ID F0VH10_NEOCL Unreviewed; 615 AA.
AC F0VH10;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE SubName: Full=Rhoptry kinase family protein ROP17, putative {ECO:0000313|EMBL:CEL66989.1};
GN ORFNames=BN1204_027930 {ECO:0000313|EMBL:CEL66989.1}, NCLIV_027930
GN {ECO:0000313|EMBL:CBZ53004.1};
OS Neospora caninum (strain Liverpool).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Neospora.
OX NCBI_TaxID=572307 {ECO:0000313|EMBL:CBZ53004.1, ECO:0000313|Proteomes:UP000007494};
RN [1] {ECO:0000313|EMBL:CBZ53004.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ53004.1};
RA Aslett M.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBZ53004.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ53004.1};
RA Reid A.J., Sohal A., Harris D., Quail M., Sanders M., Berriman M.,
RA Wastling J.M., Pain A.;
RT "Comparative genomics and transcriptomics of Neospora caninum and
RT Toxoplasma gondii.";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000007494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|Proteomes:UP000007494};
RX PubMed=22457617; DOI=10.1371/journal.ppat.1002567;
RA Reid A.J., Vermont S.J., Cotton J.A., Harris D., Hill-Cawthorne G.A.,
RA Konen-Waisman S., Latham S.M., Mourier T., Norton R., Quail M.A.,
RA Sanders M., Shanmugam D., Sohal A., Wasmuth J.D., Brunk B., Grigg M.E.,
RA Howard J.C., Parkinson J., Roos D.S., Trees A.J., Berriman M., Pain A.,
RA Wastling J.M.;
RT "Comparative genomics of the apicomplexan parasites Toxoplasma gondii and
RT Neospora caninum: Coccidia differing in host range and transmission
RT strategy.";
RL PLoS Pathog. 8:e1002567-e1002567(2012).
RN [4] {ECO:0000313|EMBL:CEL66989.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CEL66989.1};
RX PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT Transcript Features.";
RL PLoS ONE 10:e0124473-e0124473(2015).
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DR EMBL; FR823389; CBZ53004.1; -; Genomic_DNA.
DR EMBL; LN714482; CEL66989.1; -; Genomic_DNA.
DR RefSeq; XP_003883036.1; XM_003882987.1.
DR AlphaFoldDB; F0VH10; -.
DR SMR; F0VH10; -.
DR GeneID; 13443113; -.
DR VEuPathDB; ToxoDB:NCLIV_027930; -.
DR eggNOG; KOG0612; Eukaryota.
DR InParanoid; F0VH10; -.
DR OrthoDB; 203636at2759; -.
DR Proteomes; UP000007494; Chromosome VIIb.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR027916; Kinase-like_dom_Apicomplexa.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24349; SERINE/THREONINE-PROTEIN KINASE; 1.
DR Pfam; PF14531; Kinase-like; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000313|EMBL:CEL66989.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000007494};
KW Transferase {ECO:0000313|EMBL:CEL66989.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 24..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 315..611
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 69..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 344
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 615 AA; 68509 MW; C3D3D08E9C83F3EF CRC64;
MPLSRFSVPA ASRTADQMAR CHQAWLNLAG GMTVCFLIVT ISCLYLESSA LPLRSRAKND
VFGGLEASAH RTQPRAGGAT HLPQRGTTSH FHSRGKPSWR NHGYASWSNN YTLLTEETAI
GSQHLARPTG LSLIENPGDI HDEGDAVAGA REERDVDAHL HPEDGAPFDR LALQGEGPLN
RHPQAQTGPA RSGLRTRIKQ NVGRLWRVGK RALQKLGQRA KQRIGEFVAR HVRPRLARLR
FWDAGRPPVV PPLKGNEPGQ ADVALVAARM QAGVRQKAFR EKNLTEAEKI IGSYLISSAE
KTWFSTVPGG RPIVLIKRGF IGGGGFGLVY HVEHPGTRQA YALKAFIRDD RSGMPLEGLS
ASIEEEFDVT NGFPPEWTPL RIYSELRFMV PILKLRVQGK PDFQDVRRHF RVASTCALFP
KAQGDLGELV RLLKDVDSDT AFRVRMSSTI QMVKLLARFH SFGLVHGDVK LQNFLVEQSG
LLLLSDFTKI IRGNSNYFPP VVTAAYMSPE MATCLVNRLR DDIAYTSRTD SWMLGISVYK
LWCGAYPFGI KASSRLTEVA GILLRVHTSL PDFSRCHHIP RQFRDMVRGF LRKSSVLRLD
PQQALEDIPL LQWTG
//
