ID F0VRS9_NEOCL Unreviewed; 915 AA.
AC F0VRS9;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Calcium-binding mitochondrial carrier protein SCaMC-3 {ECO:0000313|EMBL:CEL71186.1};
GN ORFNames=BN1204_068510 {ECO:0000313|EMBL:CEL71186.1}, NCLIV_068510
GN {ECO:0000313|EMBL:CBZ56427.1};
OS Neospora caninum (strain Liverpool).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Neospora.
OX NCBI_TaxID=572307 {ECO:0000313|EMBL:CBZ56427.1, ECO:0000313|Proteomes:UP000007494};
RN [1] {ECO:0000313|EMBL:CBZ56427.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ56427.1};
RA Aslett M.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBZ56427.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ56427.1};
RA Reid A.J., Sohal A., Harris D., Quail M., Sanders M., Berriman M.,
RA Wastling J.M., Pain A.;
RT "Comparative genomics and transcriptomics of Neospora caninum and
RT Toxoplasma gondii.";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000007494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|Proteomes:UP000007494};
RX PubMed=22457617; DOI=10.1371/journal.ppat.1002567;
RA Reid A.J., Vermont S.J., Cotton J.A., Harris D., Hill-Cawthorne G.A.,
RA Konen-Waisman S., Latham S.M., Mourier T., Norton R., Quail M.A.,
RA Sanders M., Shanmugam D., Sohal A., Wasmuth J.D., Brunk B., Grigg M.E.,
RA Howard J.C., Parkinson J., Roos D.S., Trees A.J., Berriman M., Pain A.,
RA Wastling J.M.;
RT "Comparative genomics of the apicomplexan parasites Toxoplasma gondii and
RT Neospora caninum: Coccidia differing in host range and transmission
RT strategy.";
RL PLoS Pathog. 8:e1002567-e1002567(2012).
RN [4] {ECO:0000313|EMBL:CEL71186.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CEL71186.1};
RX PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT Transcript Features.";
RL PLoS ONE 10:e0124473-e0124473(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375}.
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DR EMBL; FR823393; CBZ56427.1; -; Genomic_DNA.
DR EMBL; LN714487; CEL71186.1; -; Genomic_DNA.
DR RefSeq; XP_003886452.1; XM_003886403.1.
DR AlphaFoldDB; F0VRS9; -.
DR GeneID; 13445649; -.
DR VEuPathDB; ToxoDB:NCLIV_068510; -.
DR eggNOG; KOG0760; Eukaryota.
DR InParanoid; F0VRS9; -.
DR OrthoDB; 5481380at2759; -.
DR Proteomes; UP000007494; Chromosome XII.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR GO; GO:0048250; P:iron import into the mitochondrion; IEA:UniProt.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 3.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR45758:SF4; MITOFERRIN-1; 1.
DR PANTHER; PTHR45758; MITOFERRIN-1-RELATED; 1.
DR Pfam; PF00153; Mito_carr; 5.
DR SUPFAM; SSF103506; Mitochondrial carrier; 2.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000007494};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT REPEAT 491..586
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 683..765
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 781..904
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 130..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 230..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 602..619
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 915 AA; 96785 MW; F608E933494A103D CRC64;
MQEGGREYGA PLGPRDPPTP DRIANIARGL GSEGAANGER RGETGASGAA HTTSCGRGAG
DAAFRSNAQE THLDWEEWQG DWPLPMHAAA GSVAGLMEHL AVYPIDTIKT RAQALCMAPP
HLSEACTDQT RDALKRQPRS APCARNARAG EASATAARGS SSAPQQITVS KPPSGDGLRS
LWSGGSEGGR LAAGHAAEAR MTLQMAHSPL QGFCPLRQIA VPPCPISQGP YPGPSPLSSL
AYSSPKKNST PGDMGMRLRS SSSFARPPSF DKSTAGSRLG PRSSGEKSGK ALASGTWRPV
SQRAVLPPST AHLNFSVLSA DFSRARARQR SYPGRLAQAV AEREFHAERG RASWGHRHGR
LALPACEAVG QRLARADASR LLGRPLASAV ERVHSAWLVR NFAGGASRVS RPERVPVVSS
ASGLVGSRLS GHSLGSAVSL VRRLPLFSLP PVSASASLPP SPLGDGGPAT RGGLPRAVAS
LAGSGTGDLW RRHVATLVGF SPPSGEGTGC ASPGQTTARR AHATFAPYTE EEFRIARGRF
SVFSAAKSLY AEGGIPRFYR GATAVASGCI PAHAFYFLSY ERMKQFFLER KDRPRSSTAE
APGAVPVSSS PPSSLGASKN QERRDTDQGS EASATEFHDG TTRGRWGQEE AAPGSGWPDG
WIAVGEGPPG REGGPVGAEG AQLSPVESFV CGGVATITHD AILTPMDVIK QRLQLGCYRS
PLDCLRTVLQ DEGGMALCRS LPATVLLNVP FGATLVCVNE WMKQTVLPPD SHTDQRSNLH
LYFLCAAVSG GVAGLISNPL DVIKTRLQTQ DCYRQQQEAL IRQAAARTRG LEGPGGVQRA
RPPCARTAFL PRVTKKYSSL HSAVRTIFRE EGFRGFWKGT STRIALSTPA TGICWGTYET
VKFLWKRFCV AEGNM
//
