ID F0VLC8_NEOCL Unreviewed; 1652 AA.
AC F0VLC8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE RecName: Full=indole-3-glycerol-phosphate synthase {ECO:0000256|ARBA:ARBA00012362};
DE EC=4.1.1.48 {ECO:0000256|ARBA:ARBA00012362};
GN ORFNames=BN1204_053050 {ECO:0000313|EMBL:CEL69602.1}, NCLIV_053050
GN {ECO:0000313|EMBL:CBZ54880.1};
OS Neospora caninum (strain Liverpool).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Neospora.
OX NCBI_TaxID=572307 {ECO:0000313|EMBL:CBZ54880.1, ECO:0000313|Proteomes:UP000007494};
RN [1] {ECO:0000313|EMBL:CBZ54880.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ54880.1};
RA Aslett M.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBZ54880.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ54880.1};
RA Reid A.J., Sohal A., Harris D., Quail M., Sanders M., Berriman M.,
RA Wastling J.M., Pain A.;
RT "Comparative genomics and transcriptomics of Neospora caninum and
RT Toxoplasma gondii.";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000007494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|Proteomes:UP000007494};
RX PubMed=22457617; DOI=10.1371/journal.ppat.1002567;
RA Reid A.J., Vermont S.J., Cotton J.A., Harris D., Hill-Cawthorne G.A.,
RA Konen-Waisman S., Latham S.M., Mourier T., Norton R., Quail M.A.,
RA Sanders M., Shanmugam D., Sohal A., Wasmuth J.D., Brunk B., Grigg M.E.,
RA Howard J.C., Parkinson J., Roos D.S., Trees A.J., Berriman M., Pain A.,
RA Wastling J.M.;
RT "Comparative genomics of the apicomplexan parasites Toxoplasma gondii and
RT Neospora caninum: Coccidia differing in host range and transmission
RT strategy.";
RL PLoS Pathog. 8:e1002567-e1002567(2012).
RN [4] {ECO:0000313|EMBL:CEL69602.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CEL69602.1};
RX PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT Transcript Features.";
RL PLoS ONE 10:e0124473-e0124473(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001633};
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 4/5. {ECO:0000256|ARBA:ARBA00004696}.
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DR EMBL; FR823391; CBZ54880.1; -; Genomic_DNA.
DR EMBL; LN714485; CEL69602.1; -; Genomic_DNA.
DR RefSeq; XP_003884908.1; XM_003884859.1.
DR GeneID; 13446584; -.
DR VEuPathDB; ToxoDB:NCLIV_053050; -.
DR eggNOG; KOG4201; Eukaryota.
DR InParanoid; F0VLC8; -.
DR OrthoDB; 230791at2759; -.
DR UniPathway; UPA00035; UER00043.
DR Proteomes; UP000007494; Chromosome X.
DR GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR PANTHER; PTHR22854:SF2; INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE; 1.
DR PANTHER; PTHR22854; TRYPTOPHAN BIOSYNTHESIS PROTEIN; 1.
