ID F0J243_ACIMA Unreviewed; 698 AA.
AC F0J243;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:GAN72424.1};
DE SubName: Full=Putative fatty acid oxidation complex alpha subunit {ECO:0000313|EMBL:BAJ79629.1};
GN OrderedLocusNames=ACMV_02820 {ECO:0000313|EMBL:BAJ79629.1};
GN ORFNames=Apmu_0001_13 {ECO:0000313|EMBL:GAN72424.1};
OS Acidiphilium multivorum (strain DSM 11245 / JCM 8867 / NBRC 100883 / AIU
OS 301).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Acetobacteraceae; Acidiphilium.
OX NCBI_TaxID=926570 {ECO:0000313|EMBL:BAJ79629.1, ECO:0000313|Proteomes:UP000007100};
RN [1] {ECO:0000313|EMBL:BAJ79629.1, ECO:0000313|Proteomes:UP000007100}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AIU301 {ECO:0000313|EMBL:BAJ79629.1}, and DSM 11245 / JCM 8867
RC / AIU301 {ECO:0000313|Proteomes:UP000007100};
RA Narita-Yamada S., Nakamura S., Ito N., Takarada H., Katano Y., Nakazawa H.,
RA Hosoyama A., Yamada R., Fujita N.;
RT "Whole genome sequence of Acidiphilium multivorum AIU301.";
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:GAN72424.1, ECO:0000313|Proteomes:UP000032662}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AIU301 {ECO:0000313|EMBL:GAN72424.1,
RC ECO:0000313|Proteomes:UP000032662};
RA Azuma Y., Higashiura N., Hirakawa H., Matsushita K.;
RT "Whole genome sequence of Acidiphilium multivorum AIU301.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
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DR EMBL; AP012035; BAJ79629.1; -; Genomic_DNA.
DR EMBL; BANA01000001; GAN72424.1; -; Genomic_DNA.
DR RefSeq; WP_013639279.1; NZ_BANA01000001.1.
DR AlphaFoldDB; F0J243; -.
DR KEGG; amv:ACMV_02820; -.
DR HOGENOM; CLU_009834_16_3_5; -.
DR OrthoDB; 7225138at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000007100; Chromosome.
DR Proteomes; UP000032662; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1.
DR PANTHER; PTHR23309:SF9; PEROXISOMAL BIFUNCTIONAL ENZYME; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140}.
FT DOMAIN 298..474
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 477..563
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 599..685
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 698 AA; 73436 MW; 9AED2012ABA2AB70 CRC64;
MSEQKVGLEI ANGVAVISID NPPVNALGHA VRAGLVEQLA AAEADASVRA IVLACKGRTF
SAGADITEFG KPPRAPGLHE VIERFDNCRK PVIAALFGTT LGGGLELALG CHYRVAVESA
RMGLPEVKLG LLPGAGGTQR LPRLIGPEKA VAAIVSGKMI GAKAALADGL IDAIVSDPVQ
GAIDFAHTVD PAKLVRVRDR SDKIAAAKAD PSAFEAAAAE ATKRLKGVEA PAACVEAVRN
SFTLPFDEGA RAEQQAFMRL VVGDQSRAQR HVFFAEREAQ KIPGIGPEVK GAKIGRAVVI
GGGTMGGGIA MNFANAGIPV TIVETDEAAL SRGLDRVRGT YDVSVQRGAL PAGTTEKRMA
LFSGSTDWGV MAEADIVIEA VFEELGLKKE VFARIDGIAR PGALLATNTS TLDVDAIAAA
TKRPGDVLGM HFFSPANVMK LLEIVRGKES SAQSIATAIA VGKTLGKVPV VVGNCDGFVG
NRMLARRTIE CERLMLEGAL PQQVDAVVKA FGFPMGPFAM GDLAGLDVGW RIRKHRGATA
PVSDALCEMG RFGQKTGRGY YIYENGSRVP TPDPEVEALI SEKATALGIT RRAISDQEIL
ERMTYPMINE AARILEEGIA IRPSDVDVVW VYGYGWPVWR GGPCFHADLV GLKEIAARLE
HYAQAVGDET LAPCALLRRL AAAGQGFADF AQDAKAAS
//
