ID F0RWC2_SPHGB Unreviewed; 298 AA.
AC F0RWC2;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Dihydrodipicolinate synthase {ECO:0000313|EMBL:ADY13479.1};
DE EC=4.3.3.7 {ECO:0000313|EMBL:ADY13479.1};
GN OrderedLocusNames=SpiBuddy_1654 {ECO:0000313|EMBL:ADY13479.1};
OS Sphaerochaeta globosa (strain ATCC BAA-1886 / DSM 22777 / Buddy)
OS (Spirochaeta sp. (strain Buddy)).
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Sphaerochaetaceae;
OC Sphaerochaeta.
OX NCBI_TaxID=158189 {ECO:0000313|EMBL:ADY13479.1, ECO:0000313|Proteomes:UP000008466};
RN [1] {ECO:0000313|Proteomes:UP000008466}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1886 / DSM 22777 / Buddy
RC {ECO:0000313|Proteomes:UP000008466};
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Zeytun A., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N.,
RA Ivanova N., Mikhailova N., Pagani I., Ritalahti K.M., Loeffler F.E.,
RA Woyke T.;
RT "Complete sequence of Spirochaeta sp. Buddy.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DapA family.
CC {ECO:0000256|PIRNR:PIRNR001365}.
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DR EMBL; CP002541; ADY13479.1; -; Genomic_DNA.
DR RefSeq; WP_013607329.1; NC_015152.1.
DR AlphaFoldDB; F0RWC2; -.
DR STRING; 158189.SpiBuddy_1654; -.
DR KEGG; sbu:SpiBuddy_1654; -.
DR eggNOG; COG0329; Bacteria.
DR HOGENOM; CLU_049343_5_1_12; -.
DR OrthoDB; 9771791at2; -.
DR Proteomes; UP000008466; Chromosome.
DR GO; GO:0008840; F:4-hydroxy-tetrahydrodipicolinate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR CDD; cd00408; DHDPS-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR PANTHER; PTHR42849; N-ACETYLNEURAMINATE LYASE; 1.
DR PANTHER; PTHR42849:SF1; N-ACETYLNEURAMINATE LYASE; 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR PRINTS; PR00146; DHPICSNTHASE.
DR SMART; SM01130; DHDPS; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365};
KW Reference proteome {ECO:0000313|Proteomes:UP000008466}.
FT ACT_SITE 136
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT ACT_SITE 164
FT /note="Schiff-base intermediate with substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT BINDING 209
FT /ligand="pyruvate"
FT /ligand_id="ChEBI:CHEBI:15361"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ SEQUENCE 298 AA; 32083 MW; 6987F230ED45A391 CRC64;
MNFEAKGIIT AMVTPLTADY KIHEKGLRKL VNYMIDGGVH GLFVVGTSGE FYGFSPEQRR
DAFQICIDEA KGRVPVYAGV NGITTAEAVG YAQMAEEAGA DAISVLTPMF ISVTQAELYQ
HYADIAASTK LPMLLYNNVG KTNVNIGVDT VVKLSKIKNI VGVKDSSGDF TLTSEYIRNT
YQAEKPFYVL SGRDTLIHAC LCYGGHGAIT ACANIAPRLM ADIYDKYVSG DVAGSLEAQY
RIAPVRMAFN LGSFPTILKE SLELLGIDAG PCFAPVGPMS IESKELLKKA LIQAGVLN
//