DR Pfam; PF00218; IGPS; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Reference proteome {ECO:0000313|Proteomes:UP000007494};
KW Signal {ECO:0000256|SAM:SignalP};
KW Tryptophan biosynthesis {ECO:0000256|ARBA:ARBA00022822}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..1652
FT /note="indole-3-glycerol-phosphate synthase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007655255"
FT DOMAIN 261..509
FT /note="Indole-3-glycerol phosphate synthase"
FT /evidence="ECO:0000259|Pfam:PF00218"
FT REGION 138..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 259..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 563..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1064..1085
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1098..1138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1174..1501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1566..1600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 563..587
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..646
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..687
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 816..830
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1109..1127
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1174..1207
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1253..1271
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1346..1362
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1445..1474
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1475..1501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1652 AA; 176356 MW; 6A40AFF70057D26B CRC64;
MLAPARLLSR VPLLFFLLST AHHFAWRILA QRGEGIAFQT ARAATAARPS FLRCPQLQRC
SSSRVFSPGP SYLAVVSPAS ASTLSLPSLA SFSSLRAPSR PRLPVERLPA PPANAPQALL
CFLPGCTLHK SFLPLLPNVH GRNRQQSPND KSQERPASSP GASRLRASVR DRRLPSRALD
QLQRLLEAKQ YEVKLLVEKH GSLLDPLALR QAYVHHTLNS KLTERMRIQT HVRERDEKIR
AMHAARWQER DREAVLGKDA REEGQEPKCE QALQSHSHRV GGEHPRYDLQ EVLQEPETPH
RLSVACDLKR RSCTNLAVDP RRLSYRNPGD VAVDCASAGA DVILVNTNKE GWGGSYEDLE
ATTKALRNAY SWSERPAVVM KDIIIHPIQI AQAVEAKADG VYLHFCVAGK DLEDLLFACS
TMGTQALVEV HSEAEAQQAE DAGATLLVVN QWDRYTGRLI PEHALRVRSV CSPEVIVLAS
GGLTSTAQAT KCAKSGFDGV VLGQALTRPG ALDFIKELKA WQGAPRELVH LFAPDPRGAA
AAARGLEEAA AAIEAEDAAL KAQREARRAA RPASRGPDSE TLPSEKREAL EQAALTSAHS
KQFPRPEEAA LDAESEFPGD EGDLDVAEKV FEEAKRGWKP ETHAEPAETG GRQCSASDSV
AGRPARDSGK ARKEATDRGH ARTRDRLSGG LSPDSTVPGE ERSEARGGQS RATPSDDFTE
RVLRQSGPDF QPQPAESLFG PRAVPRRNGD ASQAPAHPSV NASSGSRDSG RSPSPASRGA
YPAPPAGIVD VSGEQDEEPS QRLGQFHAFS TLRSSDASEG RDRRGDPPPV RIPEGTDCAP
NEEQLLRACT RELLGQIARE QHVKRMADEE HRDLQLAMFR QYQRLARASP ADDQKARTGG
AGPLFVPPLA LQDTLQTDPH FRSPGPEDAL DPLALGPQDA DSIAEPFKEA FPNDPARAAA
ACTAAAAAAV ADPSGFAAVA RDHLQKAAER GAYTLADSND PAAALSAAAP TFAAASATAA
LTAAVARGER DAQAAAKSAA AALRGAHPPS PKALAALAAA AVQERKARGD RPDQWGAPFG
PTDEQARVVD AEPQLLGASL APRGAAGRQG EEARSRESCE SRDPTARREI GMVPFGGPDE
EAELFDEAEL ERIGRLFFTE EELDGFLREL RAKKATRQSA RRGGEEEGVH GRAEKREDVH
SRRQGFHTAQ RPDGGGEEAT QKGTAVDTAA GAGVRTGSGG SLPMCLGKPP ETENSREGQD
ARADKEGTGT AEARTDGNGV PRRVQTETAG GAGAEASVEE RVADPARASE PSESSSESRP
VRARPSKAAA SWQAEKVSFS TQEWFARANR RKKEDHELVQ HVRQQTQRAA DQPAGKRDGS
PETDADSAPD SVSGARAETS SEAGASFRDG GRETFSRFGR HAPGPSLTTP MDQMEAFLPF
FQGRGSHHHL EDPPEVQERM QQEAFLEELK RRESTGGLTS ATLTGNPADS PLGDPSRTGQ
QAYELLEAQQ KRLQAERRQR PPAASLRAEA VAAAAAAAAA ALADGAPPQA AVQAVSRAAG
AATVGSAVDL SSRDREKPAN GCRQSTAGET EESVQRADAA PRAAVQGAML GGERGAYAAL
WGTSSQGAGG FFESYVDELA QSGGLQVEPS ED
//
