ID   F0NF94_SULIR            Unreviewed;       837 AA.
AC   F0NF94;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   SubName: Full=Integral membrane protein, putative {ECO:0000313|EMBL:ADX85598.1};
GN   OrderedLocusNames=SiRe_1534 {ECO:0000313|EMBL:ADX85598.1};
OS   Sulfolobus islandicus (strain REY15A).
OC   Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfolobus.
OX   NCBI_TaxID=930945 {ECO:0000313|EMBL:ADX85598.1, ECO:0000313|Proteomes:UP000002664};
RN   [1] {ECO:0000313|EMBL:ADX85598.1, ECO:0000313|Proteomes:UP000002664}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=REY15A {ECO:0000313|EMBL:ADX85598.1,
RC   ECO:0000313|Proteomes:UP000002664};
RX   PubMed=21278296; DOI=10.1128/JB.01487-10;
RA   Guo L., Brugger K., Liu C., Shah S.A., Zheng H., Zhu Y., Wang S.,
RA   Lillestol R.K., Chen L., Frank J., Prangishvili D., Paulin L., She Q.,
RA   Huang L., Garrett R.A.;
RT   "Genome analyses of icelandic strains of Sulfolobus islandicus, model
RT   organisms for genetic and virus-host interaction studies.";
RL   J. Bacteriol. 193:1672-1680(2011).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; CP002425; ADX85598.1; -; Genomic_DNA.
DR   RefSeq; WP_014514035.1; NC_017276.1.
DR   AlphaFoldDB; F0NF94; -.
DR   STRING; 930945.SiRe_1534; -.
DR   GeneID; 12418480; -.
DR   KEGG; sir:SiRe_1534; -.
DR   eggNOG; arCOG02175; Archaea.
DR   HOGENOM; CLU_345038_0_0_2; -.
DR   Proteomes; UP000002664; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        27..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        324..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        348..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        377..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        424..446
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        452..476
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        512..529
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        666..686
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        693..714
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        720..745
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        766..786
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        798..821
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          287..467
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
FT   DOMAIN          669..828
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
SQ   SEQUENCE   837 AA;  95023 MW;  DC3B6F3D3FC3E6A1 CRC64;
     MVTNVKLVFP QYFLLYIKSR NNVKNGLVSL VLWLLLIMIL LHFAIKTPSL FTYSDSPFLS
     SSVQSVRADK IVTNYFHIGN VDNLYIIINS SSYNQALQEI YSNLYLLNNA TVITPNDYVS
     MLKTEYLSYL GLNEKNFSST ISQLYENLTR LKLYLISNFQ YFEYQLNITF GLPLHNFTSN
     ICPTYKENFD KVNGSLLEKA RYAGYLTFKD PFLFYFGFNN YTNYTLALKF LIQFNNYTSL
     IERILKTQNI TSVNESNVIF NNITTAFNSS FHKGTLWLFI INVPSNESLT NINQFTESLR
     NAYVIGHLAY YAQSAYYTQS NVEIIDITTI ILVMILLILL VRSIVPILIL ISSAGTSLLL
     AYGLMYMETL LGYKIYYISG LVAPPIVFGL NIDYGILLIY RYFEEINKNN LDALLYALKN
     SIKGILLSGI SITIGFSSFI LSPSALLQNI GIALVTSSIS ALIPAVFFTY TLLLVIPQIY
     LSFPRRKLPS ITDIRQRYLY KLSNFAVRHN KLLVILMLVS IVIFIFYFPS IHTNVNIDEI
     LPPHANSLVG TKVLNQLYNY SIDYIILYGS PKANYTLIYN LTKTLIDQGN LVYGPMSLGS
     QIIVNNSNLY DHFHQGNYTL LIIYLKYPVF SNGAINLTNW LISKGFLVGG DNAQRIDIVN
     NTVSTYFSYT LPLTIILIVI YLFMILGSIL LPLRLSLTVG LSSLLGAFTV ALVYNSPYWL
     SPLVIFALLF SLGIDYDMFI IIRLFDEMKN DDDINSAIVR SVENTGLVVT TCGLILAGAF
     FSLMVANMRF LQEIGLGVGV SILFDTFVVR PILVPAIISI LKKYNFWPFK ARKFLYT
//