ID F0VIS8_NEOCL Unreviewed; 2951 AA.
AC F0VIS8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Ion channel protein {ECO:0000313|EMBL:CEL67630.1};
GN ORFNames=BN1204_034260 {ECO:0000313|EMBL:CEL67630.1}, NCLIV_034260
GN {ECO:0000313|EMBL:CBZ53639.1};
OS Neospora caninum (strain Liverpool).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Neospora.
OX NCBI_TaxID=572307 {ECO:0000313|EMBL:CBZ53639.1, ECO:0000313|Proteomes:UP000007494};
RN [1] {ECO:0000313|EMBL:CBZ53639.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ53639.1};
RA Aslett M.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBZ53639.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ53639.1};
RA Reid A.J., Sohal A., Harris D., Quail M., Sanders M., Berriman M.,
RA Wastling J.M., Pain A.;
RT "Comparative genomics and transcriptomics of Neospora caninum and
RT Toxoplasma gondii.";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000007494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|Proteomes:UP000007494};
RX PubMed=22457617; DOI=10.1371/journal.ppat.1002567;
RA Reid A.J., Vermont S.J., Cotton J.A., Harris D., Hill-Cawthorne G.A.,
RA Konen-Waisman S., Latham S.M., Mourier T., Norton R., Quail M.A.,
RA Sanders M., Shanmugam D., Sohal A., Wasmuth J.D., Brunk B., Grigg M.E.,
RA Howard J.C., Parkinson J., Roos D.S., Trees A.J., Berriman M., Pain A.,
RA Wastling J.M.;
RT "Comparative genomics of the apicomplexan parasites Toxoplasma gondii and
RT Neospora caninum: Coccidia differing in host range and transmission
RT strategy.";
RL PLoS Pathog. 8:e1002567-e1002567(2012).
RN [4] {ECO:0000313|EMBL:CEL67630.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CEL67630.1};
RX PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT Transcript Features.";
RL PLoS ONE 10:e0124473-e0124473(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FR823390; CBZ53639.1; -; Genomic_DNA.
DR EMBL; LN714483; CEL67630.1; -; Genomic_DNA.
DR RefSeq; XP_003883671.1; XM_003883622.1.
DR GeneID; 13443050; -.
DR VEuPathDB; ToxoDB:NCLIV_034260; -.
DR eggNOG; KOG3713; Eukaryota.
DR InParanoid; F0VIS8; -.
DR OrthoDB; 228442at2759; -.
DR Proteomes; UP000007494; Chromosome VIII.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR003929; K_chnl_BK_asu.
DR InterPro; IPR013099; K_chnl_dom.
DR InterPro; IPR047871; K_chnl_Slo-like.
DR PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR PANTHER; PTHR10027:SF10; SLOWPOKE 2, ISOFORM D; 1.
DR Pfam; PF03493; BK_channel_a; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000007494};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 179..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 213..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1033..1052
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1125..1146
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1158..1175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1182..1201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1133..1210
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 1382..1488
FT /note="Calcium-activated potassium channel BK alpha
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF03493"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 42..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 124..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 711..738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1618..1657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1701..1738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1979..2077
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2124..2167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2180..2220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2242..2268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2284..2410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2433..2464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2479..2526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2645..2714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..313
