ID F0VHL8_NEOCL Unreviewed; 5690 AA.
AC F0VHL8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=FYVE-type domain-containing protein {ECO:0000259|PROSITE:PS50178};
GN ORFNames=NCLIV_030000 {ECO:0000313|EMBL:CBZ53212.1};
OS Neospora caninum (strain Liverpool).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Neospora.
OX NCBI_TaxID=572307 {ECO:0000313|EMBL:CBZ53212.1, ECO:0000313|Proteomes:UP000007494};
RN [1] {ECO:0000313|Proteomes:UP000007494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|Proteomes:UP000007494};
RX PubMed=22457617; DOI=10.1371/journal.ppat.1002567;
RA Reid A.J., Vermont S.J., Cotton J.A., Harris D., Hill-Cawthorne G.A.,
RA Konen-Waisman S., Latham S.M., Mourier T., Norton R., Quail M.A.,
RA Sanders M., Shanmugam D., Sohal A., Wasmuth J.D., Brunk B., Grigg M.E.,
RA Howard J.C., Parkinson J., Roos D.S., Trees A.J., Berriman M., Pain A.,
RA Wastling J.M.;
RT "Comparative genomics of the apicomplexan parasites Toxoplasma gondii and
RT Neospora caninum: Coccidia differing in host range and transmission
RT strategy.";
RL PLoS Pathog. 8:e1002567-e1002567(2012).
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DR EMBL; FR823389; CBZ53212.1; -; Genomic_DNA.
DR RefSeq; XP_003883244.1; XM_003883195.1.
DR GeneID; 13443478; -.
DR VEuPathDB; ToxoDB:NCLIV_030000; -.
DR eggNOG; KOG0230; Eukaryota.
DR InParanoid; F0VHL8; -.
DR OrthoDB; 5481504at2759; -.
DR Proteomes; UP000007494; Chromosome VIIb.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0052742; F:phosphatidylinositol kinase activity; IEA:InterPro.
DR GO; GO:0046488; P:phosphatidylinositol metabolic process; IEA:InterPro.
DR Gene3D; 3.30.810.10; 2-Layer Sandwich; 1.
DR Gene3D; 3.50.7.10; GroEL; 1.
DR Gene3D; 3.30.800.10; Phosphatidylinositol Phosphate Kinase II Beta; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR027409; GroEL-like_apical_dom_sf.
DR InterPro; IPR027483; PInositol-4-P-4/5-kinase_C_sf.
DR InterPro; IPR002498; PInositol-4-P-4/5-kinase_core.
DR InterPro; IPR027484; PInositol-4-P-5-kinase_N.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45748; 1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED; 1.
DR PANTHER; PTHR45748:SF7; 1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF01504; PIP5K; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00330; PIPKc; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF52029; GroEL apical domain-like; 1.
DR SUPFAM; SSF56104; SAICAR synthase-like; 2.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007494};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 328..389
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 92..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 163..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 241..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 395..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 647..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 792..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 889..928
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 991..1023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1052..1158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1349..1370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1423..1448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1614..1656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1794..1858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1874..1934
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1977..2042
