ID F0VRE1_NEOCL Unreviewed; 1941 AA.
AC F0VRE1;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Myosin, related {ECO:0000313|EMBL:CBZ56289.1};
GN ORFNames=NCLIV_067140 {ECO:0000313|EMBL:CBZ56289.1};
OS Neospora caninum (strain Liverpool).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Neospora.
OX NCBI_TaxID=572307 {ECO:0000313|EMBL:CBZ56289.1, ECO:0000313|Proteomes:UP000007494};
RN [1] {ECO:0000313|Proteomes:UP000007494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|Proteomes:UP000007494};
RX PubMed=22457617; DOI=10.1371/journal.ppat.1002567;
RA Reid A.J., Vermont S.J., Cotton J.A., Harris D., Hill-Cawthorne G.A.,
RA Konen-Waisman S., Latham S.M., Mourier T., Norton R., Quail M.A.,
RA Sanders M., Shanmugam D., Sohal A., Wasmuth J.D., Brunk B., Grigg M.E.,
RA Howard J.C., Parkinson J., Roos D.S., Trees A.J., Berriman M., Pain A.,
RA Wastling J.M.;
RT "Comparative genomics of the apicomplexan parasites Toxoplasma gondii and
RT Neospora caninum: Coccidia differing in host range and transmission
RT strategy.";
RL PLoS Pathog. 8:e1002567-e1002567(2012).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; FR823393; CBZ56289.1; -; Genomic_DNA.
DR RefSeq; XP_003886314.1; XM_003886265.1.
DR GeneID; 13445512; -.
DR VEuPathDB; ToxoDB:NCLIV_067140; -.
DR eggNOG; KOG0160; Eukaryota.
DR eggNOG; KOG0266; Eukaryota.
DR InParanoid; F0VRE1; -.
DR OrthoDB; 276000at2759; -.
DR Proteomes; UP000007494; Chromosome XII.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd14888; MYSc_Myo27; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF706; MYOSIN-11; 1.
DR Pfam; PF00063; Myosin_head; 2.
DR Pfam; PF00400; WD40; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 5.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50096; IQ; 4.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW Reference proteome {ECO:0000313|Proteomes:UP000007494};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 86..815
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REPEAT 1660..1701
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..692
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1042..1083
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1155..1196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1454..1508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1525..1556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1042..1080
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1155..1176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1491..1508
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 166..173
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1941 AA; 215037 MW; 4CE0F0134D5A3629 CRC64;
MTASSLDGAS PTGGGDQGDE EVRCAVGTKI YVSDPADVWK TAEVVKIQED GSLTARVDAD
NELVHLRKGD LWYLCNTDVW NTTGLSAPTD LTMLTHLHEA AVLDSLNLRF DIDEIYTFTG
PILIAVNPFK QIAGLYDMKP HVFASSSAAY EGMCNEKQSQ TILISGESGA GKTESTKFVM
KFLACAGSDD LERRSQVEAQ VLESNPLLEA FGNARTLRND NSSRFGKFIE LQFQTNKTKR
VSGNRGRLCG ARIQTYLLEK VRVCDQQEGE RNYHIFYQLC AAAEAAAQKG GIYYFPSPKF
RKAADAKPQE MDMSLFEPRD KFKYLTKSSC HALQGVDDCE EFDSTVFAMQ TVGISPEEQM
NIFSVVGAVL CLGNVSFETP KGNSEGSQVA PSCAEYVSKA CRLLGVESDA LQEAMCYRTI
KTMHESYRKP LKTDEAWEMK DALCRALYGC LFLQVVARTN QSIGYLTEVK SPDDVLLFCG
VLDIFGFECF AFNSFEQLCI NFTNERLQNF FNTFVFKCEE ELYRAEGIQW NPLDFPDNAD
CVALLQDKPL GLFSMLDEEC MVPAGKDRGF NNKVCQKHTG HKRFGVIKTK PNCFVVHHFA
GSVEYCSDGF LEKNKDQLSL DLQEAIKASS IAFVSHLFTA FLNRGASEDG ASVGKKRKFV
TVSSEFREQL GSLMDTVNKT APHFIRCIKP NPQNLPDLFD RVTVNEQLRY GGVLQAVQVS
RAGYPVRLSH RDCFFDYKAL ADKAVLEKLC MQSEGTVSSE TWRERAQALL LHLDAKLNLD
RKKKDAPSHD KTWAVGKSLC FFKNEAYEVL SASLMSVRVQ AATAIQARYK CFVQRRFFLM
YRQTVVFLQS HVRMFLCKLE AWRRRQDRAA KRIETFLRGA VARLRYLRTL KQIKTIQAAW
RGKQTRSKLR DLQLHEAAGK IQATWKMHRQ RASYRDLRKA ATLAQLKWKR ILARRMLRRL
REEAREVSGL LKKAQDLQRD LGEERSKRSE VESHVLQLQA KNEELLKEIQ RLHKELDRAK
EEVASLQASN EDFASQVKQL KESLTAGSST PSTPQMTPGT QKRRLSNHAD AQQSQGDRLS
TQTDEELKAL RQELEKREAE AQLQQSEHET LIAKLQASLK EAESALEQEK TQRSEAEARY
KLVLEDSSAS STHFRLSSAG AAKQQPGSSL ASGEAGGVSS TLLREKRNKV PDGDGALAAT
KTLSPLPSVA LASEHWECVL HDQRWIDLLL LGPAGVGKTG LLEQFLIKLG DEVHLEQLRV
SRKMEDQAPF SKLPQHYELV YPRDSEDAPT RGAKPRDDEL TRVNVLDFPG PSRTKQNPAL
RVKQAFVVAV VYDPTRPETC DEALQVLTNV VLPCRPKVAA QDGLAACVSG RVYLVENGWR
VAAREGTVQV DTAAIRDKGT STAGLRCHYR ELVHLESLVD EIVPLMAEWR GMLQQQRLAM
LQHHARLQPG SAAGLSPFAL PRPPAQASRG ASLSFSNAAH AAGSGLRENG AEKSPSVSGS
ASGTHRQGSL SANLFDSIRS FLSQSSMRPG PGSALASGAK QSVDSKLLRP SMKPGGSAML
KKLKSRNMDA HSVVPVQELQ DSDSAITCVV FGKEKDNRDY ILLAAASKDG SVVIYRCYRL
EAERQMFDQE QVSLLVAPAS KPPGDNREHF GPSVSVHSRL VGHSRAVTCL FFSLLEDQLV
TTSIDKSVRF WHVDTGDMLK VFTDSSPALA AAFLPFNPTA FVASNSNSIL RLVCATSGRV
IQKLKVESEV RALKFDDTGL FCFAGTKAGA VHVLEASDTI NIRFKFKTTL GKGAVTCITF
VPSTGPGQYP RLLINCCDSS VAIVECIYGP PPGVLTNLLV RHRVRIAHSL LPLRCWFSNF
GGGWLITGSE DKDVYCFSLQ QGANFKAISL KHHQAPILAV ATNLQDTLLV SADSMGKLVL
WRSLDFSGAA DASAGARGRA V
//
