ID F0Y1J1_AURAN Unreviewed; 825 AA.
AC F0Y1J1;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Cytochrome b5 heme-binding domain-containing protein {ECO:0000259|PROSITE:PS50255};
GN ORFNames=AURANDRAFT_62349 {ECO:0000313|EMBL:EGB10834.1};
OS Aureococcus anophagefferens (Harmful bloom alga).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Pelagophyceae; Pelagomonadales;
OC Aureococcus.
OX NCBI_TaxID=44056 {ECO:0000313|Proteomes:UP000002729};
RN [1] {ECO:0000313|EMBL:EGB10834.1, ECO:0000313|Proteomes:UP000002729}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP 1984 {ECO:0000313|Proteomes:UP000002729};
RX PubMed=21368207; DOI=10.1073/pnas.1016106108;
RA Gobler C.J., Berry D.L., Dyhrman S.T., Wilhelm S.W., Salamov A.,
RA Lobanov A.V., Zhang Y., Collier J.L., Wurch L.L., Kustka A.B., Dill B.D.,
RA Shah M., VerBerkmoes N.C., Kuo A., Terry A., Pangilinan J., Lindquist E.A.,
RA Lucas S., Paulsen I.T., Hattenrath-Lehmann T.K., Talmage S.C., Walker E.A.,
RA Koch F., Burson A.M., Marcoval M.A., Tang Y.Z., Lecleir G.R., Coyne K.J.,
RA Berg G.M., Bertrand E.M., Saito M.A., Gladyshev V.N., Grigoriev I.V.;
RT "Niche of harmful alga Aureococcus anophagefferens revealed through
RT ecogenomics.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:4352-4357(2011).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GL833123; EGB10834.1; -; Genomic_DNA.
DR RefSeq; XP_009034416.1; XM_009036168.1.
DR AlphaFoldDB; F0Y1J1; -.
DR EnsemblProtists; EGB10834; EGB10834; AURANDRAFT_62349.
DR GeneID; 20223849; -.
DR KEGG; aaf:AURANDRAFT_62349; -.
DR InParanoid; F0Y1J1; -.
DR OMA; NARTFDW; -.
DR OrthoDB; 2712490at2759; -.
DR Proteomes; UP000002729; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0080132; F:fatty acid alpha-hydroxylase activity; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR014430; Scs7.
DR PANTHER; PTHR12863:SF1; FATTY ACID 2-HYDROXYLASE; 1.
DR PANTHER; PTHR12863; FATTY ACID HYDROXYLASE; 1.
DR Pfam; PF00173; Cyt-b5; 1.
DR Pfam; PF13450; NAD_binding_8; 1.
DR SMART; SM01117; Cyt-b5; 1.
DR SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS50255; CYTOCHROME_B5_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 136..210
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000259|PROSITE:PS50255"
FT REGION 91..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 825 AA; 88979 MW; 16C6EC6E6B3733E6 CRC64;
MMVAKRAGML AATSQRSLRA ARASSSAARA APRRRAAAAA AGAGAGAALA AAAYRADAWA
PLLDAVASTR ALCDGAVRSF DDMDRGEKAK KSAALKTKQE HPTHSALDGG KVTVDLDEDD
VAELEVMALA DVEACRADVS RDGGGGQLLC TYEGIVYDVT QFAESHPGGK ELLLTATGLD
LKHFFDNYTV HGHSDKAARW LAPLAVGKLS PEDAALASAR STPEAHVDRR MARLGAARRR
LLAVAAALPL AIGVRECVRA IGRYLSATVA KWVAARLPIA VAGFSPCFSP GSEPLPATED
GSARGVVAVV GGGIAGCSAA WMLARDGFEV HLYEARPATS GNARTFDWVD DTWTQSCVSN
TGKDDTVKSC VSVTAWPPLL YKNYTALLAH LNVETVAMPL SWFLNSKVPG YEGTLWGADP
RCDVANGVNT LRSVFANDFR KYAAVELFAR RCTEFFTLAW APWKRHDTMS MYTNHTGLGM
LNPLNVVPLY SLFKGVGGSD EWWDIIFTPY YTASFLVDEL RPFPAVFGPI IEAQIPLNPT
PENSWHGASA KTDADCKLTT CVTWKDAGTG IRAVFAKLVE DVDVKVDTRV LEVRVMPDGT
KRVVDEHDGV LVADRVIFAC PCNAAMTMLK KPDKRLEETV MAAPVYADDH HPATGHMHAV
MHSDPSVIDA QYRSDFLDRG SNYVEVTKLK DGSINIENQY NFGIQTPGPG VYDLPLDKKP
VMLISHALGE GKKIDETLVR GGGNHSRAHP LYSGWNVMAQ LSLRLCQGLD GLYYCSNWTT
PGNCHDMSLL SGFLCATAIG AEYPFPDDAE ARKDLHRLND LMGVF
//
