ID F0UJ03_AJEC8 Unreviewed; 819 AA.
AC F0UJ03;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Ribosome biogenesis protein TSR1 {ECO:0000313|EMBL:EGC46500.1};
GN Name=TSR1 {ECO:0000313|EMBL:QSS57126.1};
GN ORFNames=HCEG_05715 {ECO:0000313|EMBL:EGC46500.1}, I7I53_05529
GN {ECO:0000313|EMBL:QSS57126.1};
OS Ajellomyces capsulatus (strain H88) (Darling's disease fungus) (Histoplasma
OS capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=544711 {ECO:0000313|Proteomes:UP000008142};
RN [1] {ECO:0000313|Proteomes:UP000008142}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H88 {ECO:0000313|Proteomes:UP000008142};
RA Champion M., Cuomo C., Ma L.-J., Henn M.R., Sil A., Goldman B., Young S.K.,
RA Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B.,
RA Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Klein B.,
RA McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J., Nusbaum C., Birren B.;
RT "Annotation of Ajellomyces capsulatus strain H88.";
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EGC46500.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H88 {ECO:0000313|EMBL:EGC46500.1};
RG The Broad Institute Genome Sequencing Platform;
RA Champion M., Cuomo C., Ma L.-J., Henn M.R., Sil A., Goldman B., Young S.K.,
RA Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B.,
RA Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Klein B.,
RA McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J., Nusbaum C., Birren B.;
RT "Annotation of Ajellomyces capsulatus strain H88.";
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:QSS57126.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=H88 {ECO:0000313|EMBL:QSS57126.1};
RA Voorhies M., Cohen S., Shea T.P., Petrus S., Munoz J.F., Poplawski S.,
RA Goldman W.E., Michael T., Cuomo C.A., Sil A., Beyhan S.;
RT "Chromosome-level genome assembly of a human fungal pathogen reveals
RT clustering of transcriptionally co-regulated genes.";
RL Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Bms1-like GTPase family. TSR1 subfamily.
CC {ECO:0000256|ARBA:ARBA00038288}.
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DR EMBL; DS990639; EGC46500.1; -; Genomic_DNA.
DR EMBL; CP069106; QSS57126.1; -; Genomic_DNA.
DR AlphaFoldDB; F0UJ03; -.
DR STRING; 544711.F0UJ03; -.
DR VEuPathDB; FungiDB:I7I53_05529; -.
DR HOGENOM; CLU_009858_1_0_1; -.
DR OMA; MNLPRFK; -.
DR Proteomes; UP000008142; Unassembled WGS sequence.
DR Proteomes; UP000663419; Chromosome 5.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR012948; AARP2CN.
DR InterPro; IPR039761; Bms1/Tsr1.
DR InterPro; IPR007034; BMS1_TSR1_C.
DR InterPro; IPR030387; G_Bms1/Tsr1_dom.
DR PANTHER; PTHR12858:SF1; PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG; 1.
DR PANTHER; PTHR12858; RIBOSOME BIOGENESIS PROTEIN; 1.
DR Pfam; PF08142; AARP2CN; 1.
DR Pfam; PF04950; RIBIOP_C; 1.
DR SMART; SM00785; AARP2CN; 1.
DR SMART; SM01362; DUF663; 1.
DR PROSITE; PS51714; G_BMS1; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008142};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517}.
FT DOMAIN 88..247
FT /note="Bms1-type G"
FT /evidence="ECO:0000259|PROSITE:PS51714"
FT REGION 40..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 429..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 819 AA; 91610 MW; E10FCF1F00215C62 CRC64;
MAPSAVAVPH HHRNTTKSIN KAFKSKHMSK GTLRDLSKGK IEERGSRKTP HQQLMSKLDR
RNQARQKQRL KHKNQSESVS IFSGQNGASK HVAVIPLADT VNTEAAVRSL NESLDISETD
IQGRMYRVRI ERFKQNVLYI PTRKDLISAL DTCRLADFVI FILPADNKLD EGAKLMLRAI
EGQGISNVLA VVQGLEKITP PKKRQQFTAS LKCFVAHFFP TLDKVHSLDS RQECSNIVRG
ICTATPKGIR WRDDRSWMLI ESVLWPESSS EASGEVIVTG VVRGRGLKAD RLVHIPTWGD
YKITSITAAP SLSLKQREAD GGMSISNTVE QQVLDQPSVD CDDMATVAPE EVVMMDDTIS
MADTAKKGVL LDDHHYFSDG DDKHASRPRR LPKGTSDYQA AWYLDDVSDS GSDLVDEMDD
IDEGMDLDTP AGPEDGFFNP DNRDTMTEAG PSEYPQSEMF LDPSPEDEAQ QIEEYRASRK
NEAKDDLEFP DEIELHPSTV ARERLGRYRG LKSFKMSRWE VEEDRAHEPE DWNRLLQVVD
YKGSKNQCLR EALVGGVKAG TRVNVHLSDV PLHLKSLPSQ PTSLFSLLRH EHKLAVVNIN
MSLNSTVEEP LKSKEELIIQ CGPRRLVIKP IFSAAGNTPN NVHKFDRYLH PGRSAVATFI
GPVSWGSIPV LVFKKTATTA TDAEAMDPST DNSGNTLPVT SSSNELENWE LIGSGTTIAP
DHSRVVAKRV ILTGHPYKIH KKVVTVRYMF FNAEDVNWFK ALQLWTKRGR SGYIKESLGT
HGYFKATFDA KINPQDAIGI SLYKRVFPRK AVAWGQEAH
//
