ID F0XXP2_AURAN Unreviewed; 1300 AA.
AC F0XXP2;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Major facilitator superfamily (MFS) profile domain-containing protein {ECO:0000259|PROSITE:PS50850};
GN ORFNames=AURANDRAFT_61268 {ECO:0000313|EMBL:EGB12316.1};
OS Aureococcus anophagefferens (Harmful bloom alga).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Pelagophyceae; Pelagomonadales;
OC Aureococcus.
OX NCBI_TaxID=44056 {ECO:0000313|Proteomes:UP000002729};
RN [1] {ECO:0000313|EMBL:EGB12316.1, ECO:0000313|Proteomes:UP000002729}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP 1984 {ECO:0000313|Proteomes:UP000002729};
RX PubMed=21368207; DOI=10.1073/pnas.1016106108;
RA Gobler C.J., Berry D.L., Dyhrman S.T., Wilhelm S.W., Salamov A.,
RA Lobanov A.V., Zhang Y., Collier J.L., Wurch L.L., Kustka A.B., Dill B.D.,
RA Shah M., VerBerkmoes N.C., Kuo A., Terry A., Pangilinan J., Lindquist E.A.,
RA Lucas S., Paulsen I.T., Hattenrath-Lehmann T.K., Talmage S.C., Walker E.A.,
RA Koch F., Burson A.M., Marcoval M.A., Tang Y.Z., Lecleir G.R., Coyne K.J.,
RA Berg G.M., Bertrand E.M., Saito M.A., Gladyshev V.N., Grigoriev I.V.;
RT "Niche of harmful alga Aureococcus anophagefferens revealed through
RT ecogenomics.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:4352-4357(2011).
CC -!- PATHWAY: Amino-acid biosynthesis; ergothioneine biosynthesis.
CC {ECO:0000256|ARBA:ARBA00037882}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GL833121; EGB12316.1; -; Genomic_DNA.
DR RefSeq; XP_009033368.1; XM_009035120.1.
DR EnsemblProtists; EGB12316; EGB12316; AURANDRAFT_61268.
DR GeneID; 20223394; -.
DR KEGG; aaf:AURANDRAFT_61268; -.
DR eggNOG; KOG0255; Eukaryota.
DR InParanoid; F0XXP2; -.
DR OrthoDB; 1416at2759; -.
DR Proteomes; UP000002729; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR Gene3D; 3.90.1580.10; paralog of FGE (formylglycine-generating enzyme); 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR024775; DinB-like.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR027577; OvoA_Nterm.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR InterPro; IPR005532; SUMF_dom.
DR InterPro; IPR042095; SUMF_sf.
DR NCBIfam; TIGR04344; ovoA_Nterm; 1.
DR PANTHER; PTHR23150:SF26; METHYLTRANSFERASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR23150; SULFATASE MODIFYING FACTOR 1, 2; 1.
DR Pfam; PF12867; DinB_2; 1.
DR Pfam; PF03781; FGE-sulfatase; 1.
DR Pfam; PF13489; Methyltransf_23; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 920..939
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 951..971
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 977..998
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1010..1030
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1050..1068
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1101..1127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1139..1157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1164..1186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1198..1222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1261..1280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 870..1285
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 843..872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1300 AA; 136490 MW; 8DAA50D7EDA91F5D CRC64;
MLARGPSCFA FNARRGALGL GQLGSQGGRA LPVLARRFSE KAAAPTSLAP GQCPDYWTGL
EPEACPGFEP ATATLSSLKP PDLRLRGPAL RAALEAYFEN GWALTEVLFS GLKDEDVFVR
PPAHGLRHAM IFYYGHPAAL AINKLRAARR VAGAITEGVV PRWEVLFETG VDEMSWDDLD
TPQTAWPTVG AVTDYRRRCR DVYLDVVRNH PALDAPLAAG APTDSNAVVW SLGMICEHER
IHLETSTTLI RELPLECVRR PDHWPLDHAS AWAEGEDAPV ELRRVAAGTV TLGKPRTHGS
YSWDNEYGSR SIDVPAFECA RTPVTNGQFL EFVRAGGYAD PAHWTEEGWA WRSFRNTKWP
HFWVSKGPQG LHDYALRLPF AETSALPRGL PVEINKHEAA AYTAWLASTL GCDLRLPSEA
EYARLREVNA DAEGAGPSIR DAAVDEARDA AVALDAPELR AKDVNLSLAY GSPSAVDAGA
QARLPFPSLA GNCWEYCEDW FAALPGFKAS PLYEDFSTPC FDGQHALILG GSFVATGNEA
SLFSRFHFRP HFHNMIGFRV VRGTTNPELS SHDAPPPWAA GWVPPAYVRE KESEEGGHKY
ESRAQLAAYL DLHHGGAGAL DGPAADLASY DLRDALDFPR RCADVLVAAT GAAAGARALD
VGCAVGGSAF AMAESGAFGD VVGVDFAQSF VDAAAELNAA GELRYERSGE AGGRGARATA
AVASSGALSF RRADACDLPA DLGGFDAVLA ANLLCRLPDP AAFLDRLGAG LVNPGGAVYI
VSPFSWMEEY TPEASWLSPE ALEAKMKANG FDLERETPEA LVIRDHARKF QFITAPSLRQ
SEMVVRRAPP PTDDAGEGLL DGASRRSGCS TKDVDDGGPL PWGCLAALGL ANAAEAVEVL
CTSYLLTGIP AAASRAAVSS GVYCGMLVGG VGGGVLADGA RWGGQLPRTR VLVGAMALAC
LGGLGASTAR SAADMCFWRV LAGAGVGAAT PPLFALAAEV SDGPKRGRGI AFVASFWMVG
GVFAAALAMG LLPDDLRVDW SASAAAPWRV YAACSALPSA ASGVVFLARG AGERKVLDAA
ARAPPADGAR ASSERDERRR VFLFLAVAFW GLYFGYYGLA TWITVIVDEA HIGNTYVVAL
YYAAANLPGN VAAYALIDAV GRQRLLAGAM GTATLACVLL AVSLGGEADG LAAWEKTAAV
AAALLVNAAT TAGFSALDAL AAESFDAARR ATHVGLLCAI GRVASISAQL VNSTLAESPA
LLVAVTSALM CLGALATFGI REPADVVGGV AADGTSAGLV
//
