ID   F0T893_METLA            Unreviewed;       646 AA.
AC   F0T893;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   SubName: Full=TrkA-N domain protein {ECO:0000313|EMBL:ADZ08505.1};
GN   OrderedLocusNames=Metbo_0253 {ECO:0000313|EMBL:ADZ08505.1};
OS   Methanobacterium lacus (strain AL-21).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanobacterium.
OX   NCBI_TaxID=877455 {ECO:0000313|EMBL:ADZ08505.1, ECO:0000313|Proteomes:UP000007490};
RN   [1] {ECO:0000313|Proteomes:UP000007490}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AL-21 {ECO:0000313|Proteomes:UP000007490};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Chertkov O., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA   Kyrpides N., Ivanova N., Mikhailova N., Pagani I., Cadillo-Quiroz H.,
RA   Imachi H., Zinder S., Liu W., Woyke T.;
RT   "Complete sequence of Methanobacterium sp. AL-21.";
RL   Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADZ08505.1, ECO:0000313|Proteomes:UP000007490}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AL-21 {ECO:0000313|EMBL:ADZ08505.1,
RC   ECO:0000313|Proteomes:UP000007490};
RX   PubMed=24449792; DOI=10.1099/ijs.0.059964-0;
RA   Cadillo-Quiroz H., Brauer S.L., Goodson N., Yavitt J.B., Zinder S.H.;
RT   "Methanobacterium paludis sp. nov. and a novel strain of Methanobacterium
RT   lacus isolated from northern peatlands.";
RL   Int. J. Syst. Evol. Microbiol. 64:1473-1480(2014).
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DR   EMBL; CP002551; ADZ08505.1; -; Genomic_DNA.
DR   RefSeq; WP_013643856.1; NC_015216.1.
DR   AlphaFoldDB; F0T893; -.
DR   STRING; 877455.Metbo_0253; -.
DR   GeneID; 10276685; -.
DR   KEGG; mel:Metbo_0253; -.
DR   eggNOG; arCOG01958; Archaea.
DR   eggNOG; arCOG01968; Archaea.
DR   HOGENOM; CLU_430009_0_0_2; -.
DR   Proteomes; UP000007490; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR   GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 3.30.1340.20; 3H domain; 3.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR035922; 3H_dom_sf.
DR   InterPro; IPR004173; 3H_domain.
DR   InterPro; IPR013099; K_chnl_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003148; RCK_N.
DR   PANTHER; PTHR43833:SF9; POTASSIUM CHANNEL PROTEIN 2-RELATED; 1.
DR   PANTHER; PTHR43833; POTASSIUM CHANNEL PROTEIN 2-RELATED-RELATED; 1.
DR   Pfam; PF02829; 3H; 3.
DR   Pfam; PF07885; Ion_trans_2; 1.
DR   Pfam; PF02254; TrkA_N; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF75500; Putative transcriptional regulator TM1602, C-terminal domain; 3.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR   PROSITE; PS51201; RCK_N; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007490};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        77..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          124..248
FT                   /note="RCK N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51201"
SQ   SEQUENCE   646 AA;  72895 MW;  65413C8E0226EB69 CRC64;
     MRPPYLPILP LSKDAADEPY ILAFYAIIGV LVLILYGIVG SIYIMKLDPL NSLYFTVQTI
     ATVGFGDIQP ITPLQKIFTI TLVMGGVALL AYAFTLTITV VTMTVEEIAS GAKQRKMIAA
     YNDHFVLCGY GRVGSAVHKE LQKRNIQVVI IEKNKDVVEK ELWQDPHVLA IPGDATDENI
     MIDAGIKRAR GVIITTGEDV DNLFITLTAR EISPKIWIVT RASKAENVRR LYRSGADKVI
     SPETSGAEDI YFASMEPTIM KITVKHSVED IRKESEIILK YGCTLENIEY HLPEFTEPLA
     RKVGVSDISQ LNRFLTSLEN EQSRKKSLEN IYESVSGIHS HWISGPNKES LDKVTSQLKK
     EGILLGINLN EDEIMEVTKK NGRMVEVVLK PEIKITESHG VRDIKEESQI ILKHGCTIED
     IEYYLPGFHE PLKRKIGLSN NEEMDRFLTK LNQDPERMES LERLYTISGG GIHSHIISGP
     DTESLRKVET ELKTKGFLLG VNLTPAEIKQ KITEFGRVSE LLVRHRPSEL DDKRIIIENG
     GRILDSKHYL PGLRQVVTRN LYLKDETDLV KCEEEYKKPD ARRSLETLSQ ISRQVHSHTV
     SARDAKTIMK IVQELTKAGI LLGVDLPLDE IWTIVESEKI EEFCIQ
//