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2142..2237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2283..2364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2480..2504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2516..2552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2614..2640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2677..2715
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2763..2841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2892..2949
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3013..3122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3164..3198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3214..3264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3290..3369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3388..3472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3522..3620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3650..3709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3806..3829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3976..4049
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4077..4096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4165..4228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4307..4370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4393..4429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4461..4505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4588..4619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4973..5294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5471..5525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5561..5651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..201
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..411
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..453
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 810..827
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 998..1018
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1060..1079
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1123..1141
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1633..1656
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1800..1828
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1842..1858
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2006..2020
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2022..2036
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2142..2174
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2182..2202
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2209..2237
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2315..2334
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2336..2364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2516..2542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2785..2800
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2903..2917
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2927..2947
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3037..3061
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3082..3114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3164..3178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3214..3238
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3244..3260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3293..3313
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3393..3407
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3976..3996
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4000..4018
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4033..4049
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4171..4192
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4200..4216
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4307..4334
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4341..4359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4461..4483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4973..5006
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5007..5056
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5060..5092
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5145..5165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5183..5208
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5229..5256
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5488..5503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5603..5620
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5628..5651
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5690 AA; 606404 MW; D9D6449B247D25F3 CRC64;
MESPGVVACN ISFSLARFFA SNGPRRLGEY LTHGSSPAEP CCLVLLKNHA CPGCKCVLTL
SPAALSQFLT SSVSSSVRKC VVSRVQRRLV KRGRRGREAA ATPSSSPQVG VCSPTLRLAS
EGYGRSSDTM TFSTVSPCSP TPEAGDSCCP RFSACSSTVR RSRSSSFLTA DAPGGGEGAR
EDEEAKARGL TRPERDRLFS PRSSSARNPH ESLPLPSASS RSRTGYDRSA SPSLFTSFSS
LASPLSPPDP ALSSSRGAGT HQHLTPRELT PPSRFPPASV SSPSGASSSS FAAPRFVSLF
FSRDPRGEGT GASGLETTGR PTDWLMPDSK CSRCFACGVS FSTFTRRHHC RQCGLVFCHK
CCSCWGEGAP LGFGPGRVRV CGACSQLAQR DEEEARREQG ERAAICEHEQ EETEVEASEE
KETQTRRALP RGVRAFTTSS SREEEERKRT RRRASQSVCL SSRSASSFSS SGPAASISSR
WVPSPSAFCS AGEAAWRHLR GSVYLHCRLV GLSRLHARIL FDLTLSVIAP LRLPAASPSS
SPPSVFDFVK VKRLPGLSVS DSFFVHGVVF PLHLHCKQHT RLLLQRPRLL LLSSFLGLPR
QYPPSASPAS PGMPAGACSS LSKPSSLSSS AASFPLSEPS VSNAWPSPLA SAVPQAPSPA
SPASLSRPPG TKDPTKETTA FGAAAQTGAG QPGVSASLPG AAYTRMQILR EQEETYTGIV
IQKILALEPA LILTSDGASQ LVQAQLQALG ICLLVHVPPR TLRRVSRSSG APILSSLDRA
AALAVALREE QEKDADRRRA AEETGSARSS GDALRLTGTS QEAQPPSKRR QLPWGSCGVC
QICRPQPMCV ARPSLVFIAR CPSRAGATIC LRGRASSVLG AQAGDCACVS PEARPPSRTP
TGGRGLSPPD PERSSGAEYG KKDFQRSARA AQEVPVVDEL FLSKRVLQRA LVHAFSLRQE
LTLVASCCGR ESDDAPFQFL PDQLRAQPLT ARGAEGAAKR ETQPEKQRRF RDHPSARTPP
GERATCRLCR AGKKKEPSGA CWCRLTRQPV GASRAWRRGG GGAERADTGY EESEARARTE
CSDSGGVVAA QGCGERGRSG SREAHTSRPP APSARQLQAK PPSAPRRRRE TAQDESEQEA
HPVFSGKPPS PTQAMALPFR LSPSPASTAF LSACLFFDRF LQTPLCDWLR LSFSSPLHRP
SSLRLLAKLV SPQPLPVAAA RRLLLTSLSD LTSLDTRRSR TLALASSSSS SFSFSSSFPL
RFACRDGCAL PLEGERGLQV LQAGCRFDSE GSPEGCPPFE NAGERHRLGD WTAAFENAPR
RSSRRGTEGD WGRRLALVAG ENVECRFPVK RGGEDDDAAE NPHGRERDAE AACSWELRVE
KLGRGNRSPG TSETDPCASL ENARDLVAFG AFCAALQFRH TRVEGRESNP PPYPSVSSPR
RSSPSSLFRS FLSDPSLLGS QPSRACCGPR RLLPTRHPDA PLLEMQAALA AADLAGCSGS
SADSPGAPAA LDAAFAAWAQ RPSAWTESEK DRLFPLAVFL GAQLGPRLRQ VWPLHLLTLF
RTDSAQLSLI SSWSSGKQQC AAHLLRHDLP LLQLPPNREA PLSLWRKAWL QAADATNSTD
KKPGGTRATS GRRPDGDAGD QREDGKAASG ADAERRSWFE DACEGRSRGR RTSVAAWRDS
VDEWATAGSA EGPSERFGDL ALAAVLRGPE EAGWRTRERG EETEEARLPS LRDTVQKRCR
EAAAILHQKK CPAGSARCKR PLLQHALRMQ SLDSRIVVRF SLFSPEEHFP TFALPRASSP
QRLDLSSPSS ASSELSTEKK SASSVAPPDT CSPDDLREES ASSDLFTSSA SSSSSSLPLF
SSTSTTHACL SAEAVETPVP SSASEGQERR DLVARQPGAQ DADRRAGQEP GPAETPLEGD
GLHANGDGGG RRECEGESWL QALRRSLVFA HQPRNSDSQG YAETEAKGGA AKAACVSEPS
GVGAKAGEAS GRGARSGERR NLVAGSSFAT GDSGGSSPDR TCEKASGRER GGRLKVGRSS
KPRAQRWLHT VSTETSQSGV LFWQVCSACQ ALVLPCRMLG EEGNLPFSKF LELLLCNDSY
RGDGSCVSVF LESPRVRLRR EDRALQREKC EAALERRCEI QKETRGEEGE GEGEQCRDGG
LDRTRRRRRS RCTSTDGEGQ AVEQGTRRKE NRHPREDGKG SDAWIPEGGG GCEDKRRSEA
ADGDESAEHE GKVGGGERAG ERTFYFAFAG VVMSFAYEEV PIYTLRRHQL DRLRCLENPH
ASLLPRGEAP RASTLIGDSS RGTAVLTTDP DLPEGQSGDS RDRNSWRMKD ACSNEDEAST
PGTPKTRSGD PSSPSPFSAS SSVSSSASSA ASASAARFPS LSSPRDGSSS VLAIVHLLLC
GVLLPLASEA YFASRLTSVL SLASSLAAST GGESEKRERR SLVPQLFRLP RPFIGGASSR
