ID F0U8W3_AJEC8 Unreviewed; 1407 AA.
AC F0U8W3;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
GN ORFNames=HCEG_00327 {ECO:0000313|EMBL:EGC40965.1};
OS Ajellomyces capsulatus (strain H88) (Darling's disease fungus) (Histoplasma
OS capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=544711 {ECO:0000313|Proteomes:UP000008142};
RN [1] {ECO:0000313|Proteomes:UP000008142}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H88 {ECO:0000313|Proteomes:UP000008142};
RA Champion M., Cuomo C., Ma L.-J., Henn M.R., Sil A., Goldman B., Young S.K.,
RA Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B.,
RA Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Klein B.,
RA McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J., Nusbaum C., Birren B.;
RT "Annotation of Ajellomyces capsulatus strain H88.";
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS990636; EGC40965.1; -; Genomic_DNA.
DR STRING; 544711.F0U8W3; -.
DR VEuPathDB; FungiDB:I7I53_08292; -.
DR HOGENOM; CLU_000288_6_16_1; -.
DR OMA; STLEGHC; -.
DR Proteomes; UP000008142; Unassembled WGS sequence.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 4.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR031359; NACHT_N.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22847:SF748; TRANSCRIPTIONAL REPRESSOR TUP11; 1.
DR PANTHER; PTHR22847; WD40 REPEAT PROTEIN; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17100; NACHT_N; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 11.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS50837; NACHT; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008142};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 368..517
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REPEAT 827..868
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 926..958
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1013..1044
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1054..1086
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1177..1210
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1219..1260
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 13..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1407 AA; 157285 MW; AF4C3DFAD6471873 CRC64;
MPLRARLKRL WGKHRPRTTK NATTTVNANP TPESHFPKLG PDDSAIFVAA STTVLTSPES
LKETRSLDPG PTLETVHTQN DTLRSSQDLK LSSLWDEAYD ELRKENAKLV DAYEQDLFSI
QNLGQQAPKG EDREIQLQKL LDSKLQNIEN SQMKISIHGK DVVIRDKARK VVHSILSVKD
YIGSIAFAEP HAALAWAGIL IILPVITNPI TQAEYGTEGL EYISELLVRC KVTEDTYREN
LACVLATSSP SIPAYLVELN ASFRAKTISI YSQILKYQIS FSQQCSRSGL FRFLRDYVIA
DDWQGMLESI KGTEEDISRV LDSFDSRTLK KIDEQVSVLR SNADKSLDLL LETKAGVEHW
GDGHREECMF WIKGLAGTGK STLARTIAHH FNEKGRLGAS FFFSRGKKDL GDATAILTTI
AVQLAEALPD LKNDICDVIE KHGDIGQQPL YNQWRELIFQ PLLRLDRKLL LPIVLVFVLD
ALDECEGDEH LGEILRLLTE LKSLKILRVK VLLTSRPERS IYASFRELPD IVHHDLTLHS
VPKVVIDGDI SIFLRYELGK IQSKRRIDTS WPGDESIQTL VQRADRLFIY AATVCRFIGE
SRFPEKRMSE ILQTESMSRS STSELDKMYS EILKHVLDEG SDEDKEDMAG LFKQIVGSII
VLFEALPKSA LTSTLDLPST DITEILEALH SVLDIPDDEN MPIQLFHLSF RDFLFSEERC
ANPTFTIKEE AAHGGLWKHT FLKISIEDIS FSPDGDFLIS SGGNLINAWD TTTGAFRYAI
PDISQSTFAL KRQEVLSPDG QFLACTSHFD DKIRLWDLKR IAIHSTLEGH VDYVISIAFS
PDGEYIVSTS LDKSIRLWEV KKGRSKILFS GKSDLLLEKS QSLSFETRTN GTIFSPNGEF
IAGYIHGLGH DQVQLWDAKT NCLVGTLPHP RFILALAFSY DGKFIASACS DGTVRIWDPR
TATLCGILTQ VKSGYADCIS PFAFSPDGQS IACISHGAVE IWDLKSLSLC GTIENDTEAI
TCITFSPDSR LLAAASGRFL KFWDRQTKIL CGMLAGHTSK ITTLKFSPNG QFVASGSLDN
SVRLWDTMGL GIPSSIIQTH ISEIKFTGSG HYVVSYLSDE TTELRDPSTG VPMFTLPDFL
QFSDKVEFSP VNNLLAYTDD DTVNLWNMAT RKFYGSLTIT DRVVKTIAFS PDGNDLAVSY
QNHAIVIWDL MIKKRRYVLK GHADDVYKLE YSSDGHLLVS ASRDDSLRLW DPATGELIGL
LGRRKGRIWD MAVSSDAKAI ICISGHFVTV WDSNTKLIKM ELDLKDKQVG DGVGSPIPLP
SLFEYLDMLP LSAFDWKEDK LVIRADPLCV KKPWVAYQLQ AVLWLPGGYR PIRGNSTSIH
GNTIALTGQS NSLMLIKLDL KSIPSKY
//
