ID   F0XF96_GROCL            Unreviewed;       848 AA.
AC   F0XF96;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   RecName: Full=Anaphase-promoting complex subunit 4 {ECO:0000256|ARBA:ARBA00016067};
GN   ORFNames=CMQ_1186 {ECO:0000313|EMBL:EFX04258.1};
OS   Grosmannia clavigera (strain kw1407 / UAMH 11150) (Blue stain fungus)
OS   (Graphiocladiella clavigera).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Leptographium.
OX   NCBI_TaxID=655863 {ECO:0000313|Proteomes:UP000007796};
RN   [1] {ECO:0000313|EMBL:EFX04258.1, ECO:0000313|Proteomes:UP000007796}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=kw1407 / UAMH 11150 {ECO:0000313|Proteomes:UP000007796};
RX   PubMed=21262841; DOI=10.1073/pnas.1011289108;
RA   DiGuistini S., Wang Y., Liao N.Y., Taylor G., Tanguay P., Feau N.,
RA   Henrissat B., Chan S.K., Hesse-Orce U., Alamouti S.M., Tsui C.K.M.,
RA   Docking R.T., Levasseur A., Haridas S., Robertson G., Birol I., Holt R.A.,
RA   Marra M.A., Hamelin R.C., Hirst M., Jones S.J.M., Bohlmann J., Breuil C.;
RT   "Genome and transcriptome analyses of the mountain pine beetle-fungal
RT   symbiont Grosmannia clavigera, a lodgepole pine pathogen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:2504-2509(2011).
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DR   EMBL; GL629765; EFX04258.1; -; Genomic_DNA.
DR   RefSeq; XP_014173740.1; XM_014318265.1.
DR   AlphaFoldDB; F0XF96; -.
DR   STRING; 655863.F0XF96; -.
DR   GeneID; 25974036; -.
DR   eggNOG; KOG4640; Eukaryota.
DR   HOGENOM; CLU_011501_0_0_1; -.
DR   InParanoid; F0XF96; -.
DR   OrthoDB; 2722114at2759; -.
DR   Proteomes; UP000007796; Unassembled WGS sequence.
DR   GO; GO:0005680; C:anaphase-promoting complex; IEA:InterPro.
DR   GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR024789; APC4.
DR   InterPro; IPR024977; Apc4-like_WD40_dom.
DR   InterPro; IPR024790; APC4_long_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR13260; ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4; 1.
DR   PANTHER; PTHR13260:SF0; ANAPHASE-PROMOTING COMPLEX SUBUNIT 4; 1.
DR   Pfam; PF12896; ANAPC4; 1.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
PE   4: Predicted;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007796};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          29..117
FT                   /note="Anaphase-promoting complex subunit 4-like WD40"
FT                   /evidence="ECO:0000259|Pfam:PF12894"
FT   DOMAIN          261..460
FT                   /note="Anaphase-promoting complex subunit 4 long"
FT                   /evidence="ECO:0000259|Pfam:PF12896"
FT   REGION          538..596
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        543..566
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   848 AA;  92203 MW;  446DFE9045FA0E48 CRC64;
     MADTSVGVQL FSQGVFSPPA DSADLVAASP AIDLTATAGG GNAVYIWRRG GEVVSKLSER
     NKKVQAVAWK ADGQFLAIAW NDGVVRLVGL ESSKAVHLIR LFEGEPSTVT FISWSKNLVG
     IPETWQAKVL ETLGEEDNDA ILDLPRTLMF LEVEDDLPKL LPLPVSGGLG TSLEVMFPAL
     KPSEGGAIHI MVLGTDDGGI HVCIYDTFVM GTFKVPLPLS SGTHPEAQQP LLRLRGHANH
     PASSTHSLLL SNEDADVNAV YLIPMDFSFI FSSPLNLSLL DYKATTFQKI LRYIKQTQIH
     MQGEWQAARE LPARFLVSIQ EDLQQEPRFK TIDQALRVAA LTGYVPPALK LWLVETISER
     GHKRWDKAVM SGLENLRDLI HENMMPALDR ASLALSRLQG LAEFHSDDDI GFTGDQIGRL
     INMLSCLIVA SHNALALVTS ELELFVMFSA WLRLLIERLA LPGQAEEQAE KEPVMNVTPV
     LDYITNHLLS SPLDLHFGKT ATADWDADWK AIESSSENLM DKLEAELEKV DNIGVEDGLS
     LMPKNGARKR RDDKASAKDA TERQGKRQSA DGLQLNEPAN EEDDGREPET QGGPGVEYMK
     AFPKFEFLTK LLATHADRTL KDIAESGRRH VHFGPVTRLD VGAPVKQAEV AMKAVLKTDL
     EESADVLAFT VITSDESTND FRLFRTAIST SGGISTAVST QVCAVALAGN GSITDIRFLG
     AELILVLWTW TASDRPPLLV AIPVQSPSIR YEKYTEGSTG STEPQTIQLD HGTVREGGGL
     TSSGLCWVAD LSSAGSSGRV VRMEVLGPKT SDDGSGTPAR VQLLYADGAT YRAFALPSVA
     EMFDGRSA
//