ID F0VLG6_NEOCL Unreviewed; 1595 AA.
AC F0VLG6;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Serine/threonine protein phosphatase, put ative {ECO:0000313|EMBL:CEL68793.1};
GN ORFNames=BN1204_045270 {ECO:0000313|EMBL:CEL68793.1}, NCLIV_045270
GN {ECO:0000313|EMBL:CBZ54094.1};
OS Neospora caninum (strain Liverpool).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Neospora.
OX NCBI_TaxID=572307 {ECO:0000313|EMBL:CBZ54094.1, ECO:0000313|Proteomes:UP000007494};
RN [1] {ECO:0000313|EMBL:CBZ54094.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ54094.1};
RA Aslett M.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBZ54094.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ54094.1};
RA Reid A.J., Sohal A., Harris D., Quail M., Sanders M., Berriman M.,
RA Wastling J.M., Pain A.;
RT "Comparative genomics and transcriptomics of Neospora caninum and
RT Toxoplasma gondii.";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000007494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|Proteomes:UP000007494};
RX PubMed=22457617; DOI=10.1371/journal.ppat.1002567;
RA Reid A.J., Vermont S.J., Cotton J.A., Harris D., Hill-Cawthorne G.A.,
RA Konen-Waisman S., Latham S.M., Mourier T., Norton R., Quail M.A.,
RA Sanders M., Shanmugam D., Sohal A., Wasmuth J.D., Brunk B., Grigg M.E.,
RA Howard J.C., Parkinson J., Roos D.S., Trees A.J., Berriman M., Pain A.,
RA Wastling J.M.;
RT "Comparative genomics of the apicomplexan parasites Toxoplasma gondii and
RT Neospora caninum: Coccidia differing in host range and transmission
RT strategy.";
RL PLoS Pathog. 8:e1002567-e1002567(2012).
RN [4] {ECO:0000313|EMBL:CEL68793.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CEL68793.1};
RX PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT Transcript Features.";
RL PLoS ONE 10:e0124473-e0124473(2015).
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DR EMBL; FR823391; CBZ54094.1; -; Genomic_DNA.
DR EMBL; LN714485; CEL68793.1; -; Genomic_DNA.
DR RefSeq; XP_003884125.1; XM_003884076.1.
DR GeneID; 13442074; -.
DR VEuPathDB; ToxoDB:NCLIV_045270; -.
DR eggNOG; KOG2679; Eukaryota.
DR InParanoid; F0VLG6; -.
DR OrthoDB; 205029at2759; -.
DR Proteomes; UP000007494; Chromosome X.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR PANTHER; PTHR10161; TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5; 1.
DR PANTHER; PTHR10161:SF14; TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5; 1.
DR Pfam; PF00149; Metallophos; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000007494}.
FT DOMAIN 359..582
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
FT REGION 110..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 917..947
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1276..1369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1532..1595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1058..1085
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 111..136
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1285..1342
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1532..1569
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1570..1595
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1595 AA; 183141 MW; C58E3967EFC4F5EC CRC64;
MSFLSAVGVA ATPLSGKRPG LISRRLDALV TKSIKKLLTW QPVERPVPSL NLDEVVFVAG
RHTAALSASF HTTLEDVLIL FFRWFDDTKT TRWARQGLIT MESLKRQHTR YGSQMAKDYT
KKQEEPEEDE EKKKQKVQPV KVYAGLGACQ RRNRHWIFDG NTFHRRGGEA FHIPDELTEN
DVNFMRGLPF SVIRVAQGIF ASEPPASVHR LERELKIRGV TTIEKLLSRT NFFDLFVLFD
VFDETLSQID VLREYHKNWQ KYKSGKFSPP QIPLGEWKEK RTMEELLLDD NYAETDFPKC
TTLKCFMQWT WRKTPEKTIE VSKKNVNALK LLLVGSAGRG TSYTPLSERK KMSFLKKAGD
FQDLEHTVDA LKDWHQREKA DAVLGLGDML GLPGATTVRD ERFQKRWHDI FVKDAGLDLP
WLMTLGDADS VLSPSSQVRY HYSVQHKNWH LPNDYYTVNF KFGANLTLAN GMFEETAFNA
TVLAINTWDL FVGNPIANNM ASWTNKLWWL SEQLYKATQK NSSWIIVMGH HPLLSTGPEG
EQARLQNIDD VYKNRRSRGL ESFLINTLFM HYQVDAYVSG HDLFMDFNSI TDVDRNVTVS
FITSGATARL FHKNVGRGWA GRLRGALYPL LCWGGRKVFF GFHPGGCKPL NKDQQHPDQF
FVQSQSGNYK VNIEERVTQA TGFAAMKLTK DYMLLDFINA RTKKSAVHKV YRRTNREGRE
IKFLDPFADG RLRYEELLLD REAFEAENAE LIEKEIAFAQ KCPVLAERLK FHVTEMNELA
GRYIELTQQK EVYETMTDTM RDLMATLGTN VQRKISEILS TMYVISADHA RLEKRYKEML
ELKEKMPEKE DPRFKDLFEL EKQYVETRKL RRKTFDALQS DSSSAGVEDE KNLRKYIMTM
KLLRKQMDDL EREMKQFPDL ETKKAAAAKK AQKESEQRAK KPKKTPAIKP LDTSILARIR
RKELQLRRHH AVLEGLARYP QSELKKMRAE INILKRQEAS VRQELARLHM IRKRSVQPMR
PSDQWEKFQV KEELETKLRQ INAYMHDVEL LPPAKRHSQS VQDEFEAIET QRAALEKELT
DVVDELADRK MTPLQSEFLA KSAELKRNEL VLEQRKLLSP EELAVPQIQK ALQAAADKQL
TLHMEVEALQ DKVRQELNAI EDAWEQEMSA KGYNVHDLSE DVVVGPEVEQ LSESEAQMVI
DSGKVDSAAN AANELDRAEE TLAAVEEALQ TADTVTGDEK EQLEAMLGPV EDLPAKEERM
RERVAALRKR LERETNMLEN LVPTEVPEEG KKQEGVEESP GADVEEAEAS KTETKKEEDE
LSSPAGDSKP LETDDAEDRA RVADGGIAGN SAAQTPDADE ELSPGATSPR RLASVLELFK
TKRDPSPFKK IEKVDVGPTD ACMQVPMLEA TVQRRLKPQS EEEVKEKCVH RLANQAYRQQ
LRYIHNGMFF SQGPQGLTPT LYDDPSVHVA RAWSEFFGYT HSSRFKSIMK DIRHGLQFVH
ETYKTYSFAE AMQMELLEAI RRREEELELP LDQDIEVRDN DVDMDVLAER EAPKTPEEDK
SPKEEKEEQS EEAEPGEEEP GTDIPIDEID TSYED
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