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..361
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..408
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..423
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..454
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1994..2008
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2153..2167
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2242..2260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2360..2374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2392..2406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2679..2694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2951 AA; 315111 MW; 94E23852C0A4DEE7 CRC64;
MEGPSGEPTR PPASAASLQA PAVRASVAGY SGATAFSDCV SQPDEFQSVP PFHSPPSGVD
TRRGSARSQP SLSPSGYSAG IPAPPGPPSS AVSSASPQDA SGGLPASGVG ESVSFVKRSK
SGYVPAPAVG GPGSGVDRDP LEPPPRPHAP QQSPFAVDID LFELPDRKKR GGRRRAVQLL
WTHGFFFLGR LLVFAFALFL IYCTIADLGR YRWLTLTVAV PIEVAMLVLC QLLLKLPSWK
RYFERMLTDK LLNFSHQIEQ QQIGPQHMQS TQLTGPRGSG TDYGDQGDDD AAHPAQPLGG
DEEARKRPEN GAISRFSFRR GVSRLDSRLA VDEEDELAEQ SSTSEADAGE RRPHGSRSHP
AESDTSSRLQ SLPDAAHDSG AEPRGREDGR GATSDGDRPE ERGSVVRKST QEDGNVSGEA
SEATRESSRW RRLFRPRASR PQQEAKDARL DSRRFSGRAG SAPPLETDRP RRSGTSGRLQ
AERARASPGG GKAPWNGDAS AQAGASDAAH APRERPTSTH RPGETSSTSP AGVGREARRN
ASGPRDRPQS PASRGGSAPE GHRADRCAQP DAGASPRHRP RSMTPGAYPP FYGYSPRTPH
CMAYRGAEGI RDPAYPVRFA SDDLSNLWIT YRHQGVPRGQ HRLSLAGAGP GISGPSRFLN
YYTQTRPGRQ RQARGPWGYE APLGGSGRYG AGYGGTHVKG VTSCVDLRTA TEPARRDQLP
RASRRNYAEG HAEERTDSDV RQFTRVADLF RLRSFSKSPG QASRPAADAL QKRSWKALRL
PPGFSGSKGR EDMQRVLERD GMDEDGATPG YPRLRRRSTL PWPRHYLYED QDPHSLFGLP
GGRGYSLGGA ETRLRHRRAG SLSRRHLDWT SRIRLLMLDE DDSLVDEQSL YEPEEVDPAG
ELDDEGRYAK GKAVPRTRRE RLAAWWRGRK ESCVLFFRCL VMLCDSVAGP AVGSSAFLLA
VLLRTMAWCA VWVWASTLMV REPQNKDLFA WEFDNLPQAY YFVESTFLWM VTFDYCAGLF
TAPRKLQFVL SPYSIVDLLT MPMTSFIVNC FVDDQRLGLA RPDPAWGDVA EYSAPSKRHA
QPHVGTHDQF PWLLLFGWLR FLRLVKTEHV LSRCFPYLSV VKLRILSIVV SWLMIVLTFA
GGMFVLEAPE PDINYTNVYD FCFYAIVTVM TVGYGDFVPR SAAGRTLAIV TIISTFAFLP
GEVQRLMEAL REPRTIVGSP PAPGDDYLCM VGPIQPRQLA VICREIARAF PGSVQAILVI
TPLPVSAYDD ICFFSLSVCI RGGVRGEPLP SNIRSYCSNA RAVFIFSNTR AYQTLRAGGD
PSGVPDPSWI EGVETREQEE DHMTLLRFMG VRTVCFPVRP INVQLIHDHR KALVKEMGAY
STLCINEVKM KLLGKSCADC PGFVSLIANW FTFWRASEEG TGIAWAASRA KPAASSSRPP
RKTDFHHYAD GAVYNIYRME FPECMLGVHY KLLTRLLYTH YEVFLIGIIA ITKEIWINPF
RYFIGEELVN GYTTWPFAGI VLAPSLETVV KLSTLRDLPV KVPRAPCFSG AAGSPSGYTR
GSAFPATALL EREGQTAKRM WTAARASVAE GVKQGRKATQ RAKASLGGMH HAGLFTTAPA
DNANARGGDP QAFGGDGALG PSRAGPAQSG GQGSLAGDMY PLPAVSSSVS GGFPGQASPG
VSPYFGSASC LASTYPGAAA AAPGSPGVGA SPPALPASPG GIGGASPSPA APVCAHHRRH
LGGGAGPCDD QALGAPASPF GFPASPYAPL RGPGTAVPAS GASDFSAASQ KPKAACVLCQ
TEAKSLSLDS AAVSQHAFGH SFAFSSVCDL HGNRRPAFGG ILQTHSVAEA RRTIFANPGN
PVILACGWPR GLRIFIKTLL ANGAYNVVIL APHCPATVGP SDFAAYATSC AYVRGSALST
TDLLRAGALL ARNCAVFSTL HVAWKGDLSA ARLDTQALLV RKTIQALFRA FPVMRQREPG
AAPAAGDAVE PYSRFSGDGD HDAFERQTGA ADRPTPGTLG AHASAAGPRG SLPPGAGDES
RLHGAAPRLG EGSDWAPTAS KAKATAGRLS RLDSEALPRR LASQAGAWGT GPRASGEWLR
GAPVSARDTQ ASDRATHVLQ AVAHHAESPD AGWEERESTG GPRCPVSEGS DGEVVEGESR
SPPTRTETLA KRKEVRIDVR PAAGARAESP PRRGPLHWPQ GPGREAGGGP RVGESATAAR
VSPRSELARY VAIPPMCSSP TFSPADSASL ADSPCSWRSC SRGESVHKAT RRLRLRMPRH
GFADYVEPED GESSSACSLP RSPHAPSSAG RGSRESRRPL VASLDPRDSE VAVTRFATDP
RHSAPSPALA GASADAGPLP SSPQAPSNVS GISLPVASGR EEFPASRSPS REPPSPGATE
RTSDQLRHQS AVQHELEQLL EDRSFQAQLR QPNLPAGSNL RSPGMAYAPA HAAPSPLGSP
TAPLDPAVAS SLGIRLPVGS PGSAGASPPG AVGPARPRPA GASGGPTGPP PASHAQAHGD
GASVPLASFP SAANPVALLP VAHSGSAAFE PSGAGAHAGA AEAAPPGAEL VAGANLREND
GRVWYLVPSD FVRGAPSLVA TPAGFAGHAM SPTAAETHLQ NGDAEERTQV GGAPRCWRIG
GVVQPAGAPE RAREGEKCHG TLPFPHPFEA PQSPDEASET AADLGQQRND DATFLQGEGD
TAGGPAERSG EGGWSARDAG ELLSFVDEKA RKEPGIFLDL KESSFLEYCD NSMVMNEAFV
YDRIDSYRRL WVSDKKEMTA AYLGSLLFAS GHACVEDMFY GLMAHTLPVS KYAVDASVID
YLVEDRKGCI DAQKRLGRKL TSYPCGPNSV SCAAATSTSP SSSPLGLEAV PPMFVGVPFK
RLFEHLIKLE KKIAIGIYRQ YRVATDYAGH RRPKKLVLCC PSPQLRLTAF DKVYVLRPCS
TEALRQPRAF L
//
