ID F0XR09_GROCL Unreviewed; 356 AA.
AC F0XR09;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=2-dehydropantoate 2-reductase {ECO:0000313|EMBL:EFW99794.1};
GN ORFNames=CMQ_112 {ECO:0000313|EMBL:EFW99794.1};
OS Grosmannia clavigera (strain kw1407 / UAMH 11150) (Blue stain fungus)
OS (Graphiocladiella clavigera).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Leptographium.
OX NCBI_TaxID=655863 {ECO:0000313|Proteomes:UP000007796};
RN [1] {ECO:0000313|EMBL:EFW99794.1, ECO:0000313|Proteomes:UP000007796}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=kw1407 / UAMH 11150 {ECO:0000313|Proteomes:UP000007796};
RX PubMed=21262841; DOI=10.1073/pnas.1011289108;
RA DiGuistini S., Wang Y., Liao N.Y., Taylor G., Tanguay P., Feau N.,
RA Henrissat B., Chan S.K., Hesse-Orce U., Alamouti S.M., Tsui C.K.M.,
RA Docking R.T., Levasseur A., Haridas S., Robertson G., Birol I., Holt R.A.,
RA Marra M.A., Hamelin R.C., Hirst M., Jones S.J.M., Bohlmann J., Breuil C.;
RT "Genome and transcriptome analyses of the mountain pine beetle-fungal
RT symbiont Grosmannia clavigera, a lodgepole pine pathogen.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:2504-2509(2011).
CC -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC {ECO:0000256|ARBA:ARBA00007870}.
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DR EMBL; GL629807; EFW99794.1; -; Genomic_DNA.
DR RefSeq; XP_014169209.1; XM_014313734.1.
DR AlphaFoldDB; F0XR09; -.
DR STRING; 655863.F0XR09; -.
DR GeneID; 25973963; -.
DR eggNOG; ENOG502QPT5; Eukaryota.
DR HOGENOM; CLU_031468_9_0_1; -.
DR InParanoid; F0XR09; -.
DR OrthoDB; 1354873at2759; -.
DR Proteomes; UP000007796; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR013332; KPR_N.
DR PANTHER; PTHR43765; 2-DEHYDROPANTOATE 2-REDUCTASE-RELATED; 1.
DR PANTHER; PTHR43765:SF2; 2-DEHYDROPANTOATE 2-REDUCTASE-RELATED; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007796}.
FT DOMAIN 50..150
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 188..314
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 356 AA; 39377 MW; 421D3F8D081FE1A2 CRC64;
MHQLSQSGQR EHGGAETAPL VDFDVEMWSE EPPPWPREAR EITPTVGGIP SKIQNLIIAT
KAQNSLAQAD WLRRYLGPES TVAFAQNGMN KLWPPHGSAY NRARYCCQRQ GQQYLQNPLW
LVCIVMHGVV SLGPFESIHA SPAGVVVGPV GTDHSSQDVS SSYLVKQLLE APQLNTRYAQ
RPELWVLQLE KLVVNSIINP LTTILRCKNG DLFSGSEDGD TVSRIMDRLI EEASGVFQCL
VQYDANSRGI LEDVSADSSH LLIERLSVPN LGRMLYDVGE VVKDNTSSML QDARMGRTTE
VREFNGWFVD TADYLLGLDD VSAETVDVTY HTALIELVES GTSLTRDQLG EHLSIG
//
