ID F0VKX6_NEOCL Unreviewed; 2209 AA.
AC F0VKX6;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 13-SEP-2023, entry version 45.
DE RecName: Full=Tyrosine-protein kinase ephrin type A/B receptor-like domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=NCLIV_051540 {ECO:0000313|EMBL:CBZ54727.1};
OS Neospora caninum (strain Liverpool).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Neospora.
OX NCBI_TaxID=572307 {ECO:0000313|EMBL:CBZ54727.1, ECO:0000313|Proteomes:UP000007494};
RN [1] {ECO:0000313|Proteomes:UP000007494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|Proteomes:UP000007494};
RX PubMed=22457617; DOI=10.1371/journal.ppat.1002567;
RA Reid A.J., Vermont S.J., Cotton J.A., Harris D., Hill-Cawthorne G.A.,
RA Konen-Waisman S., Latham S.M., Mourier T., Norton R., Quail M.A.,
RA Sanders M., Shanmugam D., Sohal A., Wasmuth J.D., Brunk B., Grigg M.E.,
RA Howard J.C., Parkinson J., Roos D.S., Trees A.J., Berriman M., Pain A.,
RA Wastling J.M.;
RT "Comparative genomics of the apicomplexan parasites Toxoplasma gondii and
RT Neospora caninum: Coccidia differing in host range and transmission
RT strategy.";
RL PLoS Pathog. 8:e1002567-e1002567(2012).
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DR EMBL; FR823391; CBZ54727.1; -; Genomic_DNA.
DR RefSeq; XP_003884757.1; XM_003884708.1.
DR GeneID; 13446432; -.
DR VEuPathDB; ToxoDB:NCLIV_051540; -.
DR eggNOG; ENOG502S7DK; Eukaryota.
DR InParanoid; F0VKX6; -.
DR OrthoDB; 204671at2759; -.
DR Proteomes; UP000007494; Chromosome X.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR SMART; SM01411; Ephrin_rec_like; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007494};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 401..421
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 459..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 773..794
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 827..849
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 883..902
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 922..944
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 956..976
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 988..1013
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 530..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1777..1826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1900..1923
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2020..2058
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..546
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..607
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 608..631
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 645..661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..705
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2043..2057
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2209 AA; 239353 MW; 703DB68EB598C65A CRC64;
MEEAKAEGRD RDRRSAPTVR TPFLCLASIV LVSAVALLFV REHAFFGLPR NSNKVANPPA
GNLSPRDAAS ARTTLTSLSS RSPSLSGASR LSVGPKFRPR RLASGLATSG TLCDGGKYWD
NRQAACADCP AGTFSFYGSV GIQRCMACPF GFYSSAGAAV CDACDANMSF KPALNAAGGV
SCEACEPLFE YCYRTSPTDD SDWWSWSMVC SSGAKGTEQA NGVRGMQVNE AGDAALGSES
FGSLSAAAAP LVARPSAQVA RPEGSEKGAS PTMFRGSARL FRSFTKQARQ GDQGSVEHPF
CETLRNANPA GLNFRLKCRK RGVCTGVVAS PCTEGNTGVL CDRCDNGYTL PLLEPTASSC
TKCSGGLMAF LGFMLLCLCF VAGLVVWLAR GNDATSFNRN IVIIRIFVVH MQLLNLLRFR
ASAEMDSVAK LWNVLVLTIP IESLVECLDT FTEWSGTTFT FVIVGLFFPI FNLICSLAVG
GVLRKLHVRK LKQEMTQSVT EDVYLNPALH AGTELTALAR EAEERREQIK ARVAKRAEDA
AQRRKAAEGG PVRPGAFVKK GKGKKVENAE GLPRAAMAAK DVQERRAKQL EAKRRKAEKK
KKPKRERGLE RRIGVQEDQE REAKEGEGDT AWKAQGLRQP LQAPDLSDSY YSSSFQSSEQ
VESGVDKKEF QPAAAHASAP VDGAAVARAR GDPNTKERDQ NEEPDDPAEG GGGAVPAAWL
AAGPGKMQAP DAPEAEVSED EEAELDAKKP KKPQPVPAMP TMHTADLYGY WKWVFAVFFV
LHYSCLVTIG TLLFKGIFCV TDDVIPGVSY EFLAADFSLQ CSSASTFTIS ATAGIVLWLV
LLPAGHFYFM SRRLGDDIWL TDQYSLFCSW PVYGFRSGYR ITYGLQVVAV ILVLVVTSTP
ISHGRLERSL EAPGGIVFSF SFLKIITSTQ IIICINIIGL YLIFLFIAHP YEPAKFVLSS
HLAVLSCAAA IALYIYTYYQ NIAPGTSVAS GIGIVAFLLQ IIFFLCAGVC ALVESGFVKQ
TRNRFAFVDE VLAAASNTIK HTGTYRALQG DGEEQDVQER WEALRMDRAS KEAQRNQQAR
HARLGVGDAA PGAEEIVVER AAILRLTSKK DHVALLDAVT ACNSVPRALA AFERLTFLDT
FPTMEKPEAR AALEKLGFDV EELDGGLKLF LKHRNAMMRV FSRFSVSSLS EAFACGWELG
LLRYSELDDV TLELASTKQK ADRLLQQARA EDIAHMGRRG AGLYREDVRE WNVLKAEACR
ITLQCLLLDL SDHHFHIARE LPRRRFLATG TDQDAEDIRV RRVVDEDATG SRAASEDADA
GAFLRLASLE EEGETAGFRA GLQLYEFAEA EPKRLRRKRL LEQTYALYRD FKLIFPNALP
CIDRAPEARA QERAKASSPA AGPGRDDPLG AVKSFQLHVL GHHISAEDGR DVFFRGNFRA
VAGPSGDLTG LDLSQNPRSV IVLDPPVALH ARYAIECWVL LPLPPPSASA SSVGIYRSLC
ADSDGDVICC LRQGPSRTAQ RRREREAAEG DYKDAVAEKK EAAANRQLHF GLFLFPERDE
EESVASDVAS NCGSDAADAR TSLAARGAQN VETGDLPGGD LGFFEAKAHA SEKARVARAD
KQLQAGWHHL VVSRCESGTS YYWDGECVGS ISALALPFAG FHDIAAIGNT RDGGHVCGAL
SDFAVFATHL DDEAAKLRYS YLQRHLVGKA TAGQGLPPAQ KRESGAADAG RYGLGTAAPG
ALAFDLLVDV YFIPASSRKT WALCAASPEQ MKAITYRRES SREQPRKAGA AGSSLKRCEA
SGKGGVALVS PGPSRGATER AHGGSTANGS CVALDPAVEV DRELVPVRAW TVFAWIYTPL
PQTEAAHVLV AGEADFHVCV LKDQRSVGVM YCAKRNARGE GTESSTEASD ASDDASVDSD
GCQREEYPSG FDIRDLAKGW HHLCVVANEA GQAFYADGTL RGYLPKSTWE DIRFLGNAAT
GNKPWGTFAQ VSIYGKYFGA AEVASEYAKY RVDFPDPVGS RRLASKGPGD ETLTAGDSSQ
GENEEDGENR VDSFSQPDDG RAYKGYMSFQ ICSDGESVVL LPQVAAQKHD IRVFHIDEFA
VGVSGQHVAF DCVRSLALER QRRQVESGGG IRIHPAVSCK RAWTIVGWIQ TPIENTGMFH
ALVGGKDGDA HVAVDRDGET LARTYAEHQD LIRSGKFDPV SSGAQDHPE
//
