ID F0I8Y4_STRSA Unreviewed; 688 AA.
AC F0I8Y4;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Penicillin-binding protein 2B {ECO:0000313|EMBL:EGD32169.1};
DE EC=2.3.2.- {ECO:0000313|EMBL:EGD32169.1};
GN Name=pbpB {ECO:0000313|EMBL:EGD32169.1};
GN ORFNames=HMPREF9382_1123 {ECO:0000313|EMBL:EGD32169.1};
OS Streptococcus sanguinis SK115.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=888810 {ECO:0000313|EMBL:EGD32169.1, ECO:0000313|Proteomes:UP000003351};
RN [1] {ECO:0000313|EMBL:EGD32169.1, ECO:0000313|Proteomes:UP000003351}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK115 {ECO:0000313|EMBL:EGD32169.1,
RC ECO:0000313|Proteomes:UP000003351};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGD32169.1}.
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DR EMBL; AEXW01000005; EGD32169.1; -; Genomic_DNA.
DR RefSeq; WP_002907023.1; NZ_GL872408.1.
DR AlphaFoldDB; F0I8Y4; -.
DR PATRIC; fig|888810.3.peg.1101; -.
DR HOGENOM; CLU_009289_7_0_9; -.
DR Proteomes; UP000003351; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0071972; F:peptidoglycan L,D-transpeptidase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR Gene3D; 1.10.10.1230; Penicillin-binding protein, N-terminal non-catalytic domain, head sub-domain; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR047982; PBP2B.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; NF038278; strep_PBP2B; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:EGD32169.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transferase {ECO:0000313|EMBL:EGD32169.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 65..303
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 352..678
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 688 AA; 75289 MW; 187434826FB0E478 CRC64;
MREKMARKKR KFDSHSITRR LYLLFGIVMF LFLALIARLG YMQVVNQDFY TDKLAKASKT
KITTSSVRGQ IYDATGKPLV ENTTKQVVTY TRDNRLTAGE IRATAQKLLT YVGVSDTEVT
DRQEVDYYLA DSAVYQEVVE KLPKDKKFDT DGNRLPESKI YKAAAESIDP KQLGYTDEEK
KAIVLFSQMN AISNFATGTI QTDPLTTEQV AVLASSSKEL PGISVSTGWD RKVLDTSLAS
IVGNISTEKT GLPAEEVDDY LKKGYSLNDR VGTSYLEKQY ESVLQGKRAE KEIHLDKNGN
MESVENISDG SKGDNLKLTV DLSFQQGVED ILKNAFNAEL ASGNATYSEG VYAVAMDPNT
GAVLAMAGIR HDLETGESSV DALGTMTNVF VPGSVVKAAT LTSGWENNAI SGNQVLTDQP
ISFGGTDSIT SWFTQYGSRA ITAQEALEYS SNTYMVQVAL KMMGTPYSAD MKLDFDELDP
SMKKLRSTFA EYGLGTSTGI DLPNESTGYL PDKFTFANYL TNSFGQFDNY TTLQLAQYAS
TVANNGKRVA PHIVEGIYGN SDQGGLGDLV QKIDTKELNQ VNISDEDMSI IKQGFYQVVH
GSSGFTTGRT ISQGESVPIS AKTGTAETFV DKGKKEAINT NVVSYAPSEK PQIAVAVVFP
HNTDLSSTVS HSITRDIINL YNQQHPMN
//
