ID F0H2T2_9FIRM Unreviewed; 729 AA.
AC F0H2T2;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Radical SAM domain protein {ECO:0000313|EMBL:EGC83256.1};
GN ORFNames=HMPREF9246_0381 {ECO:0000313|EMBL:EGC83256.1};
OS Anaerococcus hydrogenalis ACS-025-V-Sch4.
OC Bacteria; Bacillota; Tissierellia; Tissierellales; Peptoniphilaceae;
OC Anaerococcus.
OX NCBI_TaxID=879306 {ECO:0000313|EMBL:EGC83256.1, ECO:0000313|Proteomes:UP000005277};
RN [1] {ECO:0000313|EMBL:EGC83256.1, ECO:0000313|Proteomes:UP000005277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ACS-025-V-Sch4 {ECO:0000313|EMBL:EGC83256.1,
RC ECO:0000313|Proteomes:UP000005277};
RA Durkin A.S., Madupu R., Torralba M., Gillis M., Methe B., Sutton G.,
RA Nelson K.E.;
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SIMILARITY: Belongs to the radical SAM superfamily. Anaerobic
CC sulfatase-maturating enzyme family. {ECO:0000256|ARBA:ARBA00023601}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGC83256.1}.
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DR EMBL; AEXN01000039; EGC83256.1; -; Genomic_DNA.
DR RefSeq; WP_004818424.1; NZ_AEXN01000039.1.
DR AlphaFoldDB; F0H2T2; -.
DR OrthoDB; 1737006at2; -.
DR Proteomes; UP000005277; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR023885; 4Fe4S-binding_SPASM_dom.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR026401; CXXX_matur.
DR InterPro; IPR000385; MoaA_NifB_PqqE_Fe-S-bd_CS.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR026412; rSAM_Cxxx_rpt.
DR InterPro; IPR023867; Sulphatase_maturase_rSAM.
DR NCBIfam; TIGR04119; CXXX_matur; 1.
DR NCBIfam; TIGR04115; rSAM_Cxxx_rpt; 1.
DR NCBIfam; TIGR04085; rSAM_more_4Fe4S; 1.
DR PANTHER; PTHR43273; ANAEROBIC SULFATASE-MATURATING ENZYME HOMOLOG ASLB-RELATED; 1.
DR PANTHER; PTHR43273:SF8; RADICAL SAM PROTEIN-RELATED; 1.
DR Pfam; PF13353; Fer4_12; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01383; cyclic_pyranopterin_phosphate; 1.
DR SFLD; SFLDG01384; thioether_bond_formation_requi; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS01305; MOAA_NIFB_PQQE; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 28..179
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|Pfam:PF04055"
SQ SEQUENCE 729 AA; 85262 MW; E27F6AEA302CE028 CRC64;
MIKNNITYKL GKEINIWKDG LAQTLTFIVT EDCNLRCNYC YITHKSSNKK MSFEVAKKFI
DYVLTEEMIR PKGVILDFIG GEPLLEIKLI DQICDYFKLK TYLLNDEWFW DYRINITTNG
INYASKEVQD FIKKNQGKLE IAITLDGTKE KHDMHRIFPN GKGSYDEIIR NIELYKNQFQ
ASTKVTFSSK DLKYLKDSII HLWELGISDV AANVVFEDVW QDGDEKTFED QLIELADYIL
ENRLFDKYSC TLFDESIGSP NSREMLETAS CGAGKMIAVG PDGSLYPCMR YKDYSLNNKK
EIAIGDVENG IDFDKIRPYY LINTQLQSDE ECLNCRIASG CTSCFGHNYD SADSNTNFQK
AKYICKMHKA RVRANNYYFA ELYNRYGIER EINNEERDKL YFLLSNSAVR TCTSSEDRSD
LSIMSDETIK QGLEYAKNNF LRPVFIHSNY GLNLNFKEID LKGHNIFHYC SIRNQDSIRK
ITNNYILTIE YPNDEEFVKN MKLEENIILN ISSDYLSDIE NFVTKLFNKT NRINLNILDI
DKQFNYTLYE NQLKNISDYI YYEYLNKGII KELNVITDEM FMEEKELCDS GLNSYTLASN
EKFYVCPEFY FNFPLDYIGS LKDGIKEKYN RHLYSEKYSP LCNKCSICHC NSCSFENYIN
TNEVNIPAKN SCVKSSIEYR VSYELQKKLS KLMEFDIHIK PLNYLDPFVD VLEKNPVNGI
LNKKYLEDN
//
