ID F0I036_STRSA Unreviewed; 756 AA.
AC F0I036;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=ATP-dependent Clp protease {ECO:0000313|EMBL:EGD30254.1};
GN Name=clpE {ECO:0000313|EMBL:EGD30254.1};
GN ORFNames=HMPREF9381_0526 {ECO:0000313|EMBL:EGD30254.1};
OS Streptococcus sanguinis SK72.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=888809 {ECO:0000313|EMBL:EGD30254.1, ECO:0000313|Proteomes:UP000003332};
RN [1] {ECO:0000313|EMBL:EGD30254.1, ECO:0000313|Proteomes:UP000003332}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK72 {ECO:0000313|EMBL:EGD30254.1,
RC ECO:0000313|Proteomes:UP000003332};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC {ECO:0000256|RuleBase:RU004432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGD30254.1}.
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DR EMBL; AEXV01000005; EGD30254.1; -; Genomic_DNA.
DR RefSeq; WP_002904058.1; NZ_GL872376.1.
DR AlphaFoldDB; F0I036; -.
DR PATRIC; fig|888809.3.peg.514; -.
DR HOGENOM; CLU_005070_4_0_9; -.
DR Proteomes; UP000003332; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001943; UVR_dom.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF193; CHAPERONE PROTEIN CLPB; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS00871; CLPAB_2; 1.
DR PROSITE; PS50151; UVR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW Hydrolase {ECO:0000313|EMBL:EGD30254.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004432}; Protease {ECO:0000313|EMBL:EGD30254.1}.
FT DOMAIN 365..400
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT REGION 59..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 756 AA; 83712 MW; 7873054FE94F8538 CRC64;
MLCQNCKINE STIHLYTNVN GHKQQVDLCQ NCYQIMKTDP EHSLFGGIAN ANNHGTDPID
DFFNSLSNFQ QPQEPTTPPT QSGGAYGGGG GYGSNPSKGG QPQPSPQKPK GLLEEFGINV
TELARRGEID PVIGRDEEIV RVIEILNRRT KNNPVLIGEP GVGKTAVVEG LAQKIVDGDV
PHKLQGKEVI RLDVVSLVQG TGIRGQFEER MQKLIDEIRS RQDVILFIDE IHEIVGAGSA
GDGNMDAGNI LKPALARGEL QMVGATTLNE YRIIEKDAAL ERRMQPVKVD EPTVEETITI
LKGIQKKYED YHHVKYTDAA IEAAALLSNR YIQDRFLPDK AIDLLDEAGS KMNLTLNFVD
PKVIDQRLIE AENLKAQATR DEDFEKAAYF RDQIAKYKEL QQTSVLDKDT PIISEKTIEH
IVEQKTNIPV GDLKEKEQSQ LVNLASDLKT HVIGQDDAVD KIAKAIRRNR VGLGSPNRPI
GSFLFVGPTG VGKTELSKQL AIELFGSADS MIRFDMSEYM EKHSVAKLVG APPGYVGYDE
AGQLTERVRR NPYSLILLDE VEKAHPDVMH MFLQVLDDGR LTDGQGRTVS FKDTIIIMTS
NAGTGKAEAS VGFGAAREGR TNSVLGELGN FFSPEFMNRF DGIIEFQALS KDNLLQIVNL
MLDDVNQRLA TNDIHLDVTE KVKEKLVDLG YDPKMGARPL RRTIQDHIED AITDFYLENP
SEKDLKAIMT SNGKILIKSA KKTESTESVH SSQEEK
//
