ID   F0W477_9STRA            Unreviewed;       754 AA.
AC   F0W477;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
GN   Name=AlNc14C16G1752 {ECO:0000313|EMBL:CCA15892.1};
GN   Synonyms=AlNc14C430G11580 {ECO:0000313|EMBL:CCA26913.1};
GN   ORFNames=ALNC14_020350 {ECO:0000313|EMBL:CCA15892.1}, ALNC14_130570
GN   {ECO:0000313|EMBL:CCA26913.1};
OS   Albugo laibachii Nc14.
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Albuginales; Albuginaceae; Albugo.
OX   NCBI_TaxID=890382 {ECO:0000313|EMBL:CCA15892.1};
RN   [1] {ECO:0000313|EMBL:CCA15892.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=21750662; DOI=10.1371/journal.pbio.1001094;
RA   Kemen E., Gardiner A., Schultz-Larsen T., Kemen A.C., Balmuth A.L.,
RA   Robert-Seilaniantz A., Bailey K., Holub E., Studholme D.J., Maclean D.,
RA   Jones J.D.;
RT   "Gene gain and loss during evolution of obligate parasitism in the white
RT   rust pathogen of Arabidopsis thaliana.";
RL   PLoS Biol. 9:e1001094-e1001094(2011).
RN   [2] {ECO:0000313|EMBL:CCA15892.1}
RP   NUCLEOTIDE SEQUENCE.
RA   MacLean D.;
RL   Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the nicastrin family.
CC       {ECO:0000256|ARBA:ARBA00007717}.
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DR   EMBL; FR824061; CCA15892.1; -; Genomic_DNA.
DR   EMBL; FR824473; CCA26913.1; -; Genomic_DNA.
DR   AlphaFoldDB; F0W477; -.
DR   EnsemblProtists; CCA15892; CCA15892; ALNC14_020350.
DR   EnsemblProtists; CCA26913; CCA26913; ALNC14_130570.
DR   HOGENOM; CLU_361508_0_0_1; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0016485; P:protein processing; IEA:InterPro.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR041084; Ncstrn_small.
DR   InterPro; IPR008710; Nicastrin.
DR   PANTHER; PTHR21092; NICASTRIN; 1.
DR   PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR   Pfam; PF18266; Ncstrn_small; 1.
DR   Pfam; PF05450; Nicastrin; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..754
FT                   /note="Nicastrin"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5010831130"
FT   TRANSMEM        721..742
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          44..195
FT                   /note="Nicastrin small lobe"
FT                   /evidence="ECO:0000259|Pfam:PF18266"
SQ   SEQUENCE   754 AA;  83441 MW;  4749AA24B840E278 CRC64;
     MFRRPKHSFS VPFLLLLRHF EFVFSSAINA GTPEQLIASG GEFVRSFHSK GDVGSRSRSR
     QDVAPLYLIE TLRDLDNVQS LSHQVTLLLP EVLISKVPSS LHPKIAGIFL IPANGNTSLD
     SKTPQANGTV DQNLNPFWQS RQQYNPTGSN ILEQAFPFSV VLLSRATVGR EFLERARQNR
     EKEASNSYPE YRAYMNYYFG PSKMNSAQCL EFRDINGEKA PQCDPIGGQS VWGYRYTKYG
     NLSESLRHSN GEWIMVMAGM DAKSLSQVLA PGANTAVSGI VALLAAAHAL QTVPDDELVR
     PIVFGAFQGE KYGFVGSRRF LKDIQEFQSA ARKHGTNMYA GCRAPAFNSH SILGDDICTD
     PIHFNMEFAH LNLSKLTHAI AIDQVGVLST GRKQYYVHAN PLSAEPTERK ARSLFDIIKD
     CPASEPGRVA KSSVNNSLPP SPLLSFLNEK EFGRAGLTSV VFAGYDDQFV NGTLYNTHHD
     ILSAIDPNAV ATAAEIIAQS LFVLASTNGS EASVNSTRLK AIKVDSILVQ DLLDCIATDW
     SCDLIAQTSE PFVSTMIEYL DLTATAEPSY QQPVTLQTGS IDLNRQSLLM TANGRKYLTS
     LGQGLWNNET YRTRIFPNAY EVFIRSFLAS TLSPTKFSED AGTDKKHCSR TQTCNDPANE
     CIYPGRCRRR VAFFHDARSP GLDRTDTLGV YSIIDKNDPI WTEPHWDVDI GSYVFPDPGP
     WIGWVAMACG LSVTVVSGFL SFRMLQRLKK SKLL
//