ID   F0XNX0_GROCL            Unreviewed;       592 AA.
AC   F0XNX0;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   SubName: Full=Aspartyl aminopeptidase {ECO:0000313|EMBL:EFX00447.1};
GN   ORFNames=CMQ_7449 {ECO:0000313|EMBL:EFX00447.1};
OS   Grosmannia clavigera (strain kw1407 / UAMH 11150) (Blue stain fungus)
OS   (Graphiocladiella clavigera).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Leptographium.
OX   NCBI_TaxID=655863 {ECO:0000313|Proteomes:UP000007796};
RN   [1] {ECO:0000313|EMBL:EFX00447.1, ECO:0000313|Proteomes:UP000007796}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=kw1407 / UAMH 11150 {ECO:0000313|Proteomes:UP000007796};
RX   PubMed=21262841; DOI=10.1073/pnas.1011289108;
RA   DiGuistini S., Wang Y., Liao N.Y., Taylor G., Tanguay P., Feau N.,
RA   Henrissat B., Chan S.K., Hesse-Orce U., Alamouti S.M., Tsui C.K.M.,
RA   Docking R.T., Levasseur A., Haridas S., Robertson G., Birol I., Holt R.A.,
RA   Marra M.A., Hamelin R.C., Hirst M., Jones S.J.M., Bohlmann J., Breuil C.;
RT   "Genome and transcriptome analyses of the mountain pine beetle-fungal
RT   symbiont Grosmannia clavigera, a lodgepole pine pathogen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:2504-2509(2011).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the peptidase M18 family.
CC       {ECO:0000256|ARBA:ARBA00008290}.
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DR   EMBL; GL629801; EFX00447.1; -; Genomic_DNA.
DR   RefSeq; XP_014169929.1; XM_014314454.1.
DR   AlphaFoldDB; F0XNX0; -.
DR   STRING; 655863.F0XNX0; -.
DR   GeneID; 25980994; -.
DR   eggNOG; KOG2596; Eukaryota.
DR   HOGENOM; CLU_019532_3_0_1; -.
DR   InParanoid; F0XNX0; -.
DR   OrthoDB; 1156at2759; -.
DR   Proteomes; UP000007796; Unassembled WGS sequence.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd05658; M18_DAP; 1.
DR   Gene3D; 2.30.250.10; Aminopeptidase i, Domain 2; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR001948; Peptidase_M18.
DR   InterPro; IPR023358; Peptidase_M18_dom2.
DR   PANTHER; PTHR28570; ASPARTYL AMINOPEPTIDASE; 1.
DR   PANTHER; PTHR28570:SF4; VACUOLAR AMINOPEPTIDASE 1; 1.
DR   Pfam; PF02127; Peptidase_M18; 1.
DR   PRINTS; PR00932; AMINO1PTASE.
DR   SUPFAM; SSF101821; Aminopeptidase/glucanase lid domain; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase {ECO:0000256|ARBA:ARBA00022438,
KW   ECO:0000313|EMBL:EFX00447.1}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007796};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   REGION          1..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..53
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   592 AA;  63593 MW;  E327CC74CC1A567C CRC64;
     MAKITSTKLP IHYGLPPSKQ ANEPPQARST ASSGISCHDE VASEQGSDAS QPSQALRSIE
     SQCFAITDMS QRPAAKNTIC ADCAYRMSLD EVKQCRVFFG GEKAVMDSQE CVICSWKTGN
     PAAFTWPYLN FMTENPTIFH AVDYFKQILR VAGFEELTAR EDWSARLRPG GKYYVTRNGS
     TLAAFTIGGA YRPGNGVAIV AGHIDALTAK LKPVSNKPDR AGYVQLGVAP YAGALNETWW
     DRDLGIGGRV VVRDPETGWT TTRLVKLDWP IAKIPTLAPH FGVSMTGQGN KETQLVPVIG
     LDSGSKTGSM AEQARTVEPA LGPAGSFIAS QPPKLVKLIA AELGVKSYAS IVNWELELFD
     TQPATVFGLD KEMISAGRID DKICSWAALV ALLRARDNDS SGVVRLVALF DDEEIGSLLR
     QGAKSNFLPL TVERIVEALS PPIVGSFGPG VIGRTYASSF LISSDVTHAI HPNFVANYLD
     DHAPKLNVGV AITHDSNGHM TTDSVSTAQL QRVAELSGST LQRFMIRNDS RSGGTIGPSL
     SSAMGVKSAD AGIPQLSMHS IRASTGALDP GLGVRFFQGF LENWETVDAE WQ
//