SPSVRASQVP AASTLRPSAR LFSSSDLSSP SSRSSSDASS VPVSLTTVRD TNGYTSSCRV
PRSLLSATRP EPGASSCASP GGSTAHMPLG GADGDGQSRL APVGAGRRPA ACARHTVPRK
RAESLEKLAT GGARTPTFLD LFKTLRCLLL RLSEEEESGR PREGSGRDAA GNGRDFHRQH
FAPDAVSPTD EATMLLLDLV QDILQWTVEA MEARQASRLA DCEEANSPRT GRGYARKKRK
DSVSLAKSAS PRQPPAGMDT CVTFLAVLAS LLSPLLSLCD RYIFLFFLLA TADQRGVSPI
PLSGSARASG TRDGPHGDCS ASSWGLADSR KTQVSESHPQ LVSCEEGMGA ERDERNGRPP
SWSPSPRPSC GIALSPPVFS QTPRGRHALR AAQAFVRLTR RAAAVYRYFA RRAALLLLVS
CCSTWPTART WAPAGVRSGG AGDRRSVPRR GEPARGGGEM ETRNGSDGEA SAGSSNRQTQ
QPDSAWREAT QRAIVRSRLR ALEARFLCTS ALPDLLLLKE GWETLRGHLF EVYRTLVADM
FCVLKAATEM HTAVERDSPP EASHRTPSGQ RAFGSSPQDD AERHVEALES RPGEGRSRGA
PHSPEMEQTP DPEDPSPLPS FRLRSRSLSP QSEASAHQQS ATRDAQSSSD KTRGEAPSET
VRAAACHVDS AVSAGSSYSI VVAAKLRADP ASSLVSVFLS TAAPSASGLP SALSESASES
AARDPLPGPC RQDSAQRDMT RRLEAVHARL VASGREVARW EDGQRGRQAE RFRHALPSAS
ESARESALGR QSSESTGVSQ AKPGGLPFLA SALSPLLNLM ATPPLLPRSP ASSFAPSPAS
PALRATSTKR KGNVSDGLPP PPSLAMLDPR SGVSSEAGAA SVVCSPAVAS APPSPFASFG
RRVSSPSPSH AISSVALFEA LPPSVALAPR RGDASRGDSE QTRHADAMRE SVGTCAADTG
RPDDGDGRAP QMKGDTQTED SPDRATSQKG GREAANPQEP SALSGLKQRD SERLCQGWEG
QGAASADGDL VVVMKVLPRG RGDTLEVDDS CGETVKVSPF VPPASCSSPL LQLPRSGVSA
TPEERARIGD DSRVPSFFRF SPSSPGMSPS SRPPPSSPFS GTSSPHKTPH NLRASPSPPG
AVPVAPSPLG TNRRGGDPLV PRFFFAPSSG RRRAVSCEVL QREGERTRDC PPVPFTLVPH
TVGEGHERRG RSGAPAETAV AAARRRDQSR GCSFDSPWPG DPRGEMDAAD AADGDRADAL
LVCPVNGSGV GGTRERGQAG DGRIQFSIAA SRRRPSHDAR GDKEGHDQVG RIARAAPAVP
TGEPTPDANA PEGTVHLGMA FALPVASPAP SSPSSPGSRR RSGFPLPRET AAAVPDSHVL
FERVSAAVFD RLLEDAQLEM TRLVSSHESL LSSLHPASPP GVFTQLCFPP LARDRLPSPL
SRQNVSPLLR NPQRREAFSC SRASPSFASA GVHGVWVTAR DTDVGSVIAH ALLSAAMQRE
MAARWASWGS RARARSRPER ACASEESGES AEQAETLARR KSSAGDSASS SNFARTDTGP
RLAASGEMRG GEPKQQRGSK GAERGVDEEE DSRKMRLPCC GGRCAACRCR RRTGSLAPRS
DRVETPEETG DSEAGECDCC RGSCPVGVAR LRRLHRAGAF QETAGDAGNH LWGGDCDCPR
CGALRRLLQL AMHAPTDEHL ATGIASSGRD WRHDAGVKGK REGDRALKTR GSRSHEGQGP
VRTGGDDVDR RQKSEGHPSP SICGARTGKS LQKVHSEFHT QRFGGERGTE TRLAATHSGS
PSGWFLTSCF LSLPPLSAPY WRFDGVGSSP FAPLSSRFGC RLHALADPEV PGRDRPGWAR
HSRGGSRESS AVRSEARDSC LLQGPPSTGS GQTAHAQSGD GRGDSPETPE GLAIRWWRHG
GCGGHARGER CPAVDAGHRR KRHGVGSSGP AVEPPCPSSA SSCGSPACPG PFASRPELTE
GERPLAETWA LLRLFSGLSS ETPASATNES SACASSSSHI APVSPAAPAS AAGPSSRSVQ
PLSARQPGHF DFVEEREGGR NSTRILEGRA VRTLRNYLRL GKSASPSRHN EACRAQASPL
RACGNAKASF GWGDEERRVM REVITGPSSA MSAGCGREKE GDARHRARKG KRSFSPHGLT
GEASEHVQIL VQAKRGEANH EEEASQGVRE QADSPCLVTV YYAARFHAMR HLLCGDDMRF
CASLRTSQPV RLPGGKSGAH FSLTQDGQYI VKQLNKHEMR LLLSAEAGSA LFRHFAETLF
DQEPTTLTAL YGVFQLAFLN TKSKAFYVVM ENLRHGRARE DGFLSQLQSL SFLAPLAALL
RPVAEPAGHS GVAGGRGRRA PENPVFEATG EKGEEMTRMP QHDGGDAGTT CSSASGYADE
GVSVSTDASV ASDSAVADTD LGCSTGRTEP FSLASRVFRL FSSFALSSFP ASFQSAPASF
TAPAEPSRLL LFDLKGVGTL RYVRLDDKRS PMESSPGAHG DNAEEADLDA RGRAKERQEN
GEVSRRADCT KDAEEERDER GGRRSHGNAQ TDTTDAQPFC RQSGLATHSE SESGEPFFSE
THTAPDRRTS AATDMTPEGI SGDRRGRKAE TWDISGRQTG DGEDERRGYG CESEGTAGRA
GGLQGTAAGA EGTEGERDAG REEAPCWSSD QAQPSSGASV GAARPERCRR IDLEGQCEES
DAKAIEKTPF GSGKSGAEWS REGPHASGKR VEDQGDRRQA RKDAEASDCR TVSSQGSGED
GSETDEVVGG PLLREKDAAR GDASRNLERR DRGVGTQTDV EQAAAVARLS HPPAASSPSP
ELPGQVEPQA PGGRFRASPL SGVVSPLFLP TFAWASPAAL PPSSAPALPV LWDQNFREFS
GGFPLCLDSC DHAWLWRALQ RDTQLLQRLD VVDYSLLVLV EESGRVRRIS VALIDFFRPY
TWDKQVETIG KSLAYMTRGL LDQQPTVLSP PQYRLRFLHT MAAFFGPSHP TDLTGIFASL
LRLAPALTAR EGSADRDRRY PGEQGSAEGP RQSATSGNGG DTQERQARAE EADRCSASSL
PADNPEGSLA ASCNRCLYSV PPATSPPFSV CAASSSASPS QHFASAFDYP SETPTRRPSL
DARVPSVQSA AFSASTAPGK GGPAGREREE GEDAGERLGG EACRNAHAVP VRKAERRTEN
ATEERDARDT RIVHDVQSAT AAARASAFSA FLRLRIRDQQ RKDRGKRNYY
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