ID F0VDY2_NEOCL Unreviewed; 1443 AA.
AC F0VDY2;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=DEAD/DEAH box helicase, putative {ECO:0000313|EMBL:CEL65887.1};
DE SubName: Full=Putative DEAD/DEAH box helicase {ECO:0000313|EMBL:CBZ51925.1};
GN ORFNames=BN1204_017170 {ECO:0000313|EMBL:CEL65887.1}, NCLIV_017170
GN {ECO:0000313|EMBL:CBZ51925.1};
OS Neospora caninum (strain Liverpool).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Neospora.
OX NCBI_TaxID=572307 {ECO:0000313|EMBL:CBZ51925.1, ECO:0000313|Proteomes:UP000007494};
RN [1] {ECO:0000313|EMBL:CBZ51925.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ51925.1};
RA Aslett M.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBZ51925.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ51925.1};
RA Reid A.J., Sohal A., Harris D., Quail M., Sanders M., Berriman M.,
RA Wastling J.M., Pain A.;
RT "Comparative genomics and transcriptomics of Neospora caninum and
RT Toxoplasma gondii.";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000007494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|Proteomes:UP000007494};
RX PubMed=22457617; DOI=10.1371/journal.ppat.1002567;
RA Reid A.J., Vermont S.J., Cotton J.A., Harris D., Hill-Cawthorne G.A.,
RA Konen-Waisman S., Latham S.M., Mourier T., Norton R., Quail M.A.,
RA Sanders M., Shanmugam D., Sohal A., Wasmuth J.D., Brunk B., Grigg M.E.,
RA Howard J.C., Parkinson J., Roos D.S., Trees A.J., Berriman M., Pain A.,
RA Wastling J.M.;
RT "Comparative genomics of the apicomplexan parasites Toxoplasma gondii and
RT Neospora caninum: Coccidia differing in host range and transmission
RT strategy.";
RL PLoS Pathog. 8:e1002567-e1002567(2012).
RN [4] {ECO:0000313|EMBL:CEL65887.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CEL65887.1};
RX PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT Transcript Features.";
RL PLoS ONE 10:e0124473-e0124473(2015).
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DR EMBL; FR823387; CBZ51925.1; -; Genomic_DNA.
DR EMBL; LN714480; CEL65887.1; -; Genomic_DNA.
DR RefSeq; XP_003881958.1; XM_003881909.1.
DR GeneID; 13444634; -.
DR VEuPathDB; ToxoDB:NCLIV_017170; -.
DR eggNOG; KOG0346; Eukaryota.
DR InParanoid; F0VDY2; -.
DR OrthoDB; 206705at2759; -.
DR Proteomes; UP000007494; Chromosome VI.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR PANTHER; PTHR47959:SF13; ATP-DEPENDENT RNA HELICASE RHLE; 1.
DR PANTHER; PTHR47959; ATP-DEPENDENT RNA HELICASE RHLE-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR PROSITE; PS51195; Q_MOTIF; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:CBZ51925.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007494};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..1443
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007655073"
FT DOMAIN 345..373
FT /note="DEAD-box RNA helicase Q"
FT /evidence="ECO:0000259|PROSITE:PS51195"
FT REGION 187..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 636..670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 882..915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 935..956
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1096..1121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1133..1177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1266..1420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 547..581
FT /evidence="ECO:0000256|SAM:Coils"
FT MOTIF 345..373
FT /note="Q motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00552"
FT COMPBIAS 254..287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..334
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..670
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 882..907
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1284..1379
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1395..1410
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1443 AA; 155233 MW; 812D219DB051BDB4 CRC64;
MPAASRPSRR RRLGKRLLAI VSLAVQITLG SASTRPGNRS KVLAFSSTFS SFSLPTPPPL
CWKAFAHNED RRPCSLAASA FETLEFTEHS LSPSRPARTR PAGPRTTSLK FSTLAARHAS
RVSLLEMVFP LESCRNTCVP SSLSPVPRRA VPPATSSQAL PGLRTSLSCI RAGTTANWEG
PSALQLASST GENAGQGRAV RSAREVASQT RSLPGEEGGF SGRRPLRAGK QASVDGGGEE
EEVREEGSEA WQSKEKGPSH SSPLSSHSAP LLGSATRPSS RSPPSRRPGS SPESPRLSPP
APSGSLSSSS SSSSSSSSSS SSSSSSSSSP LAPQDSPSGP FPCLPTFAGL PLPPYLSAAL
VNQGISSPTG IQQAALPPLA AGEDLLLHSE TGSGKTFAYL LPLLHWHHHA NCAADPPATD
PRAGAYLLQN CPGVQTREEA ANRRKNQLWR RRDSRRKNGF LGTAAEDGAD EEELSTAEHH
LSHAACLDAP EVANALRRAT ACSLIVTPTR ELAVQVAHEV HTLLRTNFSV SEERAPEERG
ACGLSLLRRT VEAFAAAQED LEAAERAAED LKGAVAVAAR AGENRAAALL ARANQAEMRV
LAARDRLVMA RLALAQARGE GMRPRLLLVL GDPLAGSSGP GSRAPAPVPP GEARREAETA
EHFGSAREGR ATRLCGTEEA ARTFGTDTKR LPSWAREKLG SSLIVVGAAQ TLRRLLQRLG
AVNPDVLETF LKRIKHVVFD EADRLLQPLT RYAPLKTKTL RRSRPRPASL IFSSLLIAKK
PIFQRRRNVE KASPTSSLLL APPASLLPAV PACGALRRKA RRPAASSCRH SALSFLLRVF
RLPRGALVPC PSRTSANFQI IGASATVGRP LRRQLAEMLA MREALKKPES PTRRKDSEKA
RREGEEEDDE AYVSEEERKG MARVLRGLHA RGLVSPCGEE PRRGQAGNVV ESEKERGTRL
MKVVRPHASS AAANSPQGPT SLLVGLPSTL KHFLHATPRG NLATLVYETS LLLHQLQPQR
ALILLDKKHS VVSFLLQLQR LGIEHTQLLH EAFGFLSPRL TSRLKAARET PESPSLSPSS
LSPSRLHFHF GRRERLANAP SPSPPPSLVQ TAPLITSPSS PLSSPSLFSS LPSLGEVGDQ
AAPKQRVVSP SSEAVEVAGE PKGAWASRGV RPAREENQAE NARTLLLTSM ATARGLHFDN
LDCVILVGNV ENAREYQHLA GRAGRKGRPG NVICVSDSET QRSISSWAKK LGVTYHSSQR
LLFPASATDE PSHAEAESPQ QSFSDEASHE EWRVPRGVES DGHVERRRTQ REDGLEKADR
EVREVNGVER EDGLERHTEQ PGREAVAGQG DREAREERDA LWPERRRRNL EEGEREQAIS
AEAVPESVRA KNNGPGAGRR RDEETRETGT KVETAGTGAH AASAWDKLAN LSLPSFSSLV
SNM
//
