ID F0XE00_GROCL Unreviewed; 970 AA.
AC F0XE00;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Flavin-dependent halogenase O-methyltransferase bifunctional protein {ECO:0000313|EMBL:EFX04254.1};
GN ORFNames=CMQ_1182 {ECO:0000313|EMBL:EFX04254.1};
OS Grosmannia clavigera (strain kw1407 / UAMH 11150) (Blue stain fungus)
OS (Graphiocladiella clavigera).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Leptographium.
OX NCBI_TaxID=655863 {ECO:0000313|Proteomes:UP000007796};
RN [1] {ECO:0000313|EMBL:EFX04254.1, ECO:0000313|Proteomes:UP000007796}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=kw1407 / UAMH 11150 {ECO:0000313|Proteomes:UP000007796};
RX PubMed=21262841; DOI=10.1073/pnas.1011289108;
RA DiGuistini S., Wang Y., Liao N.Y., Taylor G., Tanguay P., Feau N.,
RA Henrissat B., Chan S.K., Hesse-Orce U., Alamouti S.M., Tsui C.K.M.,
RA Docking R.T., Levasseur A., Haridas S., Robertson G., Birol I., Holt R.A.,
RA Marra M.A., Hamelin R.C., Hirst M., Jones S.J.M., Bohlmann J., Breuil C.;
RT "Genome and transcriptome analyses of the mountain pine beetle-fungal
RT symbiont Grosmannia clavigera, a lodgepole pine pathogen.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:2504-2509(2011).
CC -!- SIMILARITY: Belongs to the flavin-dependent halogenase family.
CC {ECO:0000256|ARBA:ARBA00005706}.
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DR EMBL; GL629765; EFX04254.1; -; Genomic_DNA.
DR RefSeq; XP_014173736.1; XM_014318261.1.
DR AlphaFoldDB; F0XE00; -.
DR STRING; 655863.F0XE00; -.
DR GeneID; 25974032; -.
DR eggNOG; KOG3178; Eukaryota.
DR HOGENOM; CLU_305659_0_0_1; -.
DR InParanoid; F0XE00; -.
DR OrthoDB; 1599601at2759; -.
DR Proteomes; UP000007796; Unassembled WGS sequence.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR016461; COMT-like.
DR InterPro; IPR002938; FAD-bd.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR001077; O_MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR43747:SF1; FAD-BINDING DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR Pfam; PF01494; FAD_binding_3; 1.
DR Pfam; PF00891; Methyltransf_2; 1.
DR PRINTS; PR00420; RNGMNOXGNASE.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51683; SAM_OMT_II; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EFX04254.1};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000007796};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000313|EMBL:EFX04254.1}.
FT DOMAIN 8..364
FT /note="FAD-binding"
FT /evidence="ECO:0000259|Pfam:PF01494"
FT DOMAIN 807..948
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
FT REGION 555..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..587
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 970 AA; 105819 MW; EB6D1BF228E32225 CRC64;
MASVPQSCTV LVVGGGPGGS YASAALALEG IDVVLLEAEV FPRYHIGESM LPSMRHFLKF
IGAYEKWDAH GFNIKKGGAF RLNWSRPETY TDFIAAGGPG GYAWNVIRSE ADDLLFKHAA
DCGAKTFDGT KVTSIEFAPQ DQVGEAGANT VGRPMSATWS RKNGSSGTIT FDYLVDASGR
AGMVSTKYLK NRSFNQGLKN IASWGYWKGG GVHGVGTHKE GAPYFEALKD ASGWVWFIPL
HNGTHSVGIV QNQEMAIQKK RQMAEPSSLG FYKEVLELVP GIKELLANAE LVSEIKSASD
WSYSASSYAL PGVRIVGDAG AFIDPFFSSG VHLALSGALS AAATIAAAIR GDCDEETASS
WHDKKTAESY TRFLVVVSSA LKQIRSSDQP VLHDFDEESF EKAFELFRPV IQGQVDADTK
GGLTQAEISK TLEFCFKAFA HVSFDEKEAL INKLKELGLD GDVHDENNRK ALDELEKELT
PEERAILTTL KGRRMIRPED SLNIDNFTLD SIDGLAPRLE RGKLGLAAAK KAEVKYTTHD
KLSYLNGEAR AANKLGKNDY AEPQGNSMTN GHKVTNGHNG VTESGPDNMN INHVADLVAS
WKQSSKTALD ELTRHGLMSS LHEAAEELET PYDTLTRLVN AGRQVALVKL GGDLGIFKTL
AESKTPLSSG QLAEYSMAEP LLVARIVRYL VANRLVYEVE PDRYVARKAT YALADPHIES
SLRFFHTVSN PSFQALPDYL RETGYRNQTA GSALQKGLAA EQGLFPWLKE NPDVLGDFQH
LMSIPKEGNG WDVIPLELSV SSTHQGPMLV DIGGNTGQQA RLLVAKHPEL AGRVIVQDRE
ETIKSAPEVK GVQLMAHDFF GPQPVRGARY YYLRAILHNW DEDHAVQILA NIVPAMTADS
LVLIDEVVIP NKGAHVWPAG LDLQMLTLFG GSERTALQWD AILEKAGLKP VVVKKYAPVM
ESCVIFAARK
//
