ID F0UP51_AJEC8 Unreviewed; 1087 AA.
AC F0UP51;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=ATP-dependent DNA ligase {ECO:0000313|EMBL:EGC46910.1, ECO:0000313|EMBL:QSS53089.1};
GN ORFNames=HCEG_06125 {ECO:0000313|EMBL:EGC46910.1}, I7I53_00241
GN {ECO:0000313|EMBL:QSS53089.1};
OS Ajellomyces capsulatus (strain H88) (Darling's disease fungus) (Histoplasma
OS capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=544711 {ECO:0000313|Proteomes:UP000008142};
RN [1] {ECO:0000313|EMBL:EGC46910.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H88 {ECO:0000313|EMBL:EGC46910.1};
RG The Broad Institute Genome Sequencing Platform;
RA Champion M., Cuomo C., Ma L.-J., Henn M.R., Sil A., Goldman B., Young S.K.,
RA Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B.,
RA Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Klein B.,
RA McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J., Nusbaum C., Birren B.;
RT "Annotation of Ajellomyces capsulatus strain H88.";
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000008142}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H88 {ECO:0000313|Proteomes:UP000008142};
RA Champion M., Cuomo C., Ma L.-J., Henn M.R., Sil A., Goldman B., Young S.K.,
RA Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B.,
RA Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Klein B.,
RA McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J., Nusbaum C., Birren B.;
RT "Annotation of Ajellomyces capsulatus strain H88.";
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:QSS53089.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=H88 {ECO:0000313|EMBL:QSS53089.1};
RA Voorhies M., Cohen S., Shea T.P., Petrus S., Munoz J.F., Poplawski S.,
RA Goldman W.E., Michael T., Cuomo C.A., Sil A., Beyhan S.;
RT "Chromosome-level genome assembly of a human fungal pathogen reveals
RT clustering of transcriptionally co-regulated genes.";
RL Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC {ECO:0000256|ARBA:ARBA00007572}.
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DR EMBL; DS990640; EGC46910.1; -; Genomic_DNA.
DR EMBL; CP069104; QSS53089.1; -; Genomic_DNA.
DR AlphaFoldDB; F0UP51; -.
DR STRING; 544711.F0UP51; -.
DR VEuPathDB; FungiDB:I7I53_00241; -.
DR HOGENOM; CLU_004299_1_0_1; -.
DR OMA; LRRHIMR; -.
DR Proteomes; UP000008142; Unassembled WGS sequence.
DR Proteomes; UP000663419; Chromosome 3.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:InterPro.
DR GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd08039; Adenylation_DNA_ligase_Fungal; 1.
DR Gene3D; 1.10.3260.10; DNA ligase, ATP-dependent, N-terminal domain; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR InterPro; IPR036599; DNA_ligase_N_sf.
DR InterPro; IPR029710; LIG4.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR PANTHER; PTHR45997:SF2; ATP DEPENDENT DNA LIGASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G02430); 1.
DR PANTHER; PTHR45997; DNA LIGASE 4; 1.
DR Pfam; PF01068; DNA_ligase_A_M; 1.
DR Pfam; PF04675; DNA_ligase_A_N; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:EGC46910.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008142}.
FT DOMAIN 393..535
FT /note="ATP-dependent DNA ligase family profile"
FT /evidence="ECO:0000259|PROSITE:PS50160"
FT REGION 724..751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 829..851
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1052..1071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..747
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 835..851
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1087 AA; 121436 MW; 98D7944F538EC2F9 CRC64;
MGFKFSYVCD LFTSLENNLT LRASTASRHR NPDVATIANW FSQHGKQIHG GETDRLALLS
CLFPERRPER VFGLKEPSLV KIIGRCLLLG ISRRQALDSY KICGNGDLGQ CVERVMRQAE
NDNPEDSGVT VEDIDTVLNH IASRCRFSGP DVRRRRTAAG VDEVLGPILR HLTSCEAKWL
IRIILKDLSP LTLPARLILQ NFHFLLPDLL LLQDSLGAAV ALLSRDPMKR FPWRPDPDYA
KLLASFAFSR ISLDVGVKVG RPTFYKARGI KHCCKMAGKR TMSVERKYDG EYCQIHVDLS
KGSGCIQIFS KSGKNSTMDR VGIHSTVKEC LRIGKVGCKI SRNCILEGEL LVWSDVESKI
LPFHKLRKHV IRSGSFIGTE NDSPPHSYEH LYIMLFDVLL IDDQACLPKS YRERRALLKE
ISHPIDGRAG IAEQEYIDFS LPESQEMLTT AFATAISQRW EGLVLKASDE PYFVIEQQEH
SNFGHWIKLK KDYIAGIGDT ADFALIGARY DAREAAKLQS IKGVQWTSFF VGCRDTGSKY
PYDARPLFRV VDVLNRHNVN IQLLRTLNQS GRFCSCDVDD EDAPFIIKTD QIQLPKVQVL
FKTPFVVEMV GSGFEKPAGA NYFTLRFPRV LKIHMDRDVE DATTLEELQV LAEAANSVPK
DELSQNTAWW AERLDAVDGE PGYIIDTSEH SPISVVSISQ PTNLENAPSD TPLRRHLVAN
EQKVVTSMGK RREIDVSPRD SRKVSRKQPK IARSLSPCIA IHSDHTQTTA NTHLSHSQDS
VGARHLSNIS NLSQPNPIPT YASVGDCEDA VATTSLGNKI ECSTTLRKLD EDGLSRSPQP
SQQKSAGQNP YQEQQCFAQL ELGLAGSSPS VGPLDTLSFL SETPILLGTG VSRDKVDSIP
LDPKLLTTSI TEFLEKLLDP NFPDKSHFHH SNPDAAQNFS KCSGIVLVES NTTKASQAAS
DIARIGNALA INQRTGRLPS KRGKLIFLRC EAMLQHGLFE RNQAGHPENI RERWESHGKQ
LFAGSLEWGY GISRQRKRRK FDFKSTDVDC EESSRVGRTK ANDSPSPPTM GVDVQLSWDW
REVLSLV
//
