITVTNA EYFAKMPDTK RIQSSFTVVW ADNMPYDQEQ EVNFPGARTY RLKRIKVDEE
PQGYSKWGVQ DSKDPNYVNW RIRVNRDVQN LGQVVIEDAI PEGQELDEDS GITGYYFTEW
EGASGTRQSF NPSQIVTITD SNHFTVNAGD LSGRGIYVIY RTRLTEPVDK VTKKAFNDVT
VTANGQKMPD LVSRPFAPLT TLDGVGEGTR SDEVIFKVKK ELTGRNLADG EFTFDLINKD
DNDKVVQTVT NKDGAVTFKK LRFKNEGTFN YIIRERASNL PGVTNDANSD INVNVTVTDN
NGVKTAAVTY DREAFTNTYK LEPATAAITA KKVLDGKALE AGKYTFKLTE VGGNNVELQA
TNDANGNIKF SEINYDKEGT YTYKLTEVAG SEAGVTYDST EHTVTVTVTE NNAKLEAAVT
DNNPTFINSY KDYGVSYEFL SSNPAYPNLP KEVTDLLPAD TNRYTSGTNV DAKQPAKTSV
TVTEGTWTFE GYAETNAQTV ADKDLKFTGK WNFTPAPKYK VTYKFVSEDP NRALPAEVTE
LLPTDANEYT DGTAVQAVQP AKDSIEVTGG TWKFLKYDAD SKTIAGSDVK FTGTWTFEAR
RPQGPTPPPS SSDSTPPPSS SGDKPSGSTD GTPGNSSDKD GKDVRGSATG KKVLPKTGSE
TSIFAIAAGF ALILLSALVY RFKKAN
//
