ID   F0HW46_LACDL            Unreviewed;       436 AA.
AC   F0HW46;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   SubName: Full=NCS2 family nucleobase:cation symporter-2, purine transporter {ECO:0000313|EMBL:EGD27196.1};
GN   Name=yieG {ECO:0000313|EMBL:EGD27196.1};
GN   ORFNames=HMPREF5505_1143 {ECO:0000313|EMBL:EGD27196.1};
OS   Lactobacillus delbrueckii subsp. lactis DSM 20072.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=888027 {ECO:0000313|EMBL:EGD27196.1, ECO:0000313|Proteomes:UP000004230};
RN   [1] {ECO:0000313|EMBL:EGD27196.1, ECO:0000313|Proteomes:UP000004230}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 20072 {ECO:0000313|EMBL:EGD27196.1,
RC   ECO:0000313|Proteomes:UP000004230};
RA   Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA   Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA   Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA   Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA   Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA   Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA   Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA   Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA   Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA   Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA   Petrosino J., Highlander S., Gibbs R.;
RL   Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|PIRNR:PIRNR005353};
CC       Multi-pass membrane protein {ECO:0000256|PIRNR:PIRNR005353}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC       2.A.40) family. Azg-like subfamily. {ECO:0000256|ARBA:ARBA00005697,
CC       ECO:0000256|PIRNR:PIRNR005353}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EGD27196.1}.
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DR   EMBL; AEXU01000099; EGD27196.1; -; Genomic_DNA.
DR   RefSeq; WP_003616417.1; NZ_GL872382.1.
DR   PATRIC; fig|888027.3.peg.1034; -.
DR   HOGENOM; CLU_024508_0_1_9; -.
DR   Proteomes; UP000004230; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:1904823; P:purine nucleobase transmembrane transport; IEA:UniProt.
DR   InterPro; IPR045018; Azg-like.
DR   InterPro; IPR026033; Azg-like_bact_archaea.
DR   InterPro; IPR006043; NCS2.
DR   PANTHER; PTHR43337:SF11; GUANINE_HYPOXANTHINE PERMEASE PBUG; 1.
DR   PANTHER; PTHR43337; XANTHINE/URACIL PERMEASE C887.17-RELATED; 1.
DR   Pfam; PF00860; Xan_ur_permease; 1.
DR   PIRSF; PIRSF005353; PbuG; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|PIRNR:PIRNR005353};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR005353};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|PIRNR:PIRNR005353};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|PIRNR:PIRNR005353};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005353}.
SQ   SEQUENCE   436 AA;  46195 MW;  D093D8D3BB96EA1F CRC64;
     MEFINKYFEL DKLGSNPKRE FIAGLTTFFA MCYILFVNPS VLGASGMDKG AVFTATALAS
     ALGCLIMGIF ANYPIATAPS LGLNAFFAYT VSIGMKVKWQ TALAAVFLAS IIFILITVFK
     LRELIVDSIP NDLKFAISAG IGIFIAFLGL QNGKLVVNSA STLVTIGSFK DPAAWVTIFG
     LLVTIFLMIR QVPGAIFIGI VLSSIFSILV GQSKMPTSVV SLAPSLKPSF GQAIFHLGDI
     NTVQMWTVVL TFLLVAFFDT TGTLIGLANQ AGLIDKDGKM PRIGKAMAAD STAMMAGSII
     GTSPVGTYVE SSSGIAAGGR SGLTAVWVGI FFLLSMFFSP LLSVVTTTVT APALIIVGVL
     MAANLAKISW DKLEIAVPAF LIVIGMGLTY SIADGMALGL IVYPISMTAA KRTKEVSPMM
     WILAVVFVIY FLILNV
//